Reactome | RAB:GTP recruits GBF1 to the Golgi membrane

RAB:GTP recruits GBF1 to the Golgi membrane

Stable Identifier

R-HSA-6811415

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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RAB:GTP recruits GBF1 to the Golgi membrane

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In its GTP-bound active state, RAB1 recruits the ARF GEF GBF1 to the Golgi (Monetta et al, 2007). GBF is the only ARF activator required for the formation of COPI coats, and therefore it has roles in the anterograde ERGIC-to-cis-Golgi as well as in COPI-mediated retrograd transport within the Golgi and back to the ERGIC and ER (Kawamoto et al, 2002; Szul et al, 2005; Zhao et al, 2006; Szul et al, 2007; reviewed in Szul and Sztul, 2011). GBR1 activates ARF1, 2, 3 and 5 which play overlapping roles in the secretory pathway (Volpicelli-Daley et al, 2005; Chun et al, 2008; reviewed in D'Souza-Schorey and Chavrier, 2006).

Literature References

PubMed ID	Title	Journal	Year
12047556	GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat Yoshida, Y, Tamaki, H, Kawamoto, K, Yamashina, S, Nakayama, K, Torii, S, Shinotsuka, C	Traffic	2002
18524849	Characterization of class I and II ADP-ribosylation factors (Arfs) in live cells: GDP-bound class II Arfs associate with the ER-Golgi intermediate compartment independently of GBF1 Presley, JF, Melançon, P, Chun, J, Dejgaard, SY, Shapovalova, Z	Mol. Biol. Cell	2008
22013193	COPII and COPI traffic at the ER-Golgi interface Sztul, E, Szul, T	Physiology (Bethesda)	2011
17429068	Rab1b interacts with GBF1 and modulates both ARF1 dynamics and COPI association Slavin, I, Monetta, P, Romero, N, Alvarez, C	Mol. Biol. Cell	2007
16030262	Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic Volpicelli-Daley, LA, Zhang, CJ, Li, Y, Kahn, RA	Mol. Biol. Cell	2005
16926190	GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic Presley, JF, Melançon, P, Claude, A, Zhao, X, Chun, J, Shields, DJ	J. Cell. Sci.	2006
15813748	Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1 Shestopal, S, Sztul, E, Szul, T, Alvarez, C, Brandon, E, Garcia-Mata, R	Traffic	2005
16633337	ARF proteins: roles in membrane traffic and beyond Chavrier, P, D'Souza-Schorey, C	Nat. Rev. Mol. Cell Biol.	2006
17956946	Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking Grabski, R, Shestopal, S, Morohashi, Y, Lyons, S, Sztul, E, Szul, T, Lowe, M	J. Cell. Sci.	2007