Reactome | Unfolded GNB1 [cytosol]

Unfolded GNB1 [cytosol]

Stable Identifier

R-HSA-6814200

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Unfolded G-protein subunit beta-1

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External Reference Information

External Reference

UniProt:P62873 GNB1

Gene Names

GNB1

Chain

initiator methionine:1, chain:2-340

Reference Genes

BioGPS Gene:2782 GNB1

COSMIC (genes):GNB1 GNB1

CTD Gene:2782 GNB1

dbSNP Gene:2782 GNB1

ENSEMBL:ENSG00000078369 GNB1

ENSEMBL:ENSG00000078369.19 GNB1

HGNC:4396 GNB1

KEGG Gene (Homo sapiens):2782 GNB1

Monarch:2782 GNB1

NCBI Gene:2782 GNB1

OMIM:139380 GNB1

UCSC:P62873 GNB1

Reference Transcript

Other Identifiers

11717427_a_at

11717428_s_at

200744_PM_s_at

200744_s_at

200745_PM_s_at

200745_s_at

200746_PM_s_at

200746_s_at

2391841

2391842

2391843

2391844

2391845

2391846

2391847

2391849

2391852

2391853

2391854

2391860

2391861

2391863

2391865

2391870

2391875

2391876

2391883

2391895

2391896

2391897

2391898

2782

33341_at

7911619

A_23_P22926

A_24_P71021

GO:0001750

GO:0003824

GO:0003924

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005834

GO:0005886

GO:0005929

GO:0007165

GO:0007186

GO:0007191

GO:0007200

GO:0007213

GO:0007265

GO:0008283

GO:0016020

GO:0016787

GO:0023052

GO:0030159

GO:0043226

GO:0044877

GO:0045202

GO:0048856

GO:0050877

GO:0050909

GO:0051020

GO:0060041

GO:0060090

GO:0070062

GO:0071380

GO:0071870

GO:0097381

GO:1903561

HMNXSV003027323

Hs.215595.0.A1_3p_s_at

Hs.215595.0.A2_3p_s_at

ILMN_1760320

M36430_s_at

PH_hs_0023640

TC01006298.hg

X04526_at

g11321584_3p_s_at

Participates

as a member of

Unfolded G-protein beta subunit [cytosol] (Homo sapiens)

Other forms of this molecule

GNB1 [photoreceptor disc membrane]

Partially folded GNB1 [cytosol]

GNB1 [plasma membrane]

GNB1 [cytosol]

Inferred To

GNB1 [cytosol] (Bos taurus)

GNB1 [cytosol] (Canis familiaris)

GNB1 [cytosol] (Gallus gallus)

GNB1 [cytosol] (Sus scrofa)

STE4 [cytosol] (Saccharomyces cerevisiae)

git5 [cytosol] (Schizosaccharomyces pombe)

gpb-1 [cytosol] (Caenorhabditis elegans)

Gbeta76C [cytosol] (Drosophila melanogaster)

gnb1 [cytosol] (Xenopus tropicalis)

Gbeta13F [cytosol] (Drosophila melanogaster)

Homologues of GNB1 [cytosol] (Drosophila melanogaster)

gnb1l [cytosol] (Danio rerio)

Gnb1 [cytosol] (Rattus norvegicus)

gpbA [cytosol] (Dictyostelium discoideum)

G-protein beta 1 subunit [cytosol] (Mus musculus)

Cross References

RefSeq

NP_002065.1, NP_001269468.1, XP_016856550.1, XP_016856548.1, XP_016856549.1, NP_001269467.1

OpenTargets

ENSG00000078369

HPA

ENSG00000078369-GNB1

GeneCards

P62873

Ensembl

ENSP00000481878, ENST00000610897, ENST00000378609, ENSP00000367872, ENSG00000078369

PRO

P62873

Pharos - Targets

P62873

Orphanet

25724

HMDB Protein

HMDBP08398

PDB

7T8X, 7XMR, 7CFN, 6M8S, 7Y26, 7XK2, 6N4B, 6OSA, 7WVY, 7YP7, 7U2L, 6PT0, 7F9Y, 7VV3, 7VUZ, 8HCX, 7TYX, 8FMZ, 4PNK, 7F1R, 8E3X, 7XJL, 7RTB, 7KI0, 7EO4, 7F1S, 7YON, 5HE2, 7WVX, 7F0T, 7W0N, 7WVU, 6CRK, 8ID8, 7CRH, 7XW6, 7EJA, 8HDO, 7F6G, 7RG9, 8E9Y, 7WZ7, 7YK7, 7E9G, 7U2K, 7TUZ, 7F58, 7F1O, 7EJX, 5UZ7, 5HE3, 8FN1, 7W0O, 7AUE, 7EO2, 6OS9, 7EW3, 8H8J, 6KPG, 6VCB, 7KI1, 7VUJ, 7X9C, 7XJK, 7EW4, 7WYB, 7S1M, 7X9B, 7SBF, 6WZG, 7K7L, 5UKK, 7WVV, 7X9A, 7W0L, 8HDP, 7Y27, 7L0P, 7VFX, 8DPI, 7EW1, 7EVZ, 7T6B, 7S3I, 7F9Z, 6NI3, 6X1A, 7VIH, 6LFM, 7T90, 8E3Z, 6P9X, 7WXU, 7E9H, 7BB6, 7F4H, 7F6I, 7WJ5, 7W53, 7JOZ, 7W2Z, 8E3Y, 7E2X, 6LML, 8ID4, 7BB7, 8DPF, 7RKM, 7LLL, 7TYH, 7VIG, 7RGP, 6LMK, 7TYY, 7S8L, 7WKD, 7F8V, 8G59, 7XTB, 4KFM, 8DWC, 8ID6, 7W57, 6XBJ, 7F23, 7EW7, 7EPT, 6WHA, 7SF7, 7TYF, 7S8M, 8ID9, 7VIE, 6UUS, 6B3J, 7V68, 6X19, 7C2E, 7WZ4, 7P00, 6WPW, 7VUG, 7S8O, 7W56, 7XT8, 7T9N, 6DDE, 7L0R, 7WXW, 7TZF, 7L0Q, 7UTZ, 7VUY, 7WVW, 7DB6, 7XBW, 8E9Z, 7E2Y, 7F1Q, 7YOO, 7VGX, 6UVA, 8DWG, 7W0P, 7T94, 5UKM, 7EXD, 6ORV, 7TYW, 7VUH, 7SF8, 7XBD, 7Y65, 7VUI, 6OT0, 7XT9, 7XMS, 6P9Y, 7XZ5, 8GY7, 8DPH, 7NA8, 7F4D, 8DPG, 8ID3, 7UM6, 7WU9, 7JV5, 6VMS, 7P02, 7D7M, 7WU3, 6NIY, 7XP4, 7XTC, 6OIK, 7XOW, 7TYI, 7VDL, 7X2F, 8HJ2, 6XOX, 7XOV, 7WUJ, 6WHC, 7YS6, 7S8N, 7LLY, 6D9H, 7W40, 7EZH, 7WU2, 7RKN, 7EZK, 7X2C, 7XOU, 7F53, 7T9I, 7RYC, 7XTQ, 7RMH, 7RKX, 6LFO, 7T2G, 7WUI, 7WY5, 7RKF, 6G79, 8DDW, 7F4F, 6DDF, 7TMW, 7RAN, 7WU5, 7TYL, 7NA7, 8HBD, 7XBX, 7L1V, 7WY0, 7F4I, 8DWH, 7CX2, 7VIF, 7E32, 7CX3, 8HJ0, 7L0S, 6GDG, 7E2Z, 6OIJ, 7Y67, 7WU4, 7WCM, 7XKD, 7T10, 7XTA, 7Y66, 6X18, 7V6A, 8HMV, 6XBK, 7RA3, 7F24, 7D76, 7F1Z, 7CKW, 6E3Y, 7XMT, 7L1U, 7VV5, 6XBL, 7Y64, 7T11, 7S8P, 7F6H, 7V69, 8F76, 7XZ6, 7XK8, 7W55, 7VL8, 6UUN, 8HCQ, 7VDM, 6VN7, 8HS3, 7XP6, 7EJK, 7X9Y, 7WCN, 8E9W, 7LD4, 7EJ0, 7Y24, 7WF7, 8FN0, 6OMM, 7UM7, 7EW2, 7F8W, 7Y89, 7XV3, 7EJ8, 8HSC, 7SCG, 7X2D, 7KH0, 7EVW, 7XA3, 7W0M, 7W6P, 6EG8, 5UKL, 7XW5, 7DFL, 7MTS, 5HE0, 7VDH, 7SR8, 7JVP, 7WY8, 7TYN, 7RMI, 7T2H, 7EZM, 7EVY, 7K7Z, 7CFM, 7TYO, 7RBT, 8DDX, 7EUO, 8E9X, 7YK6, 7CMU, 6WI9, 6PB0, 7X2V, 7WV9, 7CKZ, 7SRR, 7XP5, 7QVM, 7EB2, 7XOX, 7XKF, 7CMV, 7WUQ, 7W7E, 7VLA, 7XKE, 6KPF, 7JHJ, 7UM5, 8HIX, 7RMG, 7E33, 7CX4, 7LCI, 5HE1, 7VL9, 6M1I, 7JVR, 8I2G, 7W3Z, 6LI3, 6M1H, 7X5H, 7T96, 7X10, 7JVQ, 7LD3, 7CKX, 7F55, 7VKT, 7RKY, 7D77, 7F54, 6XBM, 6PB1, 7EW0, 7CKY

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:P10824 Gnai1	1	Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (R-RNO-421889)	0.488	2

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