MAPKs phosphorylate PP2A

Stable Identifier
R-HSA-6811454
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Activated MAPK1 (ERK2) or MAPK3 (ERK1), recruited to the PP2A complex through IER3 (IEX-1), phosphorylate the regulatory subunit PPP2R5B (B56-beta) or PPP2R5C (B56-gamma) of the PP2A complex on serine residue S368 or S337, respectively. ERK-mediated phosphorylation of the PP2A regulatory subunits causes dissociation of the PP2A complex and prevents PP2A-mediated dephosphorylation of AKT1 (Letourneux et al. 2006, Rocher et al. 2007).
Literature References
PubMed ID Title Journal Year
16456541 B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

Rocher, G, Porteu, F, Letourneux, C

EMBO J 2006
17200115 Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity

Rocher, G, Letourneux, C, Porteu, F, Lenormand, P

J. Biol. Chem. 2007
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of PP2A-B56-beta,gamma:IER3:p-T,Y-MAPK dimers [cytosol]

Orthologous Events
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