Reactome | PERP binds desmosomes

PERP binds desmosomes

Stable Identifier

R-HSA-6814695

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PERP (p53 effector related to PMP-22) is a p53/p63 target gene involved in DNA damage-induced apoptosis (Flores et al. 2002). It is a tetraspan membrane protein,distantly related to members of the claudin/PMP-22/EMP family of four-pass membrane proteins (Attardi et al. 2000). It has an epithelial-specific expression pattern during embryogenesis and localizes to desmosomes. Perp -/- knockout mice exhibit numerous desmosomal structural defects, suggesting a role for Perp in promoting the stable assembly of desmosomal adhesive complexes (Ihrie et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15797384	Perp is a p63-regulated gene essential for epithelial integrity Horner, JS, Nguyen, BT, Papazoglu, C, Marques, MR, Attardi, LD, Bronson, RT, Ihrie, RA, Mills, AA	Cell	2005