Reactome | ENPP6 [plasma membrane]

ENPP6 [plasma membrane]

Stable Identifier

R-HSA-6814799

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ectonucleotide pyrophosphatase/phosphodiesterase family member 6, ENPP6_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O95169 NDUFB8

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Literature References

PubMed ID	Title	Journal	Year
15788404	Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family Sakagami, H, Nishikawa, K, Arai, H, Natori, Y, Kakehi, Y, Aoki, J, Natori, Y	J. Biol. Chem.	2005

External Reference Information

External Reference

UniProt:Q6UWR7 ENPP6

Gene Names

ENPP6, UNQ1889/PRO4334

Chain

signal peptide:1-22, chain:23-419, propeptide:420-440

Reference Genes

BioGPS Gene:133121 ENPP6

COSMIC (genes):ENPP6 ENPP6

CTD Gene:133121 ENPP6

dbSNP Gene:133121 ENPP6

ENSEMBL:ENSG00000164303 ENPP6

ENSEMBL_homo_sapiens_GENE:ENSG00000164303.11 ENPP6

HGNC:23409 ENPP6

KEGG Gene (Homo sapiens):133121 ENPP6

Monarch:133121 ENPP6

NCBI Gene:133121 ENPP6

OMIM:616983 ENPP6

UCSC:Q6UWR7 ENPP6

Reference Transcript

RefSeq:NM_153343.3 ENPP6

Other Identifiers

11727071_at

11727072_at

133121

16981931

229916_PM_at

229916_at

2796242

2796243

2796244

2796245

2796246

2796247

2796253

2796266

2796268

2796272

2796273

2796287

2796299

2796300

2796301

67040_at

8103894

A_23_P121813

A_24_P397255

GE79807

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006629

GO:0008081

GO:0008889

GO:0016020

GO:0016042

GO:0016787

GO:0019695

GO:0043226

GO:0046475

GO:0046872

GO:0047390

GO:0070062

GO:0098552

HMNXSV003017956

Hs.179075.0.S1_3p_at

ILMN_1676383

PH_hs_0029671

TC04001800.hg

Inferred To

NPP1 [plasma membrane] (Saccharomyces cerevisiae)

enpp6 [plasma membrane] (Xenopus tropicalis)

Homologues of ENPP6 [plasma membrane] (Saccharomyces cerevisiae)

ENPP6 [plasma membrane] (Bos taurus)

ENPP6 [plasma membrane] (Caenorhabditis elegans)

ENPP6 [plasma membrane] (Canis familiaris)

ENPP6 [plasma membrane] (Danio rerio)

ENPP6 [plasma membrane] (Dictyostelium discoideum)

ENPP6 [plasma membrane] (Gallus gallus)

ENPP6 [plasma membrane] (Mus musculus)

ENPP6 [plasma membrane] (Rattus norvegicus)

ENPP6 [plasma membrane] (Schizosaccharomyces pombe)

ENPP6 [plasma membrane] (Sus scrofa)

NPP2 [plasma membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_699174.1

OpenTargets

ENSG00000164303

GeneCards

Q6UWR7

HPA

ENSG00000164303-ENPP6

Ensembl

ENSG00000164303, ENST00000296741, ENSP00000296741

PRO

Q6UWR7

Pharos - Targets

Q6UWR7

HMDB Protein

HMDBP10943

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12797-6 ASPH			0.556	3
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.527	2
UniProt:Q8IUI8 CRLF3			0.527	3
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.527	2
UniProt:Q9Y6M9 NDUFB9	1	NDUFB9 [mitochondrial inner membrane] (R-HSA-60176)	0.527	2
UniProt:O95169 NDUFB8	4	NDUFB8 [mitochondrial inner membrane] (R-HSA-163938) NDUFB8(1-28) [mitochondrial matrix] (R-HSA-8986166) NDUFB8(1-186) [mitochondrial inner membrane] (R-HSA-8986184) NDUFB8(1-186) [mitochondrial intermembrane space] (R-HSA-8986140)	0.527	2
UniProt:O43676 NDUFB3	1	NDUFB3 [mitochondrial inner membrane] (R-HSA-59930)	0.527	2
UniProt:Q6ZN04 MEX3B			0.527	2
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.527	2
UniProt:O15126 SCAMP1	2	SCAMP1 [plasma membrane] (R-HSA-6806161) SCAMP1 [specific granule membrane] (R-HSA-6806140)	0.527	2
UniProt:Q86T24 KAISO			0.527	2
UniProt:Q9NSV4 DIAPH3	1	DIAPH3 [cytosol] (R-HSA-5666125)	0.527	2
UniProt:O15228 GNPAT	3	GNPAT [cytosol] (R-HSA-9033129) GNPAT [peroxisomal membrane] (R-HSA-1500605) GNPAT [peroxisomal matrix] (R-HSA-53413)	0.527	2
UniProt:Q9NZJ4 SACS			0.527	2
UniProt:P03915 MT-ND5	1	MT-ND5 [mitochondrial inner membrane] (R-HSA-60565)	0.527	2

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