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CCND1 [cytosol]
Stable Identifier
R-HSA-68328
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
G1/S-specific cyclin D1, PRAD1 oncogene, BCL-1 oncogene
Locations in the PathwayBrowser for interactor UniProt:P42773 CDKN2C
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in cell cycle and proliferation (Homo sapiens)
MITF-M and CTNNB1-dependent CCND1 expression (Homo sapiens)
CCND1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)
CCND1 [cytosol] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 regulates WNT signaling (Homo sapiens)
Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 (Homo sapiens)
CCND1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Estrogen-responsive CCND1 gene expression (Homo sapiens)
CCND1 [cytosol] (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)
ESR1-dependent CCND1 expression (Homo sapiens)
CCND1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24385 CCND1
Gene Names
CCND1, BCL1, PRAD1
Chain
chain:1-295
Reference Genes
BioGPS Gene:595 CCND1
COSMIC (genes):CCND1 CCND1
CTD Gene:595 CCND1
dbSNP Gene:595 CCND1
ENSEMBL:ENSG00000110092 CCND1
ENSEMBL_homo_sapiens_GENE:ENSG00000110092.4 CCND1
HGNC:1582 CCND1
KEGG Gene (Homo sapiens):595 CCND1
Monarch:595 CCND1
NCBI Gene:595 CCND1
OMIM:168461 CCND1
Reference Transcript
RefSeq:NM_053056.2 CCND1
Other Identifiers
11721255_at
11721256_a_at
11721257_at
11751330_a_at
16728261
2017_s_at
2020_at
208711_PM_s_at
208711_s_at
208712_3p_at
208712_PM_at
208712_at
3338194
3338195
3338196
3338204
3338205
3338207
3338211
3338212
3338213
3338214
3338215
3338216
38418_at
595
7942123
A_14_P117958
A_23_P202837
A_24_P124550
A_24_P193011
GO:0000082
GO:0000122
GO:0000278
GO:0000307
GO:0000320
GO:0001934
GO:0003714
GO:0003824
GO:0004672
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005829
GO:0005923
GO:0006351
GO:0006355
GO:0006974
GO:0007049
GO:0007595
GO:0008283
GO:0009410
GO:0010971
GO:0012501
GO:0016020
GO:0016055
GO:0016301
GO:0016538
GO:0016740
GO:0017053
GO:0019899
GO:0019901
GO:0023052
GO:0030154
GO:0030182
GO:0030857
GO:0030968
GO:0031571
GO:0031965
GO:0033598
GO:0033601
GO:0036211
GO:0042826
GO:0043226
GO:0043524
GO:0044321
GO:0044772
GO:0045444
GO:0045737
GO:0048856
GO:0051301
GO:0051726
GO:0060749
GO:0061575
GO:0070064
GO:0070141
GO:0071310
GO:0097128
GO:0097421
GO:0098772
GO:0140096
GO:0140110
GO:2000045
HMNXSV003049250
ILMN_1688480
PH_hs_0024184
TC11000718.hg
X59798_at
g12652656_3p_s_at
g179364_3p_at
g179364_3p_x_at
Participates
as an output of
MITF-M and CTNNB1-dependent CCND1 expression (Homo sapiens)
Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 (Homo sapiens)
Estrogen-responsive CCND1 gene expression (Homo sapiens)
ESR1-dependent CCND1 expression (Homo sapiens)
Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1 (Homo sapiens)
as a component of
CDK6:CCND1 [cytosol] (Homo sapiens)
CDK4:CCND1 [cytosol] (Homo sapiens)
as a member of
Cyclin D [cytosol] (Homo sapiens)
Other forms of this molecule
CCND1 [nucleoplasm]
p-T286-CCND1 [nucleoplasm]
p-T286-CCND1 [cytosol]
Inferred To
Ccnd1 [cytosol]
(Mus musculus)
Ccnd1 [cytosol]
(Rattus norvegicus)
CCND1 [cytosol]
(Bos taurus)
CCND1 [cytosol]
(Canis familiaris)
CCND1 [cytosol]
(Gallus gallus)
CCND1 [cytosol]
(Sus scrofa)
ccnd1 [cytosol]
(Danio rerio)
ccnd1 [cytosol]
(Xenopus tropicalis)
CycD [cytosol]
(Drosophila melanogaster)
crs1 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_444284.1
OpenTargets
ENSG00000110092
GeneCards
P24385
HPA
ENSG00000110092-CCND1
Ensembl
ENST00000227507
,
ENSG00000110092
,
ENSP00000227507
PRO
P24385
Pharos - Targets
P24385
Orphanet
15408
HMDB Protein
HMDBP02156
PDB
2W9F
,
2W99
,
5VZU
,
6P8G
,
2W9Z
,
6P8E
,
2W96
,
6P8F
,
6P8H
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.985
45
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.962
25
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.905
12
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.845
8
UniProt:Q00534 CDK6
3
CDK6 [cytosol]
(R-HSA-68336)
CDK6 [nucleoplasm]
(R-HSA-141283)
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
0.839
7
IntAct:EBI-4399559 UBIQ
0.743
4
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.73
5
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.643
3
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.643
4
UniProt:Q96PU4 UHRF2
1
UHRF2 [nucleoplasm]
(R-HSA-976050)
0.602
4
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.59
2
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.576
3
UniProt:Q5XUX0 FBXO31
1
FBXO31 [cytosol]
(R-HSA-8850911)
0.576
4
UniProt:Q96TE0 Q96TE0
0.556
3
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.544
3
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.544
4
UniProt:P42773 CDKN2C
1
CDKN2C [cytosol]
(R-HSA-182572)
0.527
3
UniProt:Q07283 TCHH
2
TCHH [cornified envelope]
(R-HSA-8934848)
TCHH [cytosol]
(R-HSA-6810842)
0.527
2
UniProt:P49918 CDKN1C
3
p-Y91-CDKN1C [cytosol]
(R-HSA-8942606)
CDKN1C [cytosol]
(R-HSA-8941913)
CDKN1C [nucleoplasm]
(R-HSA-8948130)
0.527
3
UniProt:Q16656 NRF1
1
NRF1 [nucleoplasm]
(R-HSA-1592205)
0.508
2
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.499
3
UniProt:P42771 CDKN2A
20
p16INK4A D84G [cytosol]
(R-HSA-9632461)
p16INK4A E88* [cytosol]
(R-HSA-9632588)
p16INK4A R87P [cytosol]
(R-HSA-9632335)
p16INK4A V126D [cytosol]
(R-HSA-9631055)
p16INK4A W110* [cytosol]
(R-HSA-9632585)
p16INK4A D84H [cytosol]
(R-HSA-9632489)
p16INK4A R80* [cytosol]
(R-HSA-9632586)
p16INK4A P114L [cytosol]
(R-HSA-9630916)
p16INK4A R58* [cytosol]
(R-HSA-9632582)
p16INK4A D84N [cytosol]
(R-HSA-9632483)
p16INK4A M53I [cytosol]
(R-HSA-9630911)
p16INK4A D84Y [cytosol]
(R-HSA-9632478)
p16INK4A G101W [cytosol]
(R-HSA-9631257)
p16INK4A P81L [cytosol]
(R-HSA-9632280)
p16INK4A A20P [cytosol]
(R-HSA-9630805)
p16INK4A D84V [cytosol]
(R-HSA-9632465)
p16INK4A P81T [cytosol]
(R-HSA-9632275)
p16INK4A P81H [cytosol]
(R-HSA-9632293)
p16INK4A D84A [cytosol]
(R-HSA-9632486)
p16INK4A P81R [cytosol]
(R-HSA-9632294)
0.491
2
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.463
3
UniProt:Q13761 RUNX3
7
RUNX3 [nucleoplasm]
(R-HSA-8865393)
RUNX3 [cytosol]
(R-HSA-8937797)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
0.462
8
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