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DBF4 [nucleoplasm]
Stable Identifier
R-HSA-68387
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Dbf4
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
DDK [nucleoplasm] (Homo sapiens)
DBF4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBU7 DBF4
Gene Names
DBF4, ASK, DBF4A, ZDBF1
Chain
chain:1-674
Reference Genes
BioGPS Gene:10926 DBF4
COSMIC (genes):DBF4 DBF4
CTD Gene:10926 DBF4
dbSNP Gene:10926 DBF4
ENSEMBL:ENSG00000006634 DBF4
ENSEMBL_homo_sapiens_GENE:ENSG00000006634.8 DBF4
HGNC:17364 DBF4
KEGG Gene (Homo sapiens):10926 DBF4
Monarch:10926 DBF4
NCBI Gene:10926 DBF4
OMIM:604281 DBF4
UCSC:Q9UBU7 DBF4
Reference Transcript
RefSeq:NM_001318061.1 DBF4
RefSeq:NM_001318062.1 DBF4
RefSeq:NM_001318060.1 DBF4
RefSeq:NM_006716.3 DBF4
Other Identifiers
10926
11734713_s_at
11734714_at
11734715_a_at
11747731_a_at
11752175_x_at
11753043_s_at
11758032_s_at
17047965
17120506
204244_PM_s_at
204244_s_at
3011455
3011456
3011457
3011458
3011459
3011460
3011462
3011463
3011464
3011465
3011466
3011467
3011468
3011469
3011470
3011471
3011472
3011473
3011474
3011475
3011476
3011477
31865_at
3291988
3291991
3291992
3291993
3291994
3291995
8133976
A_14_P138137
A_23_P254612
A_24_P943358
GE53690
GO:0000082
GO:0000278
GO:0003676
GO:0005515
GO:0005634
GO:0005654
GO:0006260
GO:0007049
GO:0008047
GO:0008270
GO:0010571
GO:0016604
GO:0031431
GO:0043226
GO:0043539
GO:0046872
GO:0098772
GO:1901987
HMNXSV003057882
ILMN_1778717
PH_hs_0009189
TC07000524.hg
TC10002678.hg
g5729733_3p_a_at
Participates
as a component of
DDK [nucleoplasm] (Homo sapiens)
Inferred To
Dbf4 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of DBF4 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of DBF4 [nucleoplasm]
(Canis familiaris)
DBF4 [nucleoplasm]
(Bos taurus)
DBF4 [nucleoplasm]
(Dictyostelium discoideum)
DBF4 [nucleoplasm]
(Drosophila melanogaster)
DBF4 [nucleoplasm]
(Gallus gallus)
DBF4 [nucleoplasm]
(Mus musculus)
DBF4 [nucleoplasm]
(Saccharomyces cerevisiae)
DBF4 [nucleoplasm]
(Schizosaccharomyces pombe)
DBF4 [nucleoplasm]
(Sus scrofa)
DBF4 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001304991.1
,
NP_001304990.1
,
NP_006707.1
,
NP_001304989.1
OpenTargets
ENSG00000006634
GeneCards
Q9UBU7
HPA
ENSG00000006634-DBF4
Ensembl
ENSP00000414083
,
ENST00000413643
,
ENST00000265728
,
ENSP00000265728
,
ENSG00000006634
PRO
Q9UBU7
Pharos - Targets
Q9UBU7
PDB
6YA8
,
4F9C
,
4F9B
,
6YA7
,
6YA6
,
4F9A
,
4F99
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00311 CDC7
1
CDC7 [nucleoplasm]
(R-HSA-51781)
0.851
8
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P10809 HSPD1
6
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.556
3
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