Reactome | DNA2 [nucleoplasm]

DNA2 [nucleoplasm]

Stable Identifier

R-HSA-68465

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

dna2 endonuclease, DNA2-like homolog, DNA replication helicase-like homolog

Locations in the PathwayBrowser for interactor UniProt:Q6PGQ7 BORA

Expand all

External Reference Information

External Reference

UniProt:P51530 DNA2

Gene Names

DNA2, DNA2L, KIAA0083

Chain

chain:1-1060

Reference Genes

BioGPS Gene:1763 DNA2

COSMIC (genes):DNA2 DNA2

CTD Gene:1763 DNA2

dbSNP Gene:1763 DNA2

ENSEMBL:ENSG00000138346 DNA2

HGNC:2939 DNA2

KEGG:hsa:1763 DNA2

Monarch:1763 DNA2

NCBI Gene:1763 DNA2

OMIM:601810 DNA2

UCSC:P51530 DNA2

Reference Transcript

RefSeq:NM_001080449.2 DNA2

Other Identifiers

11752058_a_at

11755807_a_at

16714998

1763

213647_PM_at

213647_at

3292693

3292695

3292696

3292697

3292698

3292699

3292700

3292701

3292702

3292704

3292706

3292707

3292708

3292709

3292710

3292713

3292714

3292715

3292716

3292717

3292718

3292719

3292721

3292722

3292725

3292726

3292727

3292729

3292730

3292731

3292732

3461806

38885_at

7934026

A_24_P366107

A_33_P3833211

D42046_at

GE63205

GO:0000076

GO:0000723

GO:0000729

GO:0000781

GO:0003677

GO:0003678

GO:0003723

GO:0003824

GO:0004386

GO:0004518

GO:0004519

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005760

GO:0006259

GO:0006260

GO:0006264

GO:0006281

GO:0006284

GO:0016787

GO:0016887

GO:0016890

GO:0017108

GO:0017116

GO:0032200

GO:0032201

GO:0032508

GO:0033567

GO:0042645

GO:0043137

GO:0043139

GO:0043226

GO:0043504

GO:0044806

GO:0045740

GO:0046872

GO:0051539

GO:0071932

GO:0090304

GO:0090656

GO:0140097

GO:0140657

GO:1902990

HMNXSV003015016

Hs.194665.0.A1_3p_at

ILMN_1664682

ILMN_2282959

PH_hs_0011494

TC10001347.hg

TC10002686.hg

Participates

as an input of

as an output of

as a component of

Inferred To

dna-2 [nucleoplasm] (Caenorhabditis elegans)

DNA2 [nucleoplasm] (Bos taurus)

DNA2 [nucleoplasm] (Canis familiaris)

DNA2 [nucleoplasm] (Dictyostelium discoideum)

DNA2 [nucleoplasm] (Gallus gallus)

DNA2 [nucleoplasm] (Mus musculus)

DNA2 [nucleoplasm] (Rattus norvegicus)

DNA2 [nucleoplasm] (Saccharomyces cerevisiae)

DNA2 [nucleoplasm] (Schizosaccharomyces pombe)

DNA2 [nucleoplasm] (Sus scrofa)

Dna2 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of DNA2 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of DNA2 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001073918.2

ENSEMBL

ENST00000399179, ENSP00000351185, ENST00000358410, ENSP00000382132

OpenTargets

ENSG00000138346

HPA

ENSG00000138346-DNA2

PRO

P51530

Pharos - Targets

P51530

Orphanet

DNA2

HMDB Protein

HMDBP11710

PDB

5EAY

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99615 DNAJC7	2	DNAJC7 [nucleoplasm] (R-HSA-5255408) DNAJC7 [cytosol] (R-HSA-5252099)	0.527	2
UniProt:Q96T76 MMS19	1	MMS19 [cytosol] (R-HSA-2161121)	0.527	4
UniProt:Q641Q2 WAC2A			0.527	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.527	2
UniProt:O76071 CIAO1	1	CIAO1 [cytosol] (R-HSA-2161126)	0.527	4
UniProt:Q6PGQ7 BORA	3	BORA [cytosol] (R-HSA-2562607) p-S252,S497,T501-BORA [cytosol] (R-HSA-3000330) p-S252-BORA [cytosol] (R-HSA-4086411)	0.527	2
UniProt:O43683 BUB1	1	BUB1 [cytosol] (R-HSA-377888)	0.527	2
UniProt:Q9UHY1 NRBP1	1	NRBP1 [nucleoplasm] (R-HSA-376332)	0.527	4
UniProt:Q9UKA4 AKA11			0.527	2
UniProt:Q01850 CDR2			0.527	2
UniProt:Q9ULX3 NOB1	2	NOB1 [nucleoplasm] (R-HSA-6791536) NOB1 [cytosol] (R-HSA-6791524)	0.527	3