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SRRT [nucleoplasm]
Stable Identifier
R-HSA-6814858
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Serrate RNA effector molecule homolog, SRRT_HUMAN, ASR2, ARS2B
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
CBCAP:capped pre-snRNA [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12 [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
CBCAP:capped pre-snRNA [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nuclear RNA decay (Homo sapiens)
MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA binds the RNA exosome (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
The NEXT complex and ZC3H18 bind CBCA:m7GpppN-RNA (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA (Homo sapiens)
NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
ZC3H4:WDR82:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 (Homo sapiens)
CBCA:ZFC3H1:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA:m7GpppN-RNA [nucleoplasm] (Homo sapiens)
CBCA complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
SRRT [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXP5 SRRT
Gene Names
SRRT, ARS2, ASR2
Chain
initiator methionine:, chain:2-876
Reference Genes
BioGPS Gene:51593 SRRT
COSMIC (genes):SRRT SRRT
CTD Gene:51593 SRRT
dbSNP Gene:51593 SRRT
ENSEMBL:ENSG00000087087 SRRT
HGNC:24101 SRRT
KEGG:hsa:51593 SRRT
Monarch:51593 SRRT
NCBI Gene:51593 SRRT
OMIM:614469 SRRT
UCSC:Q9BXP5 SRRT
Reference Transcript
RefSeq:NM_001128854.1 SRRT
RefSeq:NM_015908.5 SRRT
RefSeq:NM_001128853.1 SRRT
RefSeq:NM_001128852.1 SRRT
Participates
as a component of
CBCA complex [nucleoplasm] (Homo sapiens)
CBCAP:capped snRNA U1,U2,U4,U4atac,U5,U11,U12 [nucleoplasm] (Homo sapiens)
CBCAP:capped pre-snRNA [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
as an input of
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
as an output of
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Inferred To
srrt [nucleoplasm]
(Danio rerio)
Srrt [nucleoplasm]
(Mus musculus)
Srrt [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of SRRT [nucleoplasm]
(Gallus gallus)
Ghost homologue of SRRT [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of SRRT [nucleoplasm]
(Xenopus tropicalis)
Ars2 [nucleoplasm]
(Drosophila melanogaster)
SRRT [nucleoplasm]
(Bos taurus)
SRRT [nucleoplasm]
(Caenorhabditis elegans)
SRRT [nucleoplasm]
(Canis familiaris)
SRRT [nucleoplasm]
(Dictyostelium discoideum)
SRRT [nucleoplasm]
(Plasmodium falciparum)
SRRT [nucleoplasm]
(Sus scrofa)
pir2 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
ENSEMBL
ENSP00000483556
,
ENST00000618262
,
ENST00000618411
,
ENSP00000478341
,
ENST00000614484
,
ENSP00000481173
,
ENST00000611405
,
ENSG00000087087
,
ENSP00000480421
OpenTargets
ENSG00000087087
GeneCards
SRRT
HPA
ENSG00000087087-SRRT
PRO
Q9BXP5
Pharos - Targets
Q9BXP5
GlyGen
Q9BXP5
PDB
6F7S
,
8PMP
,
6F8D
,
5OO6
,
6F7J
,
6F7P
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52298 NCBP2
2
NCBP2 [nucleoplasm]
(R-HSA-51463)
NCBP2 [cytosol]
(R-HSA-162458)
0.643
8
UniProt:Q13936 CACNA1C
1
CACNA1C [plasma membrane]
(R-HSA-265551)
0.547
2
UniProt:P62306 SNRPF
2
SNRPF [cytosol]
(R-HSA-191852)
SNRPF [nucleoplasm]
(R-HSA-71907)
0.547
2
UniProt:Q53F19 NCBP3
0.527
4
UniProt:P09234 SNRPC
1
SNRPC [nucleoplasm]
(R-HSA-8865876)
0.527
2
UniProt:Q86VM9 ZC3H18
1
ZC3H18 [nucleoplasm]
(R-HSA-9930040)
0.527
9
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.483
2
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.483
2
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