Reactome | RFC4 [nucleoplasm]

RFC4 [nucleoplasm]

Stable Identifier

R-HSA-68429

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RFC37, Activator 1 37 kDa subunit, Replication factor C 37 kDa subunit, A1 37 kDa subunit, RF-C 37 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:O75943 RAD17

Expand all

Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Polymerase switching on the C-strand of the telomere (Homo sapiens)
        
        Formation of the CTF18-RFC(7s) complex (Homo sapiens)
        
        RFC4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35249 RFC4

Gene Names

RFC4

Chain

chain:1-363

Reference Genes

BioGPS Gene:5984 RFC4

COSMIC (genes):RFC4 RFC4

CTD Gene:5984 RFC4

dbSNP Gene:5984 RFC4

ENSEMBL:ENSG00000163918 RFC4

HGNC:9972 RFC4

KEGG:hsa:5984 RFC4

Monarch:5984 RFC4

NCBI Gene:5984 RFC4

OMIM:102577 RFC4

UCSC:P35249 RFC4

Reference Transcript

Other Identifiers

1054_at

1055_g_at

11722872_a_at

11761625_at

11761626_x_at

16962493

204023_PM_at

204023_at

2709487

2709488

2709489

2709490

2709491

2709492

2709493

2709494

2709495

2709496

2709497

2709498

2709499

2709500

2709501

2709502

2709503

2709504

2709505

2709506

2709507

2709508

2709509

2709510

5984

8092640

A_23_P18196

GE79366

GO:0003677

GO:0003689

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005663

GO:0006260

GO:0006261

GO:0006271

GO:0006281

GO:0016787

GO:0016887

GO:0017116

GO:0031390

GO:0031391

GO:0032508

GO:0043226

GO:0140097

GO:0140657

GO:1900264

HMNXSV003037223

ILMN_1724489

ILMN_2370365

M87339_at

PH_hs_0002862

TC03002088.hg

g4506490_3p_at

Participates

as an input of

Formation of the CTF18-RFC(7s) complex (Homo sapiens)

as a component of

Inferred To

Rfc4 [nucleoplasm] (Rattus norvegicus)

RFC4 [nucleoplasm] (Bos taurus)

RFC4 [nucleoplasm] (Caenorhabditis elegans)

RFC4 [nucleoplasm] (Canis familiaris)

RFC4 [nucleoplasm] (Dictyostelium discoideum)

RFC4 [nucleoplasm] (Gallus gallus)

RFC4 [nucleoplasm] (Mus musculus)

RFC4 [nucleoplasm] (Plasmodium falciparum)

RFC4 [nucleoplasm] (Saccharomyces cerevisiae)

RFC4 [nucleoplasm] (Schizosaccharomyces pombe)

RFC4 [nucleoplasm] (Sus scrofa)

Rfc37 [nucleoplasm] (Drosophila melanogaster)

rfc4 [nucleoplasm] (Danio rerio)

rfc4 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_002907.1, NP_853551.1

OpenTargets

ENSG00000163918

ENSEMBL

ENSG00000163918, ENSP00000376272, ENSP00000296273, ENST00000296273, ENST00000392481

HPA

ENSG00000163918-RFC4

GeneCards

RFC4

PRO

P35249

Pharos - Targets

P35249

GlyGen

P35249

PDB

8UMT, 8UMV, 8UMY, 8UI9, 8UI7, 8UI8, 8UMW, 8UMU, 8UN0, 7Z6H, 8UII, 8UNJ, 6VVO

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.946	25
UniProt:P40938 RFC3	1	RFC3 [nucleoplasm] (R-HSA-68431)	0.821	14
UniProt:Q9H4P4 RNF41	1	RNF41 [cytosol] (R-HSA-975977)	0.781	7
UniProt:P35250 RFC2	1	RFC2 [nucleoplasm] (R-HSA-68433)	0.757	11
UniProt:O75943 RAD17	1	RAD17 [nucleoplasm] (R-HSA-3008665)	0.643	5
UniProt:P35251 RFC1	1	RFC1 [nucleoplasm] (R-HSA-68435)	0.623	8
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.527	2
UniProt:P54764 EPHA4	2	p-Y596,Y602-EPHA4 [plasma membrane] (R-HSA-3928352) EPHA4 [plasma membrane] (R-HSA-2682325)	0.527	2
UniProt:Q9BVC3 DSCC1	1	DSCC1 [nucleoplasm] (R-HSA-9668907)	0.527	4
UniProt:Q9HBM6 TAF9B	2	TAF9B [nucleoplasm] (R-HSA-8869460) TAF9B [nucleoplasm] (R-HSA-212404)	0.527	2
UniProt:Q96QE3 ATAD5			0.527	3
UniProt:P0CG13 CHTF8	1	CHTF8 [nucleoplasm] (R-HSA-9668898)	0.527	4
UniProt:Q14627 IL13RA2	1	IL13RA2 [extracellular region] (R-HSA-449666)	0.527	2
UniProt:Q6P1X5 TAF2	1	TAF2 [nucleoplasm] (R-HSA-212408)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9

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