Reactome | MAPKs phosphorylate PP2A

MAPKs phosphorylate PP2A

Stable Identifier

R-HSA-6811454

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated MAPK1 (ERK2) or MAPK3 (ERK1), recruited to the PP2A complex through IER3 (IEX-1), phosphorylate the regulatory subunit PPP2R5B (B56-beta) or PPP2R5C (B56-gamma) of the PP2A complex on serine residue S368 or S337, respectively. ERK-mediated phosphorylation of the PP2A regulatory subunits causes dissociation of the PP2A complex and prevents PP2A-mediated dephosphorylation of AKT1 (Letourneux et al. 2006, Rocher et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
16456541	B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK Rocher, G, Porteu, F, Letourneux, C	EMBO J	2006
17200115	Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity Rocher, G, Letourneux, C, Porteu, F, Lenormand, P	J. Biol. Chem.	2007