Reactome | STX6 [trans-Golgi network membrane]

STX6 [trans-Golgi network membrane]

Stable Identifier

R-HSA-6811007

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

Synonyms

Syntaxin-6

Locations in the PathwayBrowser for interactor UniProt:O75379 VAMP4

Expand all

External Reference Information

External Reference

UniProt:O43752 STX6

Gene Names

STX6

Chain

initiator methionine:, chain:2-255

Reference Genes

BioGPS Gene:10228 STX6

COSMIC (genes):STX6 STX6

CTD Gene:10228 STX6

dbSNP Gene:10228 STX6

ENSEMBL:ENSG00000135823 STX6

ENSEMBL_homo_sapiens_GENE:ENSG00000135823.14 STX6

HGNC:11441 STX6

KEGG Gene (Homo sapiens):10228 STX6

Monarch:10228 STX6

NCBI Gene:10228 STX6

OMIM:603944 STX6

UCSC:O43752 STX6

Reference Transcript

Other Identifiers

10228

11720382_at

11720383_a_at

11720384_at

1552618_PM_at

1552618_at

16696924

212799_PM_at

212799_at

212800_PM_at

212800_at

214441_PM_at

214441_at

2446598

2446599

2446600

2446601

2446602

2446603

2446604

2446605

2446606

2446607

2446608

2446610

2446612

2446614

2446619

2446620

2446624

2446625

2446634

2446635

33079_at

41663_at

7922669

82326_at

91161_at

A_23_P97725

A_24_P639505

GE54320

GE79791

GO:0000139

GO:0000149

GO:0005484

GO:0005515

GO:0005634

GO:0005654

GO:0005768

GO:0005769

GO:0005794

GO:0005802

GO:0005829

GO:0005886

GO:0006886

GO:0006906

GO:0007032

GO:0008021

GO:0012505

GO:0015031

GO:0016020

GO:0016189

GO:0016192

GO:0019905

GO:0030136

GO:0030672

GO:0031090

GO:0031201

GO:0031410

GO:0032456

GO:0032588

GO:0032880

GO:0042147

GO:0043226

GO:0045335

GO:0048193

GO:0048278

GO:0048471

GO:0055037

GO:0055038

GO:0060090

GO:0061024

HMNXSV003034773

Hs.12311.0.S1_3p_at

Hs.12311.0.S2_3p_at

Hs.157144.0.S1_3p_s_at

Hs2.157144.1.A2_3p_at

ILMN_1777915

ILMN_2157951

PH_hs_0009501

PH_hs_0036128

TC01003596.hg

Participates

as an output of

NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN (Homo sapiens)

as a component of

Other forms of this molecule

STX6 [Golgi membrane]

Inferred To

STX6 [trans-Golgi network membrane] (Bos taurus)

STX6 [trans-Golgi network membrane] (Gallus gallus)

Stx6 [trans-Golgi network membrane] (Mus musculus)

Stx6 [trans-Golgi network membrane] (Rattus norvegicus)

Syx6 [trans-Golgi network membrane] (Drosophila melanogaster)

tlg1 [trans-Golgi network membrane] (Schizosaccharomyces pombe)

syn10 [trans-Golgi network membrane] (Dictyostelium discoideum)

Ghost homologue of STX6 [trans-Golgi network membrane] (Caenorhabditis elegans)

Ghost homologue of STX6 [trans-Golgi network membrane] (Canis familiaris)

Ghost homologue of STX6 [trans-Golgi network membrane] (Sus scrofa)

Ghost homologue of STX6 [trans-Golgi network membrane] (Xenopus tropicalis)

TLG1 [trans-Golgi network membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_016855496.1, NP_005810.1, NP_001273139.1

OpenTargets

ENSG00000135823

HPA

ENSG00000135823-STX6

GeneCards

O43752

Ensembl

ENSP00000440188, ENST00000542060, ENSP00000258301, ENSG00000135823, ENST00000258301

PRO

O43752

Pharos - Targets

O43752

PDB

4J2C, 2NPS

Interactors (54)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12846 STX4	4	STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [plasma membrane] (R-HSA-181519) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.871	9
UniProt:Q86Y82 STX12			0.824	10
UniProt:Q9H115 NAPB	1	NAPB [cytosol] (R-HSA-5688553)	0.743	5
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.725	7
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.688	4
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.669	4
UniProt:Q9P0T7 TMEM9			0.666	4
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.666	5
UniProt:Q9UID3-1 VPS51			0.66	8
UniProt:P54920 NAPA	1	NAPA [cytosol] (R-HSA-264469)	0.643	4
UniProt:P46459 NSF	1	NSF [cytosol] (R-HSA-264471)	0.643	3
UniProt:Q9BV40 VAMP8	11	VAMP8 [recycling endosome membrane] (R-HSA-8863891) VAMP8 [phagocytic vesicle membrane] (R-HSA-8863896) VAMP8 [tertiary granule membrane] (R-HSA-6801024) VAMP8 [plasma membrane] (R-HSA-376365) VAMP8 [azurophil granule membrane] (R-HSA-6799703) VAMP8 [specific granule membrane] (R-HSA-6799707) VAMP8 [lysosomal membrane] (R-HSA-432710) VAMP8 [Golgi membrane] (R-HSA-266201) VAMP8 [cytoplasmic vesicle membrane] (R-HSA-376373) VAMP8 [secretory granule membrane] (R-HSA-376368) VAMP8 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869137)	0.643	4
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
IntAct:EBI-23653849 CCSB ORF ID			0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:Q9H400 LIME1			0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q9NY72 SCN3B	1	SCN3B [plasma membrane] (R-HSA-197921)	0.556	3
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.556	3
UniProt:Q49AM1 MTEF2			0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:Q9NUH8 TM14B			0.556	3
UniProt:P32856-2 STX2			0.556	3
UniProt:Q6UW68 TM205			0.556	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q8IUR7-6 ARMC8			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:P27105 STOM	4	STOM [tertiary granule membrane] (R-HSA-6800960) STOM [plasma membrane] (R-HSA-6806258) STOM [azurophil granule membrane] (R-HSA-6800997) STOM [specific granule membrane] (R-HSA-6799569)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:O60637 TSN3			0.527	2
UniProt:O95183 VAMP5			0.527	3
UniProt:Q96AJ9 VTI1A	2	VTI1A [trans-Golgi network membrane] (R-HSA-6813927) VTI1A [Golgi membrane] (R-HSA-6811035)	0.527	3
UniProt:O94766 B3GAT3	2	B3GAT3 R277Q [Golgi membrane] (R-HSA-3621732) B3GAT3 [Golgi membrane] (R-HSA-1889987)	0.527	2
UniProt:Q96G30 MRAP2			0.527	2
UniProt:Q9Y2V7 COG6	2	COG6 [Golgi membrane] (R-HSA-2980958) COG6 [trans-Golgi network membrane] (R-HSA-6813872)	0.527	2
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.527	3
UniProt:O75558 STX11			0.527	2
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.527	2
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.527	2
UniProt:Q86VY9 T200A			0.527	3
UniProt:Q9NRW7 VPS45	2	VPS45 [Golgi membrane] (R-HSA-6811025) VPS45 [endosome membrane] (R-HSA-1011607)	0.527	2
UniProt:Q99747 NAPG	1	NAPG [cytosol] (R-HSA-5688555)	0.527	3
UniProt:Q6P995 F171B			0.527	2
UniProt:Q8NHX9 TPCN2	1	TPCN2 [lysosomal membrane] (R-HSA-2685518)	0.527	2
UniProt:Q9UNK0 STX8			0.527	4
UniProt:Q9P2W9 STX18	1	STX18 [endoplasmic reticulum membrane] (R-HSA-2029079)	0.527	3
UniProt:P0DTD8 NS7B			0.527	2
UniProt:Q8WVM8 SCFD1	1	SCFD1 [cytosol] (R-HSA-5688147)	0.527	2
UniProt:P51809 VAMP7	6	VAMP7 [late endosome membrane] (R-HSA-2193120) VAMP7 [lysosomal membrane] (R-HSA-376342) VAMP7 [plasma membrane] (R-HSA-376361) VAMP7 [Golgi membrane] (R-HSA-266197) VAMP7 [cytoplasmic vesicle membrane] (R-HSA-376336) VAMP7 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869135)	0.527	2
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.483	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.463	3

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