Reactome | Unfolded GNB1 [cytosol]

Unfolded GNB1 [cytosol]

Stable Identifier

R-HSA-6814200

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Unfolded G-protein subunit beta-1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62873 GNB1

Gene Names

GNB1

Chain

initiator methionine:1, chain:2-340

Reference Genes

BioGPS Gene:2782 GNB1

COSMIC (genes):GNB1 GNB1

CTD Gene:2782 GNB1

dbSNP Gene:2782 GNB1

ENSEMBL:ENSG00000078369 GNB1

HGNC:4396 GNB1

KEGG:hsa:2782 GNB1

Monarch:2782 GNB1

NCBI Gene:2782 GNB1

OMIM:139380 GNB1

UCSC:P62873 GNB1

Reference Transcript

Participates

as a member of

Unfolded G-protein beta subunit [cytosol] (Homo sapiens)

Other forms of this molecule

GNB1 [cytosol]

GNB1 [plasma membrane]

Partially folded GNB1 [cytosol]

GNB1 [photoreceptor disc membrane]

Inferred To

GNB1 [cytosol] (Bos taurus)

GNB1 [cytosol] (Canis familiaris)

GNB1 [cytosol] (Gallus gallus)

STE4 [cytosol] (Saccharomyces cerevisiae)

git5 [cytosol] (Schizosaccharomyces pombe)

gpb-1 [cytosol] (Caenorhabditis elegans)

Gbeta76C [cytosol] (Drosophila melanogaster)

gnb1 [cytosol] (Danio rerio)

gnb1 [cytosol] (Xenopus tropicalis)

gnb1b [cytosol] (Danio rerio)

Gbeta13F [cytosol] (Drosophila melanogaster)

Homologues of GNB1 [cytosol] (Danio rerio)

Homologues of GNB1 [cytosol] (Drosophila melanogaster)

Gnb1 [cytosol] (Rattus norvegicus)

gpbA [cytosol] (Dictyostelium discoideum)

G-protein beta 1 subunit [cytosol] (Mus musculus)

Cross References

RefSeq

XP_054192040.1, XP_054192036.1, XP_054192055.1, XP_047274017.1, XP_054192042.1, NP_002065.1, XP_054192045.1, XP_047274011.1, XP_047274015.1, XP_047273999.1, XP_054192053.1, XP_047274018.1, XP_047274012.1, XP_047274016.1, XP_047274005.1, XP_047274001.1, XP_016856548.1, XP_054192039.1, XP_054192037.1, XP_054192050.1, XP_047274025.1, XP_047274000.1, XP_054192048.1, XP_054192044.1, XP_016856550.1, XP_047274010.1, XP_047274013.1, XP_054192038.1, XP_047273998.1, XP_047274019.1, XP_016856549.1, XP_054192051.1, XP_054192049.1, NP_001269468.1, XP_047274024.1, XP_054192034.1, XP_054192032.1, XP_054192030.1, XP_047274014.1, XP_054192041.1, XP_054192033.1, XP_054192035.1, XP_054192054.1, XP_054192047.1, XP_047274026.1, XP_054192043.1, XP_054192056.1, XP_047274006.1, XP_047274002.1, XP_024302263.1, XP_047274027.1, XP_047274023.1, NP_001269467.1, XP_054192046.1, XP_054192052.1, XP_054192031.1

OpenTargets

ENSG00000078369

ENSEMBL

ENST00000703699, ENSP00000515427, ENSP00000515428, ENST00000703710, ENST00000703711, ENST00000703697, ENST00000378609, ENST00000703693, ENSG00000078369, ENST00000703694, ENST00000703696, ENSP00000515429, ENST00000703706, ENSP00000515431, ENST00000703692, ENST00000703708, ENST00000703709, ENSP00000515435, ENSP00000515434, ENST00000703703, ENST00000703701, ENST00000703702, ENST00000703704, ENSP00000515433, ENSP00000515432, ENST00000703700, ENSP00000515437, ENSP00000515436, ENST00000610897, ENSP00000515438, ENSP00000515442, ENSP00000367872, ENSP00000515440, ENSP00000481878, ENSP00000515445, ENSP00000515443, ENSP00000515444

GeneCards

GNB1

HPA

ENSG00000078369-GNB1

PRO

P62873

Pharos - Targets

P62873

GlyGen

P62873

Orphanet

GNB1

HMDB Protein

HMDBP08398

PDB

9K26, 8ZF6, 8IU2, 8T3Q, 7Y64, 7T2H, 8GG1, 8FLU, 6PT0, 9D61, 8JD5, 7F53, 9BIP, 7EPT, 8UO1, 8J6J, 6OMM, 8YIC, 7XTB, 9EPQ, 8W88, 8G59, 7F9Y, 7JV5, 8GE8, 8JT6, 7NA7, 7RKX, 8G2Y, 7VLA, 8IYH, 5HE1, 8IJ3, 8XGM, 7VDL, 7E9H, 8XJL, 7YK7, 7XMS, 7XOV, 6M1I, 7VGX, 8EJC, 8GEI, 8SZG, 7CKY, 7U2K, 8U4O, 8Y53, 7JOZ, 8T3S, 8WWM, 8XXZ, 8ZX5, 9IVM, 7F24, 8DZQ, 8VHF, 7T9N, 8J6I, 7EB2, 6WZG, 7TRQ, 7JHJ, 6N4B, 8X3L, 7EJA, 8IQ6, 7TZF, 8GE9, 7RMI, 8JZ7, 8VY9, 8JSP, 8YN2, 8H0P, 8H0Q, 7E33, 7W55, 8GG9, 7YON, 7VKT, 7CRH, 7YAE, 8XQO, 8W8Q, 7XZ5, 8WC6, 9BHM, 8XJK, 8UO4, 8GFV, 8GEG, 7CKW, 7VIF, 6P9Y, 8DPI, 8UH3, 8ZSJ, 8XQR, 8GG2, 8IA8, 8IUL, 8XZJ, 7F1Z, 8DZR, 8FMZ, 8ZJD, 8ZX4, 7WCM, 7SF8, 7E32, 8UO0, 7WUJ, 7TYH, 9DQJ, 5HE2, 7VUJ, 7XTQ, 7W3Z, 8DWG, 7XK2, 9IV1, 8GD9, 8UNU, 8GEE, 7X2V, 8DZP, 8G94, 8YN4, 8XIO, 8FYL, 9IQT, 8WC8, 9AST, 8XOI, 6LML, 8JSR, 9IZF, 8H4L, 7W56, 8HQM, 8E3Z, 8H4I, 9BKK, 8IJA, 8XJO, 8HNM, 7D7M, 8HS3, 7Y89, 8HVI, 9IVG, 8IBV, 7CX4, 8HBD, 8U4N, 8T3O, 8GG3, 7Y3G, 8JHN, 8ZD1, 8WWI, 9EW2, 7S8L, 8KFX, 8PJK, 8UGY, 8J6Q, 7F54, 8FLT, 8FN1, 8J6D, 6CRK, 8UNV, 7EW0, 8JLR, 9IV2, 7XTC, 7F55, 8GEC, 6NI3, 7WU5, 8F0J, 6VMS, 8U7Z, 9ERX, 7XT9, 7NA8, 7KH0, 8FYT, 7T94, 7WU2, 8DWH, 7L1U, 8U83, 7YP7, 6KPF, 8EIT, 8U1U, 7F4D, 9IY8, 8GFW, 8IED, 9IYB, 8XVE, 8UNY, 7WVU, 7CX3, 7YAC, 8GEH, 9J31, 7XBX, 8XXU, 8JPN, 8F76, 7X9B, 8GCP, 8JHI, 9K1D, 8U81, 6LFO, 7P00, 7YDM, 8XZI, 7WVY, 8K8J, 6PB0, 8I7W, 7TYX, 7F1S, 7SR8, 7EW3, 7F4I, 7CMU, 8WOG, 6XOX, 8GE4, 8WST, 7E9G, 8ZPT, 8ID9, 8DDW, 7Y26, 8SMV, 8SAI, 8WWH, 8GY7, 9JVG, 6G79, 7E2Z, 7T90, 8XOH, 7X5H, 8DPF, 6X19, 8IW7, 8ZSV, 7XA3, 8THK, 8IEC, 7XOU, 8XQF, 8UO3, 8JEI, 7F8V, 8WC3, 8GDA, 8J20, 7X9Y, 7F6I, 6XBJ, 8GEA, 8YN5, 7WXW, 8Y62, 7W7E, 9AXF, 7XBD, 8WGB, 8GUQ, 7W0O, 8XZH, 8E9Z, 7WVW, 7X2D, 8HCX, 8GGE, 7EW1, 6E3Y, 9ITB, 8XQL, 8Z7J, 8IW1, 8IRR, 7L0R, 7RTB, 7TUZ, 8ID3, 7S8O, 8ZR5, 9IJ9, 8JLK, 8SZH, 8PM2, 7XXI, 8WWJ, 7RBT, 7E2Y, 8J18, 8ZFZ, 6OS9, 8XOF, 8F2B, 8FLQ, 8J6R, 8H4K, 7WUI, 8UNX, 8GDB, 8UNO, 8HJ1, 8WPU, 7XP4, 8J24, 7VUI, 7V69, 9AUC, 7WY5, 7F6G, 8W8B, 8I95, 7XJK, 7U2L, 7TYO, 8E9Y, 8GUS, 9GE3, 6LFM, 8XZG, 8UNM, 6UUS, 7RKM, 7T6B, 8GGB, 7XXH, 8UHB, 8UXV, 9AYF, 8K9L, 7UM7, 7RMG, 8X8N, 8YNA, 8FU6, 7Y24, 8K4N, 8JIM, 8IA7, 7XW6, 8XX3, 7JVP, 7LD3, 8JZZ, 7JVR, 8Y45, 6VCB, 7D77, 7XZ6, 8WC9, 9IZH, 8WC4, 8UNQ, 9BI6, 7XKE, 5UKM, 8HIX, 7WF7, 6OIK, 7F0T, 8IYW, 8Y01, 8YW3, 7F1O, 7SCG, 7YKD, 8KGK, 8GUT, 7EVZ, 6WHC, 8I7V, 7F8W, 7DFL, 8GGA, 7VDM, 6VN7, 8HQC, 8K3Z, 7RAN, 8JXV, 7EO2, 6OT0, 9L3W, 7YDJ, 8VY7, 6ORV, 8IKG, 7UM5, 8ZFA, 8JII, 8YN9, 8HOC, 8WCA, 7BB6, 6DDE, 8IC0, 8JJP, 8K6M, 7T11, 8XIQ, 7YFC, 6X18, 8HJ5, 8IW9, 6GDG, 8W89, 7LLL, 8JD6, 8HJ2, 7F58, 8J9N, 8J22, 8GEJ, 9BHL, 9K27, 8IRS, 7EZH, 5HE0, 5UKK, 8GG5, 4PNK, 8UUJ, 6D9H, 7EJ0, 8WW2, 8KGG, 8JD3, 7Y1F, 8XXX, 7W57, 8HQE, 8RQL, 7YOO, 8XGU, 8HTI, 8XGS, 8GG8, 8JLN, 8UNZ, 6P9X, 6LI3, 6WPW, 7YK6, 7XMT, 7EXD, 6M1H, 8JHY, 8XJM, 8Y52, 8XYK, 7UM6, 9GYO, 7WZ4, 8U4P, 8ZJG, 7VUZ, 8FLR, 7LLY, 8XWQ, 8KFY, 7WZ7, 8EMX, 8IOC, 7F23, 8YW5, 8H2G, 8HDO, 7TRS, 8JLZ, 9EPP, 6UUN, 8FY8, 8TYW, 8W87, 7RMH, 7RGP, 7F9Z, 6EG8, 9B65, 8HSC, 8U02, 7EUO, 7RKY, 8K4O, 7JVQ, 7X2F, 7Y66, 8THL, 9ITE, 8GFX, 8K4S, 7VL8, 7WUQ, 7VDH, 9BKJ, 6WI9, 8XJN, 8JLO, 8XXR, 8W8R, 8UNS, 9BQJ, 7CKZ, 8FEG, 8GEF, 8ZF9, 7KI0, 8U4Q, 8GG6, 8JSO, 7SRR, 8T3V, 8FLS, 8XQS, 7VV5, 8KH5, 8XX7, 6NIY, 9GE2, 7RKN, 7EJK, 7TRK, 8IQ4, 6B3J, 8GE6, 8ITF, 7W40, 8ZSS, 8K6N, 8XIP, 7T96, 7L1V, 7W0M, 7TYW, 8XOJ, 8JGF, 6KPG, 8K2X, 7EW7, 7F1Q, 8GE2, 8XQP, 8GFY, 7CFM, 8WRB, 8ZPS, 8E3Y, 8HNL, 8UY0, 8UWL, 7VUY, 8YY8, 7WYB, 8IBU, 8DDX, 8DPH, 7VIG, 8Y51, 8WWL, 8I9L, 8XML, 7YFD, 8X2K, 7T9I, 8XVI, 8IRT, 8YW4, 8IW4, 7YDP, 8J6P, 7TYI, 7WCN, 5HE3, 7SF7, 9DQH, 7W6P, 7K7Z, 8XXH, 8ZRK, 6UVA, 8GEB, 8YRG, 8YN3, 8GHV, 7XT8, 8G05, 7DB6, 7WU3, 7T8X, 8FYX, 7EJX, 9B54, 8TZQ, 8XOG, 9ASB, 7TMW, 8GE3, 8HQN, 8JER, 8IJB, 8GFZ, 7XV3, 7F4H, 7CFN, 8HNK, 9AVG, 8ZSP, 7V6A, 8XGO, 7CX2, 8WWN, 8DZS, 8GG0, 8ZJE, 8ZQE, 7S8N, 8XWP, 8IUM, 8I2G, 8FN0, 8KFZ, 7MTS, 7XK8, 8UNP, 7TRP, 7K7L, 7L0S, 7WU9, 8U84, 6XBL, 8JZP, 8DWC, 8J1A, 8YUV, 8YN7, 8UQO, 8ID8, 8SZI, 8Y0N, 7VIE, 6DDF, 8WSS, 8UYQ, 8WWK, 8QJ2, 8DPG, 7W2Z, 7XMR, 7VUH, 8XQE, 8UNR, 8J23, 7X9A, 7WY8, 8XWV, 8U82, 6XBM, 8I9A, 7WJ5, 8YUU, 8F0K, 8YN8, 7XBW, 8INR, 8XXV, 7XTA, 6WHA, 8GCM, 7EZK, 7S8P, 9K1C, 8IZ4, 7WVX, 7W0N, 8U8F, 8VVG, 8IUK, 8HN8, 7TYY, 7EW4, 9IIX, 7S1M, 8IY9, 8GE5, 7CMV, 7X2C, 7F4F, 8XVH, 7L0P, 8SL3, 8GDZ, 7S8M, 7YS6, 8ID4, 8W8A, 7VIH, 8JLJ, 8XYD, 8J19, 7E2X, 7D76, 7C2E, 7Y27, 8WCB, 5UZ7, 8UNL, 7VFX, 8J6L, 8HJ0, 7XP6, 8UNW, 7X10, 8J21, 8IKL, 7RA3, 8FYE, 7BB7, 7WXU, 7V68, 7F6H, 8GED, 6XBK, 8YN6, 7XOW, 7XKD, 7WVV, 8E9W, 7W0L, 8VVF, 7TYN, 8JHB, 8HMP, 7EW2, 8HDP, 8IJD, 8JXT, 8JR9, 7W53, 6OIJ, 9L3Y, 7L0Q, 7UTZ, 7W0P, 8ID6, 7AUE, 8K4P, 7S3I, 8PKM, 8JIL, 7WKD, 8E3X, 8X7A, 7Y67, 7LD4, 7T10, 8IRV, 7VL9, 6OSA, 6X1A, 7QVM, 8I9S, 8H8J, 8XQN, 7XJL, 9JKQ, 9IZG, 8JLP, 8WJX, 8WC7, 8GDC, 7X9C, 8UNT, 5UKL, 7CKX, 8Y63, 8GG7, 7WY0, 7EZM, 8I97, 7RKF, 7KI1, 8IYS, 7RYC, 8HCQ, 7LCI, 8XQT, 7TYL, 7VV3, 8UNN, 8GUR, 7WV9, 8E9X, 8VVE, 8EMW, 8KH4, 4KFM, 7XY6, 8U26, 8GGC, 6PB1, 8JGB, 8JXX, 8POK, 7EO4, 8IRU, 8JKB, 8IKH, 8IZB, 7XW5, 7XKF, 8XIR, 7Y65, 8K6O, 7WU4, 8WP1, 8UTD, 8X79, 8F2A, 8FX5, 6M8S, 8HMV, 8WC5, 8JLQ, 8JEF, 8GAG, 7SBF, 8V6U, 8YUT, 7XP5, 8XX6, 8UO2, 8GG4, 8IA2, 7EJ8, 8SG1, 8JPP, 7T2G, 6LMK, 7P02, 7YDH, 8XZF, 7TYF, 7EVY, 7VUG, 8GGF, 7RG9, 7XJJ, 7F1R, 8HPT, 7XY7, 8GE1, 8TB0, 8JXW, 8JGG, 8YKY, 8EJK, 8GE7, 8UXY, 8IOD, 8ZFC, 8K9K, 8X8L

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q13371 PDCL	2	p-S18,S19,S20,S25-PDCL [cytosol] (R-HSA-6814228) PDCL [cytosol] (R-HSA-6813727)	0.643	4
UniProt:P63211 GNGT1	3	S-farn-GNGT1 [photoreceptor disc membrane] (R-HSA-2530520) GNGT1 [photoreceptor disc membrane] (R-HSA-55393) GNGT1 [plasma membrane] (R-HSA-167428)	0.621	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.527	10
UniProt:P10824 Gnai1	1	Guanine nucleotide-binding protein G(i), alpha-1 subunit [plasma membrane] (R-RNO-421889)	0.488	2

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