Reactome | ORC6 [nucleoplasm]

ORC6 [nucleoplasm]

Stable Identifier

R-HSA-68539

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Orc6, Origin recognition complex subunit 6

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        Orc1 removal from chromatin (Homo sapiens)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
        
        ORC6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5N6 ORC6

Gene Names

ORC6, ORC6L

Chain

chain:1-252

Reference Genes

BioGPS Gene:23594 ORC6

COSMIC (genes):ORC6 ORC6

CTD Gene:23594 ORC6

dbSNP Gene:23594 ORC6

ENSEMBL:ENSG00000091651.9 ORC6

HGNC:17151 ORC6

KEGG Gene (Homo sapiens):23594 ORC6

Monarch:23594 ORC6

NCBI Gene:23594 ORC6

OMIM:607213 ORC6

UCSC:Q9Y5N6 ORC6

Reference Transcript

RefSeq:NM_014321.3 ORC6

Other Identifiers

11727837_at

16818600

219105_PM_x_at

219105_x_at

23594

3658927

3658932

3658933

3658934

3658938

3658939

3658941

3658943

3658944

3658945

3658946

53245_r_at

54827_at

54828_f_at

7995354

A_14_P122723

A_23_P100341

A_23_P100344

GE58580

GO:0000228

GO:0000808

GO:0001650

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005730

GO:0005829

GO:0006260

GO:0006270

GO:0016020

GO:0043226

GO:0051782

HMNXSV003005698

ILMN_2215061

PH_hs_0003454

TC16000425.hg

TC16001530.hg

g7657426_3p_at

Participates

as a component of

pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

ORC6 [cytosol]

p-T195-ORC6 [cytosol]

p-T195-ORC6 [nucleoplasm]

Inferred To

ORC6 [nucleoplasm] (Bos taurus)

ORC6 [nucleoplasm] (Canis familiaris)

ORC6 [nucleoplasm] (Gallus gallus)

ORC6 [nucleoplasm] (Sus scrofa)

Ghost homologue of ORC6 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of ORC6 [nucleoplasm] (Saccharomyces cerevisiae)

orc6 [nucleoplasm] (Schizosaccharomyces pombe)

orc6 [nucleoplasm] (Xenopus tropicalis)

Orc6 [nucleoplasm] (Drosophila melanogaster)

Orc6 [nucleoplasm] (Mus musculus)

Orc6 [nucleoplasm] (Rattus norvegicus)

orc6l [nucleoplasm] (Danio rerio)

orcF [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_055136.1

OpenTargets

ENSG00000091651

GeneCards

Q9Y5N6

HPA

ENSG00000091651-ORC6

Ensembl

ENST00000219097, ENSP00000219097, ENSG00000091651

PRO

Q9Y5N6

Pharos - Targets

Q9Y5N6

Orphanet

19835

PDB

6KVG, 3M03

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q969G2 LHX4	1	LHX4 [nucleoplasm] (R-HSA-9010585)	0.781	8
UniProt:Q96R06 SPAG5			0.666	4
UniProt:Q9UBD5 ORC3	1	ORC3 [nucleoplasm] (R-HSA-68513)	0.656	4
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.607	2
UniProt:P17096 HMGA1	2	HMGA1 [cytosol] (R-HSA-3004619) HMGA1 [nucleoplasm] (R-HSA-3004623)	0.602	4
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.527	2