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GCC2 [cytosol]
Stable Identifier
R-HSA-6813880
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GCC185, GRIP and coiled-coil domain-containing protein 2 , 185 kDa Golgi coiled-coil protein, CLL-associated antigen KW-11, CTCL tumor antigen se1-1, Ran-binding protein 2-like 4, RanBP2L4, Renal carcinoma antigen NY-REN-53
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Retrograde transport at the Trans-Golgi-Network (Homo sapiens)
ARL1 recruits TGN Golgin homodimers (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
TGN Golgin dimers [cytosol] (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
TGN Golgin dimers [cytosol] (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
Fusion of early-endosome derived vesicles at the TGN (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
TGN Golgin dimers [cytosol] (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
TGN Golgin dimers [cytosol] (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
Fusion of late-endosome derived vesicles at the TGN (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
TGN Golgin dimers [cytosol] (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] (Homo sapiens)
TGN Golgin dimers [cytosol] (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
RAB9:GTP:p-RABEPK:VAMP3:STX16:STX10:VTI1A:GARP complex:GCC2 dimer:late-endosome-to-TGN cargo [trans-Golgi network membrane] (Homo sapiens)
GCC2 dimer [cytosol] (Homo sapiens)
GCC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IWJ2 GCC2
Gene Names
GCC2, KIAA0336, RANBP2L4
Chain
chain:1-1684
Reference Genes
BioGPS Gene:9648 GCC2
COSMIC (genes):GCC2 GCC2
CTD Gene:9648 GCC2
dbSNP Gene:9648 GCC2
ENSEMBL:ENSG00000135968 GCC2
ENSEMBL:ENSG00000135968.22 GCC2
HGNC:23218 GCC2
KEGG Gene (Homo sapiens):9648 GCC2
Monarch:9648 GCC2
NCBI Gene:9648 GCC2
OMIM:612711 GCC2
UCSC:Q8IWJ2 GCC2
Reference Transcript
RefSeq:XM_006712871.1 GCC2
RefSeq:NM_181453.3 GCC2
Other Identifiers
11719350_a_at
11719351_s_at
11719352_x_at
11719353_s_at
11740762_s_at
11752004_s_at
16884062
202832_3p_at
202832_PM_at
202832_at
210676_PM_x_at
231383_PM_at
231383_at
2492318
2492320
2492336
2492337
2492338
2498769
2498770
2498771
2498985
2498987
2498988
2498990
2498991
2498993
2498994
2498995
2498996
2498997
2498998
2498999
2499000
2499002
2499003
2499004
2499006
2499007
2499009
2499011
2499012
2499013
2499014
2499015
2499016
2499017
2499018
2499019
2499021
2499024
2499025
2499026
2499653
2499655
2499657
2499659
2499661
2499662
2499698
2499701
2563411
2563412
2563419
2563421
2563423
2563424
2563425
2569086
2569090
2569091
2569092
2569093
2570467
2570468
2570469
2570471
2570474
2570476
2570479
2570524
2571276
2571278
2571281
2571284
2571291
2571293
2571297
41174_at
64362_at
76559_at
8044236
9648
A_23_P384085
A_24_P290502
A_24_P85942
A_33_P3247933
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005802
GO:0005829
GO:0006622
GO:0006886
GO:0007010
GO:0015031
GO:0016020
GO:0016192
GO:0031023
GO:0031267
GO:0034067
GO:0034453
GO:0034499
GO:0042147
GO:0042802
GO:0043226
GO:0070861
GO:0071955
GO:0090161
HMNXSV003051806
Hs.128818.0.A1_3p_at
ILMN_1654195
ILMN_1678831
ILMN_2408730
PH_hs_0028085
TC02000666.hg
TC02003486.hg
g7662061_3p_at
g7662061_3p_s_at
g7662061_3p_x_at
Participates
as a component of
GCC2 dimer [cytosol] (Homo sapiens)
Other forms of this molecule
GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol]
GCC2(1-1204)-ALK(1059-1620) fusion [cytosol]
Inferred To
GCC185 [cytosol]
(Drosophila melanogaster)
gcc2 [cytosol]
(Xenopus tropicalis)
GCC2 [cytosol]
(Bos taurus)
GCC2 [cytosol]
(Canis familiaris)
GCC2 [cytosol]
(Gallus gallus)
GCC2 [cytosol]
(Sus scrofa)
Ghost homologue of GCC2 [cytosol]
(Danio rerio)
Ghost homologue of GCC2 [cytosol]
(Dictyostelium discoideum)
Gcc2 [cytosol]
(Mus musculus)
Gcc2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_852118.1
,
XP_006712934.1
OpenTargets
ENSG00000135968
GeneCards
Q8IWJ2
HPA
ENSG00000135968-GCC2
Ensembl
ENSP00000419969
,
ENST00000482325
,
ENSP00000307939
,
ENST00000309863
,
ENSG00000135968
PRO
Q8IWJ2
Pharos - Targets
Q8IWJ2
PDB
3BBP
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20340 RAB6A
8
RAB6A [endoplasmic reticulum membrane]
(R-HSA-8849253)
RAB6A [trans-Golgi network membrane]
(R-HSA-6810981)
GGC-RAB6A [trans-Golgi network membrane]
(R-HSA-8876079)
RAB6A [Golgi membrane]
(R-HSA-1604442)
RAB6A [secretory granule membrane]
(R-HSA-6804970)
RAB6A [plasma membrane]
(R-HSA-6804981)
RAB6A [cytosol]
(R-HSA-6810979)
GGC-RAB6A [cytosol]
(R-HSA-8874052)
0.618
4
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.558
3
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