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PCNA [nucleoplasm]
Stable Identifier
R-HSA-68439
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proliferating cell nuclear antigen, Cyclin
Icon
Locations in the PathwayBrowser for interactor UniProt:P06733 ENO1
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
PCNA [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
PCNA [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
SUMOylation of PCNA with SUMO1 (Homo sapiens)
PCNA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12004 PCNA
Gene Names
PCNA
Chain
chain:1-261
Reference Genes
BioGPS Gene:5111 PCNA
COSMIC (genes):PCNA PCNA
CTD Gene:5111 PCNA
dbSNP Gene:5111 PCNA
ENSEMBL:ENSG00000132646 PCNA
ENSEMBL_homo_sapiens_GENE:ENSG00000132646.11 PCNA
HGNC:8729 PCNA
KEGG Gene (Homo sapiens):5111 PCNA
Monarch:5111 PCNA
NCBI Gene:5111 PCNA
OMIM:176740 PCNA
UCSC:P12004 PCNA
Reference Transcript
RefSeq:NM_002592.2 PCNA
RefSeq:NM_182649.1 PCNA
Other Identifiers
11716103_a_at
16916958
1824_s_at
1884_s_at
201202_PM_at
201202_at
3896201
3896202
3896203
3896204
3896206
3896207
3896209
3896211
3896213
3896214
3896215
3896216
4006657
4006658
5111
8064844
A_23_P28886
A_33_P3258612
GE61312
GO:0000122
GO:0000228
GO:0000278
GO:0000307
GO:0000701
GO:0000781
GO:0000785
GO:0001673
GO:0003677
GO:0003682
GO:0003684
GO:0003824
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005652
GO:0005654
GO:0005657
GO:0005694
GO:0005813
GO:0005815
GO:0005856
GO:0006260
GO:0006272
GO:0006275
GO:0006281
GO:0006287
GO:0006298
GO:0006351
GO:0006355
GO:0006974
GO:0006979
GO:0007507
GO:0016604
GO:0016787
GO:0019899
GO:0019985
GO:0022414
GO:0030154
GO:0030331
GO:0030337
GO:0030855
GO:0030894
GO:0030971
GO:0031297
GO:0032077
GO:0032139
GO:0032200
GO:0032355
GO:0032405
GO:0033993
GO:0034644
GO:0035035
GO:0042802
GO:0043226
GO:0043596
GO:0043626
GO:0044849
GO:0044877
GO:0045739
GO:0045740
GO:0046686
GO:0048856
GO:0070062
GO:0070182
GO:0070301
GO:0070557
GO:0071466
GO:0071548
GO:0097421
GO:0098772
GO:0140097
GO:1900264
GO:1902065
GO:1902990
HMNXSV003000505
HMNXSV003026895
ILMN_1685682
ILMN_1694177
ILMN_1706958
J05614_at
M15796_at
PH_hs_0028994
TC20000592.hg
g4505640_3p_at
Participates
as an input of
SUMOylation of PCNA with SUMO1 (Homo sapiens)
as a component of
ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
MonoUb:K164-PCNA homotrimer [nucleoplasm] (Homo sapiens)
PCNA homotrimer [nucleoplasm] (Homo sapiens)
as an output of
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
Other forms of this molecule
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
K63polyUb-K164-PCNA [nucleoplasm]
ISG-K164,ISG-K168-PCNA [nucleoplasm]
MonoUb-K164-PCNA [nucleoplasm]
Inferred To
PCNA [nucleoplasm]
(Bos taurus)
PCNA [nucleoplasm]
(Canis familiaris)
PCNA [nucleoplasm]
(Drosophila melanogaster)
PCNA [nucleoplasm]
(Gallus gallus)
PCNA [nucleoplasm]
(Sus scrofa)
PCNA1 [nucleoplasm]
(Plasmodium falciparum)
pcna [nucleoplasm]
(Danio rerio)
pcna [nucleoplasm]
(Dictyostelium discoideum)
pcna [nucleoplasm]
(Xenopus tropicalis)
Pcna [nucleoplasm]
(Mus musculus)
Pcna [nucleoplasm]
(Rattus norvegicus)
POL30 [nucleoplasm]
(Saccharomyces cerevisiae)
pcn-1 [nucleoplasm]
(Caenorhabditis elegans)
pcn1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_872590.1
,
NP_002583.1
ZINC - World Drugs
PCNA_HUMAN
OpenTargets
ENSG00000132646
ZINC - FDA approved
PCNA_HUMAN
ZINC - Substances
PCNA_HUMAN
ZINC - Biogenic
PCNA_HUMAN
ZINC target
P12004
PRO
P12004
PDB
5MLW
,
1U7B
,
3WGW
,
5E0V
,
7QO1
,
6VVO
,
5MLO
,
4ZTD
,
4RJF
,
1VYJ
,
5YCO
,
5E0T
,
6TNY
,
6HVO
,
3P87
,
8GLA
,
8COB
,
3VKX
,
6GIS
,
6S1N
,
8GL9
,
7KQ1
,
7M5N
,
6CBI
,
3TBL
,
2ZVL
,
7NV0
,
7M5L
,
5MOM
,
6GWS
,
6FCM
,
5E0U
,
1UL1
,
6TNZ
,
6QCG
,
3JA9
,
2ZVK
,
7EFA
,
5YD8
,
6EHT
,
1U76
,
8F5Q
,
8B8T
,
6K3A
,
1VYM
,
4D2G
,
5IY4
,
7M5M
,
6QC0
,
6S1M
,
1AXC
,
6FCN
,
6S1O
,
1W60
,
8E84
,
5MAV
,
7QNZ
,
2ZVM
,
7KQ0
,
7NV1
ZINC - Metabolites
PCNA_HUMAN
HPA
ENSG00000132646-PCNA
GeneCards
P12004
Ensembl
ENST00000379160
,
ENSP00000368438
,
ENSP00000368458
,
ENST00000379143
,
ENSG00000132646
Pharos - Targets
P12004
Orphanet
23426
ZINC - Predictions - Purchasable
PCNA_HUMAN
Interactors (56)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P38936 CDKN1A
5
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.977
39
UniProt:P39748 FEN1
1
FEN1 [nucleoplasm]
(R-HSA-54745)
0.964
22
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.898
11
UniProt:Q15054 POLD3
1
POLD3 [nucleoplasm]
(R-HSA-68445)
0.83
7
IntAct:EBI-4399559 UBIQ
0.811
7
UniProt:Q15004 PCLAF
2
KIAA0101 [nucleoplasm]
(R-HSA-5655178)
MonoUb-K15,K24-KIAA0101 [nucleoplasm]
(R-HSA-5655182)
0.8
7
UniProt:Q13111 CAF1A
0.734
4
UniProt:P20585 MSH3
2
MSH3 K383Rfs*32 [nucleoplasm]
(R-HSA-5578664)
MSH3 [nucleoplasm]
(R-HSA-5357519)
0.718
6
UniProt:P49005 POLD2
1
POLD2 [nucleoplasm]
(R-HSA-68443)
0.678
3
UniProt:O95944 NCR2
1
NCR2 [plasma membrane]
(R-HSA-197652)
0.672
7
UniProt:P28340 POLD1
2
POLD1 [nucleoplasm]
(R-HSA-68449)
POLD1 [cytosol]
(R-HSA-2564763)
0.669
3
UniProt:A2RU14 TM218
0.666
4
UniProt:Q9Z111 GA45G
0.664
9
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.643
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
14
UniProt:P42771 CDKN2A
20
p16INK4A D84G [cytosol]
(R-HSA-9632461)
p16INK4A E88* [cytosol]
(R-HSA-9632588)
p16INK4A R87P [cytosol]
(R-HSA-9632335)
p16INK4A V126D [cytosol]
(R-HSA-9631055)
p16INK4A W110* [cytosol]
(R-HSA-9632585)
p16INK4A D84H [cytosol]
(R-HSA-9632489)
p16INK4A R80* [cytosol]
(R-HSA-9632586)
p16INK4A P114L [cytosol]
(R-HSA-9630916)
p16INK4A R58* [cytosol]
(R-HSA-9632582)
p16INK4A D84N [cytosol]
(R-HSA-9632483)
p16INK4A M53I [cytosol]
(R-HSA-9630911)
p16INK4A D84Y [cytosol]
(R-HSA-9632478)
p16INK4A G101W [cytosol]
(R-HSA-9631257)
p16INK4A P81L [cytosol]
(R-HSA-9632280)
p16INK4A A20P [cytosol]
(R-HSA-9630805)
p16INK4A D84V [cytosol]
(R-HSA-9632465)
p16INK4A P81T [cytosol]
(R-HSA-9632275)
p16INK4A P81H [cytosol]
(R-HSA-9632293)
p16INK4A D84A [cytosol]
(R-HSA-9632486)
p16INK4A P81R [cytosol]
(R-HSA-9632294)
0.61
8
UniProt:Q5FWF4 ZRAB3
0.599
8
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.59
2
UniProt:P24522 GADD45A
1
GADD45A [nucleoplasm]
(R-HSA-3215139)
0.589
3
UniProt:Q9H063 MAF1
3
p-S60,S68,S75-MAF1 [cytosol]
(R-HSA-8944455)
MAF1 [cytosol]
(R-HSA-8944460)
MAF1 [nucleoplasm]
(R-HSA-8944422)
0.581
4
UniProt:P30041 PRDX6
3
PRDX6 [extracellular region]
(R-HSA-6806198)
PRDX6 [azurophil granule lumen]
(R-HSA-6798744)
PRDX6 [cytosol]
(R-HSA-3343670)
0.573
2
UniProt:P61769 B2M
11
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [plasma membrane]
(R-HSA-167743)
0.573
3
UniProt:P68104 EEF1A1
7
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
0.573
2
UniProt:P00558 PGK1
1
PGK1 [cytosol]
(R-HSA-70483)
0.573
2
UniProt:P07355 ANXA2
6
ANXA2 [cytosol]
(R-HSA-5263667)
ANXA2 [external side of plasma membrane]
(R-HSA-5336164)
p-Y24,S26-ANXA2 [cytosol]
(R-HSA-9865224)
p-S26-ANXA2 [cytosol]
(R-HSA-9865163)
ANXA2 [extracellular region]
(R-HSA-6806242)
ANXA2 [azurophil granule lumen]
(R-HSA-6798766)
0.573
2
UniProt:P04075 ALDOA
6
ALDOA [platelet alpha granule lumen]
(R-HSA-349738)
ALDOA [secretory granule lumen]
(R-HSA-6801469)
ALDOA [ficolin-1-rich granule lumen]
(R-HSA-6801521)
ALDOA [extracellular region]
(R-HSA-349735)
ALDOA [tertiary granule lumen]
(R-HSA-6801485)
ALDOA [cytosol]
(R-HSA-71492)
0.571
3
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.571
3
UniProt:P06733 ENO1
1
ENO1 [cytosol]
(R-HSA-71437)
0.571
3
UniProt:Q14527 HLTF
1
HLTF [nucleoplasm]
(R-HSA-8855007)
0.564
2
UniProt:P61970 NTF2
0.556
3
UniProt:Q9NZD8 SPG21
0.556
3
UniProt:Q96DZ9-2 CMTM5
0.556
3
UniProt:Q8IWU4 SLC30A8
2
SLC30A8 [Golgi membrane]
(R-HSA-9817561)
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.556
3
UniProt:P03129 VE7
0.547
2
UniProt:A8CG34 POM121C
1
POM121C [nuclear envelope]
(R-HSA-6805165)
0.547
2
UniProt:Q8IWL3 HSCB
5
HSCB [mitochondrial matrix]
(R-HSA-1299438)
HSCB(1-30) [mitochondrial matrix]
(R-HSA-8986120)
HSCB(1-235) [mitochondrial inner membrane]
(R-HSA-1299443)
HSCB [mitochondrial inner membrane]
(R-HSA-1299447)
HSCB(1-235) [mitochondrial intermembrane space]
(R-HSA-1299456)
0.547
2
UniProt:P18669 PGAM1
4
PGAM1 [secretory granule lumen]
(R-HSA-6803293)
PGAM1 [extracellular region]
(R-HSA-6806482)
PGAM1 [ficolin-1-rich granule lumen]
(R-HSA-6803309)
PGAM1 [cytosol]
(R-HSA-71442)
0.544
2
UniProt:Q9H160 ING2
2
monoSUMO1-K195-ING2 [nucleoplasm]
(R-HSA-4086075)
ING2 [nucleoplasm]
(R-HSA-3215167)
0.544
3
UniProt:P60174 TPI1
1
TPI1 [cytosol]
(R-HSA-70451)
0.544
2
UniProt:P03950 ANG
2
ANG [cytosol]
(R-HSA-9708345)
ANG [extracellular region]
(R-HSA-5692435)
0.537
4
UniProt:P35249 RFC4
1
RFC4 [nucleoplasm]
(R-HSA-68429)
0.527
2
UniProt:P24864 CCNE1
3
CCNE1 [nucleoplasm]
(R-HSA-68363)
CCNE1 [cytosol]
(R-HSA-157443)
Unfolded CCNE1 [cytosol]
(R-HSA-6813836)
0.527
3
UniProt:P35250 RFC2
1
RFC2 [nucleoplasm]
(R-HSA-68433)
0.527
2
UniProt:O96020 CCNE2
3
Unfolded CCNE2 [cytosol]
(R-HSA-6813844)
CCNE2 [cytosol]
(R-HSA-157452)
CCNE2 [nucleoplasm]
(R-HSA-68367)
0.527
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P52701 MSH6
2
MSH6 L222* [nucleoplasm]
(R-HSA-5632954)
MSH6 [nucleoplasm]
(R-HSA-5357528)
0.527
2
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.527
3
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.527
3
UniProt:Q9HCU8 POLD4
1
POLD4 [nucleoplasm]
(R-HSA-68447)
0.524
4
UniProt:B4URF7 B4URF7
0.508
2
UniProt:Q86TU7 SETD3
1
SETD3 [nucleoplasm]
(R-HSA-5688411)
0.508
3
UniProt:Q1K9H5 Q1K9H5
0.508
2
UniProt:Q9UBF6 RNF7
1
RNF7 (RBX2) [cytosol]
(R-HSA-8863132)
0.508
3
UniProt:Q8TE30 Q8TE30
0.499
6
UniProt:Q9H211 CDT1
1
CDT1 [nucleoplasm]
(R-HSA-68536)
0.499
2
UniProt:P57081 WDR4
1
WDR4 [nucleoplasm]
(R-HSA-6782341)
0.462
3
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