CK2 phosphorylates PDCL

Stable Identifier
R-HSA-6814409
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Casein kinase II complex phosphorylates PhLP
ReviewStatus
5/5
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CK2 phosphorylates PDCL
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The casein kinase II (CK2) complex phosphorylates PDCL (PhLP1) at the N-terminal serine residues S18, S19, S20 and S25. The phosphorylation at S20 is the most critical for PDCL-mediated folding of the G-protein beta subunit (Lukov et al. 2005, Lukov et al. 2006).
Literature References
PubMed ID Title Journal Year
16717095 Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex

Thulin, CD, Lukov, GL, Ludtke, PJ, Hu, T, Carter, MD, Baker, CM, Hackett, RA, Willardson, BM

J. Biol. Chem. 2006
15889144 Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly

Lukov, GL, Hu, T, Hamm, HE, McLaughlin, JN, Willardson, BM

EMBO J. 2005
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of Casein kinase II [cytosol]

Physical Entity
Casein kinase II [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CK2 phosphorylates PDCL (Bos taurus)
CK2 phosphorylates PDCL (Caenorhabditis elegans)
CK2 phosphorylates PDCL (Canis familiaris)
CK2 phosphorylates PDCL (Drosophila melanogaster)
CK2 phosphorylates PDCL (Mus musculus)
CK2 phosphorylates PDCL (Rattus norvegicus)
CK2 phosphorylates PDCL (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-11-30)
Reviewed
Willardson, BM  (2015-12-22)
Created
Orlic-Milacic, M  (2015-11-26)
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