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What is Reactome ?
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ORC3 [nucleoplasm]
Stable Identifier
R-HSA-68513
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Orc3, Origin recognition complex subunit 3, Origin recognition complex subunit Latheo
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
E2F-enabled inhibition of pre-replication complex formation (Homo sapiens)
Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)
Cyclin B:CDK1:ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Assembly of the ORC complex at the origin of replication (Homo sapiens)
Formation of ORC(1-5) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Formation of ORC(1-6) complex (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Formation of ORC(2-5) complex (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC2 binds ORC3 (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC5 binds ORC2:ORC3 (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
CDC6 association with the ORC:origin complex (Homo sapiens)
CDC6 association with ORC(1-6) at replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-6):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5):origin of replication [nucleoplasm] (Homo sapiens)
ORC(1-5) [nucleoplasm] (Homo sapiens)
ORC(2-5) [nucleoplasm] (Homo sapiens)
ORC2:ORC3:ORC5 [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBD5 ORC3
Gene Names
ORC3, LATHEO, ORC3L
Chain
chain:1-711
Reference Genes
BioGPS Gene:23595 ORC3
COSMIC (genes):ORC3 ORC3
CTD Gene:23595 ORC3
dbSNP Gene:23595 ORC3
ENSEMBL:ENSG00000135336 ORC3
HGNC:8489 ORC3
KEGG:hsa:23595 ORC3
Monarch:23595 ORC3
NCBI Gene:23595 ORC3
OMIM:604972 ORC3
UCSC:Q9UBD5 ORC3
Reference Transcript
RefSeq:NM_001197259.1 ORC3
RefSeq:NM_181837.2 ORC3
RefSeq:NM_012381.3 ORC3
Other Identifiers
11718488_a_at
11718489_s_at
11747394_a_at
11748588_a_at
11749156_x_at
11750765_a_at
11761315_at
17010876
210028_PM_s_at
210028_s_at
23595
2916391
2916393
2916394
2916396
2916399
2916400
2916402
2916403
2916404
2916407
2916408
2916410
2916411
2916412
2916413
2916415
2916416
2916422
2916424
2916425
2916426
2916427
2916428
2916429
2916430
2916433
2916434
2916436
2916437
2916438
2916443
3342038
3342046
3342048
36895_at
8121043
87122_s_at
87124_f_at
A_23_P42045
GE61033
GO:0000781
GO:0000785
GO:0000808
GO:0003677
GO:0003688
GO:0005515
GO:0005634
GO:0005654
GO:0005656
GO:0005664
GO:0005694
GO:0006260
GO:0006270
GO:0006275
GO:0014009
GO:0016604
GO:0031261
GO:0043226
GO:0061351
HMNXSV003032340
HMNXSV003034498
ILMN_1784946
PH_hs_0023732
TC06000789.hg
U50950_at
g4337055_3p_a_at
p14607
Participates
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
ORC2:ORC3 [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
as an input of
ORC2 binds ORC3 (Homo sapiens)
Inferred To
ORC3 [nucleoplasm]
(Bos taurus)
ORC3 [nucleoplasm]
(Canis familiaris)
ORC3 [nucleoplasm]
(Gallus gallus)
ORC3 [nucleoplasm]
(Saccharomyces cerevisiae)
ORC3 [nucleoplasm]
(Sus scrofa)
orcC [nucleoplasm]
(Dictyostelium discoideum)
Orc3 [nucleoplasm]
(Drosophila melanogaster)
Orc3 [nucleoplasm]
(Mus musculus)
Orc3 [nucleoplasm]
(Rattus norvegicus)
orc3 [nucleoplasm]
(Schizosaccharomyces pombe)
orc3 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of ORC3 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_862820.1
,
NP_036513.2
,
NP_001184188.1
OpenTargets
ENSG00000135336
ENSEMBL
ENSP00000444695
,
ENST00000392844
,
ENSP00000376586
,
ENSP00000257789
,
ENSG00000135336
,
ENST00000257789
,
ENST00000546266
HPA
ENSG00000135336-ORC3
GeneCards
ORC3
PRO
Q9UBD5
Pharos - Targets
Q9UBD5
PDB
5UJM
,
7JPQ
,
7JPS
,
8S0E
,
7JPP
,
8S0C
,
5UJ8
,
7JPO
,
8S0F
,
8S0D
,
7CTE
,
7CTG
,
7JPR
,
7CTF
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13415 ORC1
5
ORC1 [nucleoplasm]
(R-HSA-68522)
ORC1 [cytosol]
(R-HSA-113840)
p-S,T-ORC1 [nucleoplasm]
(R-HSA-68943)
PolyUb,p-S,T-ORC1 [nucleoplasm]
(R-HSA-9032189)
PolyUb,p-S,T-ORC1 [cytosol]
(R-HSA-9032195)
0.824
16
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.702
28
UniProt:Q9Y5N6 ORC6
4
ORC6 [nucleoplasm]
(R-HSA-68539)
ORC6 [cytosol]
(R-HSA-9734663)
p-T195-ORC6 [cytosol]
(R-HSA-9734682)
p-T195-ORC6 [nucleoplasm]
(R-HSA-9734715)
0.656
4
UniProt:O43929 ORC4
1
ORC4 [nucleoplasm]
(R-HSA-68519)
0.59
12
UniProt:O43913 ORC5
1
ORC5 [nucleoplasm]
(R-HSA-68516)
0.59
15
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.527
2
UniProt:Q9Y5W9 SNX11
0.527
2
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![ORC3 [nucleoplasm] icon](/icon/R-ICO-013134.svg){kind=icon}
