Reactome | IVL [cytosol]

IVL [cytosol]

Stable Identifier

R-HSA-6810837

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Involucrin, INVO_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Developmental Cell Lineages (Homo sapiens)
  - Differentiation of keratinocytes in interfollicular epidermis in mammalian skin (Homo sapiens)
    - Keratinocyte of granulosum layer differentiates into corneocyte of corneum layer in interfollicular epidermis (Homo sapiens)
      - keratinocyte of granulosum layer of epidermis (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
    - Keratinocyte of spinosum layer differentiates into keratinocyte of granulosum layer in interfollicular epidermis (Homo sapiens)
      - keratinocyte of granulosum layer of epidermis (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
- Keratinization (Homo sapiens)
  - Formation of the cornified envelope (Homo sapiens)
    - CASP14 cleaves filaggrin (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
    - CDSN binds the cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
    - Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)
      - EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
      - IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
    - Lamellar bodies bind the early cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
    - Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
    - Plasma membrane resorption (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
    - Reinforcement of the Cornified Envelope (Homo sapiens)
      - EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)
    - TGM1 and involucrin bind the plasma membrane (Homo sapiens)
      - IVL [cytosol] (Homo sapiens)
      - IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07476 IVL

Gene Names

IVL

Chain

chain:1-585

Reference Genes

BioGPS Gene:3713 IVL

COSMIC (genes):IVL IVL

CTD Gene:3713 IVL

dbSNP Gene:3713 IVL

ENSEMBL:ENSG00000163207 IVL

ENSEMBL_homo_sapiens_GENE:ENSG00000163207.7 IVL

HGNC:6187 IVL

KEGG Gene (Homo sapiens):3713 IVL

Monarch:3713 IVL

NCBI Gene:3713 IVL

OMIM:147360 IVL

UCSC:P07476 IVL

Reference Transcript

RefSeq:NM_005547.2 IVL

Other Identifiers

11731653_a_at

16671094

214599_PM_at

214599_at

2359467

2359471

2359472

2359473

2359474

36355_at

3713

7905533

A_14_P120925

A_23_P353524

GE724623

GO:0001533

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0010224

GO:0016604

GO:0018149

GO:0018153

GO:0030154

GO:0030216

GO:0031424

GO:0036211

GO:0043226

GO:0048856

GO:0070062

HMNXSV003050676

Hs.157091.0.S2_3p_at

ILMN_1775883

M13903_at

PH_hs_0029259

TC01001244.hg

Participates

as a protein marker of

keratinocyte of granulosum layer of epidermis (Homo sapiens)

as an input of

TGM1 and involucrin bind the plasma membrane (Homo sapiens)

as a component of

IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)

Other forms of this molecule

IVL [cornified envelope]

Inferred To

Ghost homologue of IVL [cytosol] (Bos taurus)

Ghost homologue of IVL [cytosol] (Canis familiaris)

Ghost homologue of IVL [cytosol] (Mus musculus)

Ghost homologue of IVL [cytosol] (Rattus norvegicus)

Ghost homologue of IVL [cytosol] (Sus scrofa)

Ghost homologue of IVL [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005538.2

OpenTargets

ENSG00000163207

HPA

ENSG00000163207-IVL

GeneCards

P07476

Ensembl

ENSP00000357753, ENSG00000163207, ENST00000368764

PRO

P07476

Pharos - Targets

P07476

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NU19 TB22B			0.527	2
UniProt:Q96IK5 GMCL1			0.527	2
UniProt:Q9H845 ACAD9	1	ACAD9 [mitochondrial inner membrane] (R-HSA-5689049)	0.527	2
UniProt:O43309 ZSC12			0.527	2
UniProt:Q96BH1 RNF25	1	RNF25 [cytosol] (R-HSA-975976)	0.527	2
UniProt:Q9NP50 SHCAF			0.527	2
UniProt:Q9BX46 RBM24			0.527	2
UniProt:P02794 FTH1	5	FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [cytosol] (R-HSA-434212) FTH1 [endocytic vesicle lumen] (R-HSA-2299670) FTH1 [extracellular region] (R-HSA-2187212)	0.527	2
UniProt:Q8N878 FRMD1			0.527	2
UniProt:Q14943 KIR3DS1	1	KIR3DS1 [plasma membrane] (R-HSA-2159806)	0.527	2
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.527	2
UniProt:Q9HAW8 UGT1A10	1	UGT1A10 [endoplasmic reticulum membrane] (R-HSA-8933307)	0.527	2
UniProt:P01160 NPPA	5	NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2
UniProt:Q9Y324 FCF1	1	FCF1 [nucleoplasm] (R-HSA-6790672)	0.527	2
UniProt:Q9NWU2 GID8	1	GID8 [cytosol] (R-HSA-9861665)	0.508	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2