Reactome | Active ARF recruits coatomer to the Golgi

Active ARF recruits coatomer to the Golgi

Stable Identifier

R-HSA-6811412

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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Active ARF recruits coatomer to the Golgi

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Activation of ARF is tightly correlated to recruitment of the COPI coat (Donaldson et al, 1991; Serafini et al, 1991; Donaldson et el, 1992; Palmer et al, 1993; reveiwed in Szul and Sztul, 2011). Studies in yeast and in mammalian cells support a direct interaction between the GTPase and components of the COPI coat (Zhao et al, 1997; Zhao et al, 1999; Zhao et al, 2006; Eugster et al, 2000; Sun et al, 2007; Yu et al, 2012; Harter and Wieland, 1998; Bethune et al, 2006; reviewed in Popoff et al, 2011). The COPI coat consists of 7 subunits arranged in 2 subcomplexes. The inner coat is made up of a tetrameric complex consisting of the beta, gamma, zeta and delta COPI subunits, while the outer coat is a trimer consisting of the alpha, beta prime and epsilon subunits (Eugster et al, 2000; Waters et al, 1991). Both of the zeta and gamma subunits have 2 isoforms with different subcellular locations, suggesting that different COPI coats may mediate different steps of the secretory pathway (Moelleken et al, 2007). Unlike the case for COPII or clathrin coats, all components of the COPI coat are recruited simultaneously as a preformed heptameric complex (Hara-Kuge et al, 1994).

Literature References

PubMed ID	Title	Journal	Year
17360540	Differential localization of coatomer complex isoforms within the Golgi apparatus Russell, RB, Moelleken, J, Meissner, I, Söllner, T, Betts, MJ, Brugger, B, Wieland, FT, Malsam, J, Hellwig, A, Movafeghi, A, Reckmann, I	Proc. Natl. Acad. Sci. U.S.A.	2007
10318838	GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23 Zhao, L, Wieland, FT, Helms, JB, Brunner, J	J. Biol. Chem.	1999
1680566	ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein Serafini, T, Brunner, M, Orci, L, Amherdt, M, Rothman, JE, Kahn, RA	Cell	1991
22304919	A structure-based mechanism for Arf1-dependent recruitment of coatomer to membranes Yu, X, Goldberg, J, Breitman, M	Cell	2012
16926190	GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic Presley, JF, Melançon, P, Claude, A, Zhao, X, Chun, J, Shields, DJ	J. Cell. Sci.	2006
1631136	ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes Donaldson, JG, Klausner, RD, Kahn, RA, Cassel, D	Proc. Natl. Acad. Sci. U.S.A.	1992
22013193	COPII and COPI traffic at the ER-Golgi interface Sztul, E, Szul, T	Physiology (Bethesda)	2011
21844168	COPI budding within the Golgi stack Popoff, V, Wieland, F, Adolf, F, Brugger, B	Cold Spring Harb Perspect Biol	2011
1898986	'Coatomer': a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles Serafini, T, Waters, MG, Rothman, JE	Nature	1991
1957170	Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein Lippincott-Schwartz, J, Donaldson, JG, Klausner, RD, Kahn, RA	Science	1991
9751720	A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer Harter, C, Wieland, FT	Proc. Natl. Acad. Sci. U.S.A.	1998
8132710	En bloc incorporation of coatomer subunits during the assembly of COP-coated vesicles Ravazzola, M, Orci, L, Hara-Kuge, S, Amherdt, M, Wieland, FT, Rothman, JE, Kuge, O	J. Cell Biol.	1994
16940185	Coatomer, the coat protein of COPI transport vesicles, discriminates endoplasmic reticulum residents from p24 proteins Wieland, F, Brugger, B, Hoffmann, J, Reckmann, I, Kol, M, Béthune, J	Mol. Cell. Biol.	2006
9114004	Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta Brugger, B, Zhao, L, Harter, C, Wieland, FT, Graf, R, Helms, JB, Brunner, J, Martoglio, B	Proc. Natl. Acad. Sci. U.S.A.	1997
8505331	Binding of coatomer to Golgi membranes requires ADP-ribosylation factor Orci, L, Beckers, CJ, Palmer, DJ, Helms, JB, Rothman, JE	J. Biol. Chem.	1993
17451557	Multiple and stepwise interactions between coatomer and ADP-ribosylation factor-1 (Arf1)-GTP Wieland, F, Brugger, B, Zhao, L, Fröhlich, K, Anderl, F, Béthune, J, Hanke, S, Sun, Z	Traffic	2007
10921873	COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP Frigerio, G, Eugster, A, Dale, M, Duden, R	EMBO J.	2000