Reactome | RFC5 [nucleoplasm]

RFC5 [nucleoplasm]

Stable Identifier

R-HSA-68427

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RFC36, Activator 1 36 kDa subunit (Replication factor C 36 kDa subunit) (A1 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36), Activator 1 36 kDa subunit, Replication factor C 36 kDa subunit, A1 36 kDa subunit, RF-C 36 kDa subunit, Replication factor C subunit 5

Locations in the PathwayBrowser for interactor UniProt:Q96T49 PP16B

Expand all

Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Polymerase switching on the C-strand of the telomere (Homo sapiens)
        
        Formation of the CTF18-RFC(7s) complex (Homo sapiens)
        
        RFC5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40937 RFC5

Gene Names

RFC5

Chain

chain:1-340

Reference Genes

BioGPS Gene:5985 RFC5

COSMIC (genes):RFC5 RFC5

CTD Gene:5985 RFC5

dbSNP Gene:5985 RFC5

ENSEMBL:ENSG00000111445 RFC5

HGNC:9973 RFC5

KEGG:hsa:5985 RFC5

Monarch:5985 RFC5

NCBI Gene:5985 RFC5

OMIM:600407 RFC5

UCSC:P40937 RFC5

Reference Transcript

Other Identifiers

11731418_a_at

11741284_a_at

11744232_a_at

11764033_s_at

16757687

203209_PM_at

203209_at

203210_PM_s_at

203210_s_at

213734_PM_at

213734_at

3433748

3433749

3433752

3433753

3433754

3433755

3433756

3433757

3433758

3433760

3433761

3433762

3433763

3433764

3433765

3433766

3433769

3433771

3433772

3433773

3433774

3433775

3433776

3433777

3433778

3433779

38863_at

40166_at

5985

653_at

65481_at

7959052

A_14_P103470

A_14_P112791

A_14_P127386

A_23_P95302

GE57576

GO:0003677

GO:0003689

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005663

GO:0006260

GO:0006261

GO:0006281

GO:0016787

GO:0016887

GO:0017116

GO:0019899

GO:0031390

GO:0032508

GO:0043226

GO:0140097

GO:0140657

GO:1900264

HMNXSV003017924

Hs.136644.1.A1_3p_at

ILMN_1659364

ILMN_1699709

ILMN_1803419

L07540_at

PH_hs_0025887

TC12000925.hg

g12804840_3p_at

g6677722_3p_a_at

Participates

as an input of

Formation of the CTF18-RFC(7s) complex (Homo sapiens)

as a component of

Inferred To

RFC5 [nucleoplasm] (Bos taurus)

RFC5 [nucleoplasm] (Caenorhabditis elegans)

RFC5 [nucleoplasm] (Canis familiaris)

RFC5 [nucleoplasm] (Dictyostelium discoideum)

RFC5 [nucleoplasm] (Gallus gallus)

RFC5 [nucleoplasm] (Mus musculus)

RFC5 [nucleoplasm] (Plasmodium falciparum)

RFC5 [nucleoplasm] (Saccharomyces cerevisiae)

RFC5 [nucleoplasm] (Schizosaccharomyces pombe)

RFC5 [nucleoplasm] (Sus scrofa)

RfC3 [nucleoplasm] (Drosophila melanogaster)

rfc5 [nucleoplasm] (Danio rerio)

rfc5 [nucleoplasm] (Xenopus tropicalis)

Rfc5 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_031396.1, XP_011536945.1, XP_011536947.1, NP_001123584.1, NP_001123585.1, NP_853556.2

OpenTargets

ENSG00000111445

ENSEMBL

ENST00000454402, ENST00000392542, ENSP00000408295, ENSP00000376325

HPA

ENSG00000111445-RFC5

PRO

P40937

Pharos - Targets

P40937

GlyGen

P40937

PDB

6VVO, 7Z6H

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35249 RFC4	1	RFC4 [nucleoplasm] (R-HSA-68429)	0.946	25
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.83	8
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.83	9
UniProt:O00635 TRIM38	1	TRIM38 [cytosol] (R-HSA-5624325)	0.83	8
UniProt:O75943 RAD17	1	RAD17 [nucleoplasm] (R-HSA-3008665)	0.643	4
UniProt:P35251 RFC1	1	RFC1 [nucleoplasm] (R-HSA-68435)	0.623	5
UniProt:P35250 RFC2	1	RFC2 [nucleoplasm] (R-HSA-68433)	0.564	3
IntAct:EBI-22620261 CCSB ORF ID			0.556	3
UniProt:Q9HAF1 MEAF6	1	MEAF6 [nucleoplasm] (R-HSA-3318448)	0.556	3
UniProt:Q6GPH4 XAF1	1	XAF1 [cytosol] (R-HSA-1015680)	0.556	3
UniProt:A8MTA8-2 CIMIP2B			0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:Q96T49 PP16B			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:A0A0C4DGQ7 A0A0C4DGQ7			0.556	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:P17023 ZNF19	1	ZNF19 [nucleoplasm] (R-HSA-974992)	0.556	5
UniProt:Q96B26 EXOSC8	2	EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.556	3
UniProt:O15049 N4BP3			0.556	5
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q5VWN6 TASO2			0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	5
UniProt:Q96D03 DDT4L			0.556	5
UniProt:Q9BUY5 ZNF426	1	ZNF426 [nucleoplasm] (R-HSA-1247530)	0.556	3
UniProt:Q99598 TSNAX	1	TSNAX [cytosol] (R-HSA-5216130)	0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q13285 NR5A1	3	NR5A1 [nucleoplasm] (R-HSA-452955) polySUMO2-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546383) monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546382)	0.556	3
UniProt:Q9BVC3 DSCC1	1	DSCC1 [nucleoplasm] (R-HSA-9668907)	0.527	3
UniProt:Q96QE3 ATAD5			0.527	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.527	2
UniProt:P0CG13 CHTF8	1	CHTF8 [nucleoplasm] (R-HSA-9668898)	0.527	3
UniProt:P40938 RFC3	1	RFC3 [nucleoplasm] (R-HSA-68431)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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