Reactome | The COG tethering complex interacts with numerous SNAREs at the Golgi membrane

The COG tethering complex interacts with numerous SNAREs at the Golgi membrane

Stable Identifier

R-HSA-6811433

Type

Reaction [binding]

Species

Homo sapiens

Compartment

Golgi membrane

ReviewStatus

5/5

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The COG tethering complex interacts with numerous SNAREs at the Golgi membrane

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Octameric COG (Conserved Oligomeric Golgi) is a Golgi localized tethering complex that aids in the capture of vesicles during intra-Golgi traffic as well as the capture of retrograde vesicles from the endosome at the trans-Golgi network (Zolov and Lupashin, 2005; reviewed in Willet et al, 2013a). Consistent with this, the COG complex interacts with many of the proteins involved in vesicle targeting, including SNAREs, coat proteins and RABs, among others. At the Golgi, COG has been shown to interact with Golgi SNAREs STX6, STX6, STX16, GOSR1, GOSR2, BET1L, SNAP29, VPS45 and VTI1A, but not other Golgi SNAREs and not ERGIC-resident SNAREs (Suvorora et al, 2002; Laufman et al, 2009; Laufman et al, 2011; Laufman et al, 2013; Shestakova et al, 2007; Willet et al, 2013b). The function of each of these COG-Golgi SNARE interactions has not yet been characterized in full detail (reviewed in Willet et al, 2013a).

Literature References

PubMed ID	Title	Journal	Year
21807881	The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport Hong, W, Lev, S, Laufman, O	J. Cell Biol.	2011
19536132	Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing Hong, W, Lev, S, Kedan, A, Laufman, O	EMBO J.	2009
23378023	The COG complex interacts with multiple Golgi SNAREs and enhances fusogenic assembly of SNARE complexes Hong, W, Lev, S, Laufman, O	J. Cell. Sci.	2013
15728195	Cog3p depletion blocks vesicle-mediated Golgi retrograde trafficking in HeLa cells Lupashin, VV, Zolov, SN	J. Cell Biol.	2005
12011112	The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins Lupashin, VV, Suvorova, ES, Duden, R	J. Cell Biol.	2002
23462996	COG complexes form spatial landmarks for distinct SNARE complexes Kudlyk, T, Ungar, D, Lupashin, V, Schönherr, R, Willett, R, Duden, R, Pokrovskaya, I	Nat Commun	2013
18086915	Interaction of the conserved oligomeric Golgi complex with t-SNARE Syntaxin5a/Sed5 enhances intra-Golgi SNARE complex stability Shestakova, A, Suvorova, E, Pavliv, O, Lupashin, V, Khaidakova, G	J. Cell Biol.	2007
23839779	The Golgi puppet master: COG complex at center stage of membrane trafficking interactions Ungar, D, Lupashin, V, Willett, R	Histochem. Cell Biol.	2013