Reactome | TGM1 [cytosol]

TGM1 [cytosol]

Stable Identifier

R-HSA-6813756

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein-glutamine gamma-glutamyltransferase K ecNumber2.3.2.13/ecNumber, TGM1_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Keratinization (Homo sapiens)
  - Formation of the cornified envelope (Homo sapiens)
    - CASP14 cleaves filaggrin (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
    - CDSN binds the cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
    - Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking (Homo sapiens)
      - EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
      - IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
    - Lamellar bodies bind the early cornified envelope (Homo sapiens)
      - Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
    - Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
      - Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
      - Late cornified envelope [plasma membrane] (Homo sapiens)
        
        Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        Cornified envelope [plasma membrane] (Homo sapiens)
        
        Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
    - Plasma membrane resorption (Homo sapiens)
      - Mature cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
        
        No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
        
        No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
    - Reinforcement of the Cornified Envelope (Homo sapiens)
      - EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
      - Early cornified envelope [plasma membrane] (Homo sapiens)
        
        EVPL:PPL:IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
    - TGM1 and involucrin bind the plasma membrane (Homo sapiens)
      - IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)
        
        TGM1 [cytosol] (Homo sapiens)
      - TGM1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P22735 TGM1

Gene Names

TGM1, KTG

Chain

chain:1-817

Reference Genes

BioGPS Gene:7051 TGM1

COSMIC (genes):TGM1 TGM1

CTD Gene:7051 TGM1

dbSNP Gene:7051 TGM1

ENSEMBL:ENSG00000092295 TGM1

HGNC:11777 TGM1

Monarch:7051 TGM1

NCBI Gene:7051 TGM1

OMIM:190195 TGM1

UCSC:P22735 TGM1

Reference Transcript

RefSeq:NM_000359.2 TGM1

Other Identifiers

11741819_a_at

16791219

206008_PM_at

206008_at

3558044

3558045

3558046

3558047

3558048

3558049

3558050

3558051

3558052

3558054

3558055

3558056

3558058

3558059

3558060

3558061

3558062

3558063

3558064

3558065

3558066

3558067

3558070

3558072

35947_at

7051

7978222

A_23_P65618

GE58185

GO:0001533

GO:0003810

GO:0003824

GO:0005515

GO:0005829

GO:0005886

GO:0010838

GO:0016020

GO:0016740

GO:0016746

GO:0018149

GO:0030154

GO:0030216

GO:0031424

GO:0036211

GO:0042802

GO:0043163

GO:0043226

GO:0045787

GO:0046872

GO:0070062

GO:0140096

HMNXSV003034728

ILMN_1721134

M98447_rna1_at

TC14000971.hg

g4507474_3p_at

g4507474_3p_x_at

Participates

as an input of

TGM1 and involucrin bind the plasma membrane (Homo sapiens)

as a component of

IVL:TGM1:Cell surface [plasma membrane] (Homo sapiens)

Other forms of this molecule

TGM1 [cornified envelope]

TGM1 [plasma membrane]

Inferred To

TGM1 [cytosol] (Bos taurus)

TGM1 [cytosol] (Canis familiaris)

TGM1 [cytosol] (Danio rerio)

TGM1 [cytosol] (Drosophila melanogaster)

TGM1 [cytosol] (Mus musculus)

TGM1 [cytosol] (Rattus norvegicus)

TGM1 [cytosol] (Sus scrofa)

TGM1 [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000092295

ENSEMBL

ENSP00000206765, ENSP00000439446, ENSP00000496483, ENST00000206765, ENST00000646057, ENST00000642845, ENSP00000493587, ENST00000544573

ZINC - Substances

TGM1_HUMAN

ZINC - Biogenic

TGM1_HUMAN

ZINC target

P22735

PRO

P22735

GlyGen

P22735

PDB

2XZZ

IntEnz

2.3.2.13

HPA

ENSG00000092295-TGM1

Pharos - Targets

P22735

Orphanet

TGM1

ZINC - Predictions - Purchasable

TGM1_HUMAN

HMDB Protein

HMDBP00682

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5Y2 NUBP2	1	NUBP2 [cytosol] (R-HSA-2564767)	0.556	3
UniProt:Q8IW00 VSTM4			0.556	3
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q5TA78 LCE4A	1	LCE4A [cytosol] (R-HSA-6814272)	0.556	3
UniProt:Q5TA76 LCE3A	1	LCE3A [cytosol] (R-HSA-6814296)	0.556	3
UniProt:Q5T7P3 LCE1B	1	LCE1B [cytosol] (R-HSA-6814271)	0.556	3
UniProt:Q5T753 LCE1E	1	LCE1E [cytosol] (R-HSA-6814299)	0.556	3
UniProt:Q14162 SCARF1	2	SCARF1 [plasma membrane] (R-HSA-2197636) SCARF1 [endocytic vesicle membrane] (R-HSA-2239453)	0.556	3
UniProt:Q9BXJ1-2 C1QTNF1			0.556	6
UniProt:P05187 ALPP	1	ALPP [transport vesicle] (R-HSA-8847823)	0.556	3
UniProt:CXCL16 A0A6I8PIU0			0.556	3
UniProt:Q969P0 IGSF8			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:Q92608 DOCK2	3	DOCK2 [specific granule lumen] (R-HSA-6799558) DOCK2 [extracellular region] (R-HSA-6806310) DOCK2 [cytosol] (R-HSA-200938)	0.556	3
UniProt:P13284 IFI30	1	IFI30 [lysosomal lumen] (R-HSA-1031704)	0.556	3
UniProt:Q92692-2 NECTIN2			0.556	3
UniProt:Q9UGL9 CRCT1			0.556	3
UniProt:Q6EMK4 VASN			0.556	3
UniProt:Q9BR01 SULT4A1	1	SULT4A1 [cytosol] (R-HSA-176668)	0.556	3
UniProt:Q8NE01 CNNM3			0.556	3
UniProt:P28330 ACADL	1	ACADL [mitochondrial matrix] (R-HSA-49489)	0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:Q86VE0 MYPOP			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:P16144-2 ITGB4			0.556	3
UniProt:Q9BQ66 KR412			0.556	3
UniProt:P09211 GSTP1	4	GSTP1 [secretory granule lumen] (R-HSA-6801488) GSTP1 [extracellular region] (R-HSA-6806461) GSTP1 [ficolin-1-rich granule lumen] (R-HSA-6801490) GSTP1 [cytosol] (R-HSA-176051)	0.556	3
UniProt:Q8WVR3 TPC14			0.556	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:B2RWP4 B2RWP4			0.556	3
UniProt:Q15040 JOSD1	1	JOSD1 [cytosol] (R-HSA-5688784)	0.556	3
UniProt:Q96ER9 MITOK			0.527	2
UniProt:O75752 B3GALNT1	1	B3GALNT1 [Golgi membrane] (R-HSA-8878918)	0.527	2
UniProt:O43918 AIRE			0.527	2
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.527	2
UniProt:P01160 NPPA	5	NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.527	2
UniProt:P57076 CF298			0.527	2
UniProt:Q8IW40 CC103			0.527	2
UniProt:O43309 ZSC12			0.527	2
UniProt:O95872 GPAN1			0.527	2
UniProt:Q96IK5 GMCL1			0.527	2
UniProt:Q9NU19 TB22B			0.527	2
UniProt:Q15233 NONO			0.527	2
UniProt:P02794 FTH1	5	FTH1 [cytosol] (R-HSA-434212) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [extracellular region] (R-HSA-2187212) FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [endocytic vesicle lumen] (R-HSA-2299670)	0.527	2