RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm]

Stable Identifier
R-HSA-6814534
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:Pre-snRNA:RNU1-1,RNU2-1 gene:TBP:TFIIB:TFIIA:TFIIF:snTAFc:CDK7:SNAPc:POU2F1:ZNF143
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
23932780 The little elongation complex functions at initiation and elongation phases of snRNA gene transcription

Eissenberg, JC, Smith, ER, Lin, C, Hu, D, Shilatifard, A, Gao, X, Varberg, JM, Mohaghegh, N, Florens, LA, Saraf, A, Jackson, J, Washburn, MP, Garruss, AS

Mol. Cell 2013
22137580 Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes

Laitem, C, Murphy, S, Kiss, T, Zaborowska, J, Egloff, S

Mol. Cell 2012
24997600 RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation

Mosley, AL, Young, P, Li, J, Murphy, S, Olsen, JB, Zhong, G, He, H, Hunter, GO, Emili, A, Huang, H, Xu, C, Senisterra, GA, Min, J, Ni, Z, Kuo, WH, Guo, X, Greenblatt, JF, Loppnau, P, Arrowsmith, CH, Guo, H, Marcon, E, Tempel, W, Wan, C, El Bakkouri, M, Kuznetsova, OV, Sidhu, SS

Nat. Struct. Mol. Biol. 2014
25675981 The Integrator complex controls the termination of transcription at diverse classes of gene targets

Wu, X, Hughes, SH, Florens, LA, Saraf, A, Skaar, JR, Pagano, M, Ferris, AL, Khanna, KK, Washburn, MP

Cell Res. 2015
22231121 Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B

Guo, H, Marcon, E, Young, P, Li, J, Ruan, ED, Olsen, JB, Emili, A, Zhong, G, Ni, Z, Moffat, J, Guo, X, Greenblatt, JF

Transcription 2011
Participants
components
Participates
as an input of
as an output of
This entity regulates
Positively
Inferred To
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Canis familiaris)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Danio rerio)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Drosophila melanogaster)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Gallus gallus)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Sus scrofa)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Xenopus tropicalis)
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