Reactome | ARFIP2 [cytosol]

ARFIP2 [cytosol]

Stable Identifier

R-HSA-6813848

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Arfaptin-2, ADP-ribosylation factor-interacting protein 2, Partner of RAC1, POR1

Locations in the PathwayBrowser for interactor UniProt:P08247 SYP

Expand all

External Reference Information

External Reference

UniProt:P53365 ARFIP2

Gene Names

ARFIP2, POR1

Chain

chain:1-341

Reference Genes

BioGPS Gene:23647 ARFIP2

COSMIC (genes):ARFIP2 ARFIP2

CTD Gene:23647 ARFIP2

dbSNP Gene:23647 ARFIP2

ENSEMBL:ENSG00000132254 ARFIP2

ENSEMBL_homo_sapiens_GENE:ENSG00000132254.13 ARFIP2

HGNC:17160 ARFIP2

KEGG Gene (Homo sapiens):23647 ARFIP2

Monarch:23647 ARFIP2

NCBI Gene:23647 ARFIP2

OMIM:601638 ARFIP2

UCSC:P53365 ARFIP2

Reference Transcript

Other Identifiers

11739098_x_at

11747685_a_at

11747686_x_at

11748522_a_at

11749818_x_at

11751428_a_at

11756295_x_at

16735102

202109_PM_at

202109_at

23647

3360940

3360942

3360943

3360944

3360945

3360947

3360948

3360952

3360953

3360955

3360956

3360962

3360963

3360964

3360968

36193_at

42763_at

7946201

A_23_P139228

GE59231

GO:0000423

GO:0001726

GO:0005515

GO:0005525

GO:0005543

GO:0005634

GO:0005730

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0005938

GO:0006886

GO:0006914

GO:0007005

GO:0007010

GO:0007264

GO:0008289

GO:0016020

GO:0019904

GO:0023052

GO:0030032

GO:0030036

GO:0030742

GO:0031267

GO:0031529

GO:0032588

GO:0034315

GO:0034497

GO:0042802

GO:0043226

GO:0043231

GO:0045296

GO:0070273

GO:0140090

HMNXSV003051331

ILMN_1750690

PH_hs_0004279

TC11001358.hg

U52522_at

g6912601_3p_at

Participates

as a component of

ARFIP2:MyrG-ARL1:GTP [cytosol] (Homo sapiens)

as an input of

ARL1:GTP binds ARFIP2 (Homo sapiens)

Inferred To

Arfip [cytosol] (Drosophila melanogaster)

ARFIP2 [cytosol] (Bos taurus)

ARFIP2 [cytosol] (Caenorhabditis elegans)

ARFIP2 [cytosol] (Canis familiaris)

ARFIP2 [cytosol] (Gallus gallus)

Arfip2 [cytosol] (Mus musculus)

Arfip2 [cytosol] (Rattus norvegicus)

TRIM3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001229784.1, NP_036534.1, XP_005252897.1, NP_001229785.1

OpenTargets

ENSG00000132254

HPA

ENSG00000132254-ARFIP2

GeneCards

P53365

Ensembl

ENST00000396777, ENST00000423813, ENSG00000132254, ENSP00000379998, ENSP00000398375, ENSP00000254584, ENST00000254584, ENSP00000391427, ENST00000445086

PRO

P53365

Pharos - Targets

P53365

HMDB Protein

HMDBP08309

PDB

1I49, 1I4L, 1I4T, 1I4D, 4DCN

Interactors (57)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.911	13
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.83	10
UniProt:P53367 ARFP1			0.75	7
UniProt:Q9Y371 SHLB1			0.718	6
UniProt:Q969L2 MAL2			0.718	6
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.718	6
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.666	4
UniProt:Q13352 ITGB3BP	2	ITGB3BP [cytosol] (R-HSA-3006405) ITGB3BP [nucleoplasm] (R-HSA-606325)	0.666	4
UniProt:P84077 ARF1	2	ARF1 [cytosol] (R-HSA-200826) ARF1 [Golgi membrane] (R-HSA-199971)	0.621	3
UniProt:P62330 ARF6	2	ARF6 [recycling endosome membrane] (R-HSA-2029049) ARF6 [cytosol] (R-HSA-8871121)	0.57	4
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q8WV15 T255B			0.556	3
UniProt:Q9NQG6 MID51			0.556	3
UniProt:Q9H7Z3 NRDE2			0.556	3
UniProt:P60763 RAC3	3	RAC3 [endoplasmic reticulum membrane] (R-HSA-9714693) RAC3 [plasma membrane] (R-HSA-195338) RAC3 [cytosol] (R-HSA-195335)	0.556	3
UniProt:Q96KN3 PKNX2			0.556	5
UniProt:Q04941 PLP2			0.556	5
UniProt:Q8WYH8 ING5	1	ING5 [nucleoplasm] (R-HSA-3215169)	0.556	3
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.556	3
UniProt:Q2KHT4-3 GSG1			0.556	3
UniProt:P37198 NUP62	2	NUP62 [cytosol] (R-HSA-9634226) NUP62 [nuclear envelope] (R-HSA-157713)	0.556	3
UniProt:Q96C03-3 MIEF2			0.556	3
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:O43739-2 CYTH3			0.556	3
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.556	3
UniProt:Q92730 RND1	1	RND1 [plasma membrane] (R-HSA-396949)	0.556	3
UniProt:P30405 PPIF			0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:P15153 RAC2	5	RAC2 [endoplasmic reticulum membrane] (R-HSA-9714482) RAC2 [mitochondrial outer membrane] (R-HSA-9714496) RAC2 [phagocytic vesicle membrane] (R-HSA-5668620) RAC2 [cytosol] (R-HSA-195343) RAC2 [plasma membrane] (R-HSA-195339)	0.556	3
UniProt:Q8TAC9 SCAM5			0.556	3
UniProt:Q00765 REEP5			0.556	3
UniProt:Q13352-5 ITGB3BP			0.556	3
UniProt:Q8N9I5 FADS6			0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.556	3
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.556	3
UniProt:P51861 CDR1			0.556	3
UniProt:A1L4K1 FSD2			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q9H0W8 SMG9	1	SMG9 [cytosol] (R-HSA-927812)	0.556	3
UniProt:Q9ULP0-2 NDRG4			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q9UFG5 CS025			0.556	3
UniProt:Q6QNY1 BL1S2			0.556	3
UniProt:P08247 SYP	1	SYP [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-5215991)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P49638 TTPA	1	TTPA [cytosol] (R-HSA-2980979)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:O95274 LYPD3	2	cleaved GPI-LYPD3 [extracellular region] (R-HSA-8941013) GPI-LYPD3 [plasma membrane] (R-HSA-8940752)	0.527	2
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.508	2

Cite Us!