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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
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Search ...
Go!
Unfolded GNB1 [cytosol]
Stable Identifier
R-HSA-6814200
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Unfolded G-protein subunit beta-1
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62873 GNB1
Gene Names
GNB1
Chain
initiator methionine:, chain:2-340
Reference Genes
BioGPS Gene:2782 GNB1
COSMIC (genes):GNB1 GNB1
CTD Gene:2782 GNB1
dbSNP Gene:2782 GNB1
ENSEMBL:ENSG00000078369 GNB1
ENSEMBL_homo_sapiens_GENE:ENSG00000078369.19 GNB1
HGNC:4396 GNB1
KEGG Gene (Homo sapiens):2782 GNB1
Monarch:2782 GNB1
NCBI Gene:2782 GNB1
OMIM:139380 GNB1
UCSC:P62873 GNB1
Reference Transcript
RefSeq:XM_017001061.1 GNB1
RefSeq:NM_002074.4 GNB1
RefSeq:NM_001282539.1 GNB1
RefSeq:NM_001282538.1 GNB1
RefSeq:XM_017001059.1 GNB1
RefSeq:XM_017001060.1 GNB1
Other Identifiers
11717427_a_at
11717428_s_at
200744_PM_s_at
200744_s_at
200745_PM_s_at
200745_s_at
200746_PM_s_at
200746_s_at
2391841
2391842
2391843
2391844
2391845
2391846
2391847
2391848
2391849
2391852
2391853
2391854
2391860
2391861
2391863
2391865
2391870
2391875
2391876
2391883
2391884
2391885
2391886
2391891
2391894
2391895
2391896
2391897
2391898
2391917
2782
33341_at
7911619
A_23_P22926
A_24_P71021
GE728846
GO:0001750
GO:0003824
GO:0003924
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005829
GO:0005834
GO:0005886
GO:0005929
GO:0007165
GO:0007186
GO:0007191
GO:0007200
GO:0007213
GO:0007265
GO:0008283
GO:0016020
GO:0016787
GO:0023052
GO:0030159
GO:0043226
GO:0044877
GO:0045202
GO:0048856
GO:0050877
GO:0050909
GO:0051020
GO:0060041
GO:0060090
GO:0070062
GO:0071380
GO:0071870
GO:0097381
GO:1903561
HMNXSV003027323
Hs.215595.0.A1_3p_s_at
Hs.215595.0.A2_3p_s_at
ILMN_1760320
M36430_s_at
PH_hs_0023640
TC01006298.hg
X04526_at
g11321584_3p_s_at
Participates
as a member of
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Other forms of this molecule
GNB1 [photoreceptor disc membrane]
Partially folded GNB1 [cytosol]
GNB1 [plasma membrane]
GNB1 [cytosol]
Inferred To
GNB1 [cytosol]
(Bos taurus)
GNB1 [cytosol]
(Canis familiaris)
GNB1 [cytosol]
(Gallus gallus)
GNB1 [cytosol]
(Sus scrofa)
STE4 [cytosol]
(Saccharomyces cerevisiae)
git5 [cytosol]
(Schizosaccharomyces pombe)
gpb-1 [cytosol]
(Caenorhabditis elegans)
Gbeta76C [cytosol]
(Drosophila melanogaster)
gnb1 [cytosol]
(Xenopus tropicalis)
gnb1b [cytosol]
(Danio rerio)
Gbeta13F [cytosol]
(Drosophila melanogaster)
Homologues of GNB1 [cytosol]
(Drosophila melanogaster)
Gnb1 [cytosol]
(Rattus norvegicus)
gpbA [cytosol]
(Dictyostelium discoideum)
G-protein beta 1 subunit [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_001269468.1
,
XP_016856548.1
,
XP_016856550.1
,
NP_002065.1
,
XP_016856549.1
,
NP_001269467.1
OpenTargets
ENSG00000078369
HPA
ENSG00000078369-GNB1
GeneCards
P62873
Ensembl
ENST00000703703
,
ENSP00000515432
,
ENSP00000515433
,
ENSP00000515427
,
ENSP00000515428
,
ENST00000703704
,
ENST00000703701
,
ENSP00000481878
,
ENSP00000515429
,
ENST00000610897
,
ENSP00000515445
,
ENSP00000515431
,
ENST00000703700
,
ENST00000703706
,
ENST00000703708
,
ENSP00000515438
,
ENST00000703694
,
ENST00000703696
,
ENST00000703709
,
ENST00000703693
,
ENSP00000515434
,
ENSP00000515435
,
ENST00000703702
,
ENST00000703692
,
ENSP00000515436
,
ENSP00000515437
,
ENST00000378609
,
ENSG00000078369
,
ENST00000703711
,
ENST00000703697
,
ENSP00000515443
,
ENSP00000515444
,
ENSP00000515442
,
ENSP00000367872
,
ENST00000703710
,
ENST00000703699
,
ENSP00000515440
PRO
P62873
Pharos - Targets
P62873
Orphanet
25724
HMDB Protein
HMDBP08398
PDB
8IJD
,
8GE4
,
8X2K
,
8JLZ
,
7S3I
,
7XJL
,
8THK
,
6XBJ
,
7F8V
,
7TRP
,
8HPT
,
8DWG
,
8IUL
,
6OS9
,
8XJK
,
8W8A
,
7XXH
,
8YY8
,
7SBF
,
8GDA
,
8XOF
,
8JZZ
,
7RBT
,
7F24
,
8UNR
,
7W0O
,
8IKL
,
8JLN
,
8U82
,
7F1O
,
7VDM
,
7XP5
,
7XKE
,
8J6J
,
8JHI
,
7CFM
,
8HQC
,
7YDM
,
7T2H
,
7EJ8
,
5HE2
,
8IBU
,
7EZH
,
7JVR
,
8IA8
,
7T11
,
8UNN
,
8INR
,
7L0R
,
6OT0
,
7D76
,
8KFZ
,
6X18
,
8E9W
,
8GY7
,
7BB7
,
8U4P
,
7EXD
,
7W0M
,
7EJX
,
7Y66
,
8GG7
,
6WPW
,
7XP6
,
8JR9
,
6X1A
,
7E9H
,
8GHV
,
6D9H
,
7EJK
,
8JLO
,
8FEG
,
8X79
,
8GG0
,
7XBD
,
8GUT
,
8FN1
,
7RMH
,
6M1H
,
8FX5
,
6XBL
,
9AUC
,
8IOC
,
8HQE
,
7RKN
,
7CRH
,
8T3V
,
7EZK
,
7VL8
,
7YK7
,
8IBV
,
8DZS
,
8GEI
,
8UNZ
,
8F2A
,
8JXV
,
7F8W
,
7DFL
,
7Y67
,
7X2D
,
8WC9
,
8E9X
,
8IUM
,
7EW4
,
8GG8
,
7VLA
,
6LMK
,
8F0K
,
8UNV
,
6VN7
,
8GG1
,
7X2V
,
7EVY
,
8PM2
,
8J6L
,
8IW1
,
8WC5
,
7LLL
,
8JHN
,
8HMV
,
7C2E
,
8XZH
,
8FLR
,
8SAI
,
5HE3
,
8GEJ
,
6DDF
,
7YAC
,
7TYO
,
7XTC
,
8HDO
,
7XOU
,
8JLP
,
8JD3
,
7YKD
,
7X10
,
7RG9
,
7XBW
,
7XZ6
,
7KH0
,
8IOD
,
7WJ5
,
7TYF
,
8XOG
,
7TZF
,
7VIH
,
6OMM
,
7RKX
,
7RMI
,
7TMW
,
7F9Y
,
8UO3
,
8IQ4
,
8U1U
,
8THL
,
8J6P
,
8GFV
,
8HN8
,
5UKK
,
8GEC
,
7EW0
,
8I7V
,
8DDW
,
8FLS
,
8IC0
,
8W8B
,
7S8P
,
7E2Z
,
8HDP
,
6WZG
,
7XOV
,
8U83
,
7K7L
,
7E2X
,
7VIF
,
6OIJ
,
8GE5
,
7EB2
,
7XTQ
,
8W87
,
6PB0
,
6NI3
,
8UNS
,
8SG1
,
8KGK
,
7S8L
,
8ID3
,
7EW2
,
8WPU
,
7LCI
,
8JHY
,
7V68
,
7E33
,
8UNO
,
8J18
,
8GED
,
8DDX
,
7UM5
,
8JSO
,
8IW4
,
8GDB
,
7EPT
,
7TYW
,
7VUG
,
7RGP
,
7Y27
,
8F76
,
7T96
,
9AVG
,
7F58
,
7RTB
,
8I2G
,
7VUI
,
8DPF
,
7L1V
,
7X9B
,
8GG9
,
7SF8
,
8JD5
,
8GE6
,
6WHC
,
8EIT
,
4KFM
,
7S8M
,
7TYI
,
7TYH
,
7WVW
,
8IW7
,
6LFM
,
7XT8
,
7CMU
,
8HIX
,
8XOH
,
8ID4
,
7T9N
,
8HQM
,
8DPG
,
8GGA
,
8EJC
,
8X7A
,
7W6P
,
8POK
,
8IRR
,
7WXU
,
7VUY
,
8IQ6
,
8JXW
,
7Y3G
,
8J19
,
8GDC
,
7VFX
,
7RYC
,
5UKL
,
8J6Q
,
8DZP
,
7P02
,
8F2B
,
7WZ7
,
8SL3
,
8UO0
,
8DWH
,
8U4Q
,
7F4H
,
8GG2
,
8XJL
,
7F4D
,
7WVU
,
7WY8
,
7W53
,
8T3O
,
7XXI
,
8WCA
,
8UNW
,
6GDG
,
8JII
,
7XY6
,
8J6R
,
7YON
,
8WC6
,
6N4B
,
7W56
,
6G79
,
7WUQ
,
7XT9
,
7W3Z
,
7T90
,
8G05
,
8HQN
,
7V69
,
8HJ0
,
8SZG
,
5UZ7
,
8XZI
,
7XKF
,
7CKY
,
7WY0
,
7SCG
,
7VV3
,
8U26
,
7AUE
,
8XJM
,
7CX4
,
7NA8
,
7TRQ
,
7XMR
,
8HNK
,
6KPF
,
7T6B
,
7YDP
,
8GG3
,
7WUI
,
6M1I
,
7F1S
,
7F1Q
,
7EO2
,
7X9C
,
7WCN
,
7XK2
,
7Y89
,
6UVA
,
8JLQ
,
7WU3
,
8J9N
,
7VGX
,
8JD6
,
7JHJ
,
8E3X
,
7SR8
,
7YOO
,
6P9X
,
7WU5
,
7F6G
,
8J1A
,
8IY9
,
8I7W
,
8IW9
,
8ID6
,
8E9Y
,
7F53
,
8H0P
,
8WRB
,
8IRS
,
8W8Q
,
7KI0
,
8GFW
,
7YFC
,
6UUN
,
8UO4
,
8JIL
,
8GAG
,
8I95
,
8HNL
,
7L0S
,
8GG4
,
7F0T
,
7XJJ
,
8H0Q
,
7T2G
,
7P00
,
8U84
,
9AXF
,
7TRK
,
6VCB
,
8UHB
,
8JER
,
8XOI
,
6ORV
,
7VDH
,
4PNK
,
8FLT
,
8JSP
,
7F54
,
7CFN
,
7W0N
,
7YDH
,
8U7Z
,
7XK8
,
8W88
,
7CX2
,
7LLY
,
8KH4
,
8ID8
,
7RA3
,
8E9Z
,
7W0P
,
7JV5
,
8GFX
,
8IRT
,
8GEE
,
7Y1F
,
8UNP
,
7F23
,
8UNL
,
8GDZ
,
7YAE
,
8G59
,
8SMV
,
7X5H
,
8G2Y
,
7W0L
,
8K2X
,
7RKF
,
7T10
,
8J20
,
7EJ0
,
8GE7
,
8IYH
,
8U4N
,
8FLU
,
8EMW
,
7LD3
,
8EJK
,
8WW2
,
7E9G
,
6XBM
,
7F9Z
,
8GGB
,
8JGB
,
8UNT
,
7XOW
,
7JOZ
,
6XBK
,
8HS3
,
7XV3
,
7D77
,
7U2K
,
8GEF
,
8H4I
,
6X19
,
8H2G
,
7K7Z
,
8JXX
,
7EJA
,
8KFX
,
8IYS
,
8UNX
,
8WCB
,
8JIM
,
7Y64
,
7EZM
,
6XOX
,
8GE1
,
7VL9
,
8UO1
,
7X2C
,
7EW7
,
7QVM
,
8GE8
,
7XBX
,
8ID9
,
8T3Q
,
6EG8
,
8J21
,
7XW5
,
7X2F
,
8UQO
,
6OSA
,
7RKY
,
8HSC
,
8GGC
,
8XZJ
,
8HJ1
,
7D7M
,
7BB6
,
6B3J
,
8WC7
,
8WC3
,
5HE0
,
7UM6
,
7KI1
,
8IRU
,
7VKT
,
8IEC
,
6LFO
,
8SZH
,
8GE2
,
7Y65
,
8XZF
,
8XJN
,
7RKM
,
5HE1
,
8G94
,
7JVP
,
7EW3
,
8JGF
,
7S8N
,
7L0P
,
7TYL
,
6NIY
,
7XP4
,
6LML
,
8JKB
,
8JLR
,
7WKD
,
8GCM
,
7EW1
,
7V6A
,
8HBD
,
6M8S
,
6PT0
,
7EUO
,
8HJ2
,
7F6H
,
6VMS
,
8IJ3
,
8DPH
,
8DZQ
,
5UKM
,
7UM7
,
9AYF
,
7TYX
,
8IRV
,
7EVZ
,
8VY7
,
7RMG
,
8W8R
,
7XA3
,
8GG5
,
7E32
,
8K4N
,
8I97
,
8IYW
,
8U8F
,
7YK6
,
8GFY
,
7DB6
,
8XOJ
,
8KH5
,
6OIK
,
8GCP
,
8J22
,
8W89
,
7L0Q
,
7F6I
,
7E2Y
,
8HNM
,
7VIG
,
8JLJ
,
8DPI
,
8U81
,
8HOC
,
8JT6
,
8FMZ
,
8I9A
,
8H4K
,
7MTS
,
7XTA
,
6PB1
,
8DZR
,
8UNQ
,
7XY7
,
8GUQ
,
8IED
,
8GG6
,
8IZ4
,
8KFY
,
6WHA
,
7XZ5
,
7W7E
,
7VUH
,
8ITF
,
8UNM
,
8GFZ
,
7VIE
,
8GEG
,
7CKW
,
7RAN
,
7S8O
,
8JGG
,
7TYN
,
7JVQ
,
8UNU
,
8E3Y
,
8J23
,
8JZ7
,
8IJA
,
7XMS
,
7VUJ
,
6KPG
,
8U4O
,
7T94
,
7YS6
,
6WI9
,
7WF7
,
8GE9
,
7CMV
,
7WYB
,
8H4L
,
7UTZ
,
7YFD
,
8IZB
,
7X9Y
,
7WVX
,
8IU2
,
7TYY
,
7XTB
,
7T9I
,
9ASB
,
7YP7
,
8FN0
,
7VUZ
,
8IA2
,
8F0J
,
8UNY
,
8K8J
,
6E3Y
,
7XJK
,
7F4F
,
8J6D
,
7Y24
,
8UO2
,
7WY5
,
8JXT
,
7VV5
,
8GEH
,
7X9A
,
8EMX
,
7TUZ
,
8E3Z
,
8T3S
,
7WVV
,
8IJB
,
7XMT
,
7L1U
,
8GGE
,
7CKZ
,
7SF7
,
6CRK
,
8JLK
,
7W40
,
8GEA
,
8HMP
,
7VDL
,
7T8X
,
8WC8
,
7W57
,
7CKX
,
6DDE
,
7F4I
,
7WV9
,
7WVY
,
7TRS
,
7WXW
,
8GUR
,
8XZG
,
8XJO
,
8SZI
,
7WZ4
,
7XKD
,
8WC4
,
8I9L
,
8GE3
,
7W2Z
,
7S1M
,
8IA7
,
8DWC
,
6UUS
,
8FLQ
,
7Y26
,
8JHB
,
7WCM
,
8HVI
,
7WU2
,
8HTI
,
8IUK
,
8HCQ
,
7LD4
,
7CX3
,
7NA7
,
7WUJ
,
8TB0
,
7WU4
,
7F1R
,
7F55
,
7EO4
,
8FU6
,
8J24
,
7W55
,
8HJ5
,
8GEB
,
8VY9
,
8I9S
,
8GD9
,
8HCX
,
7XW6
,
7U2L
,
7F1Z
,
8J6I
,
8H8J
,
6P9Y
,
7WU9
,
8GUS
,
7YDJ
,
7SRR
,
6LI3
,
8GGF
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P63211 GNGT1
3
S-farn-GNGT1 [photoreceptor disc membrane]
(R-HSA-2530520)
GNGT1 [photoreceptor disc membrane]
(R-HSA-55393)
GNGT1 [plasma membrane]
(R-HSA-167428)
0.621
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
0.556
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q13371 PDCL
2
p-S18,S19,S20,S25-PDCL [cytosol]
(R-HSA-6814228)
PDCL [cytosol]
(R-HSA-6813727)
0.527
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
10
UniProt:P10824 Gnai1
1
Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane]
(R-RNO-421889)
0.488
2
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