TGM1 and involucrin bind the plasma membrane

Stable Identifier
Reaction [binding]
Homo sapiens
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Transglutaminase-1 (TGM1) and involucrin (IVL) are expressed shortly after envoplakin and periplakin. TGM1 associates with the plasma membrane via C14-16 fatty-acid adducts on its C-terminus (Steinert et al. 1996). IVL deposition precedes that of most other cornified envelope proteins (Nemes & Steinert 1999). It can bind the plasma membrane in a calcium and phosphatidyl-serine dependent manner, where it becomes a substrate for membrane-bound TGM1 and TGM5 (Nemes et al. 1999, Candi et al. 2001).

Literature References
PubMed ID Title Journal Year
10231017 Bricks and mortar of the epidermal barrier

Steinert, PM, Nemes, Z

Exp. Mol. Med. 1999
8824274 The transglutaminase 1 enzyme is variably acylated by myristate and palmitate during differentiation in epidermal keratinocytes

Kim, SY, Steinert, PM, Chung, SI, Marekov, LN

J. Biol. Chem. 1996
10196183 Involucrin cross-linking by transglutaminase 1. Binding to membranes directs residue specificity

Steinert, PM, Nemes, Z, Marekov, LN

J. Biol. Chem. 1999
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