Reactome | RPA heterotrimer [nucleoplasm]

RPA heterotrimer [nucleoplasm]

Stable Identifier

R-HSA-68462

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

GO Cellular Component

DNA replication factor A complex (0005662)

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        ATR phosphorylates TP53 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Homo sapiens)
        
        RPA heterotrimer [nucleoplasm] (Homo sapiens)

Participants

components

Participates

as a component of

as an input of

as an output of

This entity regulates

Positively

HSF1 trimer binds HSE on the target gene (Homo sapiens)

Inferred To

RPA heterotrimer [nucleoplasm] (Bos taurus)

RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)

RPA heterotrimer [nucleoplasm] (Canis familiaris)

RPA heterotrimer [nucleoplasm] (Danio rerio)

RPA heterotrimer [nucleoplasm] (Dictyostelium discoideum)

RPA heterotrimer [nucleoplasm] (Drosophila melanogaster)

RPA heterotrimer [nucleoplasm] (Gallus gallus)

RPA heterotrimer [nucleoplasm] (Mus musculus)

RPA heterotrimer [nucleoplasm] (Plasmodium falciparum)

RPA heterotrimer [nucleoplasm] (Rattus norvegicus)

RPA heterotrimer [nucleoplasm] (Saccharomyces cerevisiae)

RPA heterotrimer [nucleoplasm] (Schizosaccharomyces pombe)

RPA heterotrimer [nucleoplasm] (Sus scrofa)

RPA heterotrimer [nucleoplasm] (Xenopus tropicalis)

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