Reactome | CK2 phosphorylates PDCL

CK2 phosphorylates PDCL

Stable Identifier

R-HSA-6814409

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Casein kinase II complex phosphorylates PhLP

ReviewStatus

5/5

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The casein kinase II (CK2) complex phosphorylates PDCL (PhLP1) at the N-terminal serine residues S18, S19, S20 and S25. The phosphorylation at S20 is the most critical for PDCL-mediated folding of the G-protein beta subunit (Lukov et al. 2005, Lukov et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16717095	Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex Thulin, CD, Lukov, GL, Ludtke, PJ, Hu, T, Carter, MD, Baker, CM, Hackett, RA, Willardson, BM	J. Biol. Chem.	2006
15889144	Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly Lukov, GL, Hu, T, Hamm, HE, McLaughlin, JN, Willardson, BM	EMBO J.	2005