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MCM3 [nucleoplasm]
Stable Identifier
R-HSA-68546
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mcm3, DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, RLF beta subunit, P102 protein, P1-MCM3
Locations in the PathwayBrowser for interactor UniProt:O75164 KDM4A
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM3 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
MCM3 binds MCM5 (Homo sapiens)
MCM3 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25205 MCM3
Gene Names
MCM3
Chain
initiator methionine:, chain:2-808
Reference Genes
BioGPS Gene:4172 MCM3
COSMIC (genes):MCM3 MCM3
CTD Gene:4172 MCM3
dbSNP Gene:4172 MCM3
ENSEMBL:ENSG00000112118 MCM3
HGNC:6945 MCM3
KEGG:hsa:4172 MCM3
Monarch:4172 MCM3
NCBI Gene:4172 MCM3
OMIM:602693 MCM3
UCSC:P25205 MCM3
Reference Transcript
RefSeq:NM_001270472.1 MCM3
RefSeq:NM_002388.4 MCM3
Other Identifiers
11742996_a_at
11742997_x_at
11748174_x_at
11749478_a_at
17020019
201555_3p_at
201555_PM_at
201555_at
2957127
2957128
2957129
2957130
2957131
2957132
2957133
2957134
2957138
2957139
2957144
2957145
2957148
2957149
2957151
2957152
2957154
2957155
2957156
2957158
2957159
2957160
2957162
2957164
2957165
2957166
2957167
2957168
2957169
33252_at
4172
8127031
A_23_P7873
D38073_at
GE81149
GO:0000727
GO:0000781
GO:0003677
GO:0003697
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005658
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0006259
GO:0006260
GO:0006268
GO:0006270
GO:0006271
GO:0006281
GO:0006310
GO:0016020
GO:0016787
GO:0016887
GO:0017116
GO:0030174
GO:0032508
GO:0042555
GO:0043226
GO:0048471
GO:0071162
GO:0140097
GO:0140657
GO:1902975
HMNXSV003033288
ILMN_1806818
ILMN_2224143
PH_hs_0010635
TC06001799.hg
X62153_s_at
g6631094_3p_at
g6631094_3p_x_at
Participates
as an output of
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
as an input of
MCM3 binds MCM5 (Homo sapiens)
as a component of
MCM3:MCM5 [nucleoplasm] (Homo sapiens)
Inferred To
Mcm3 [nucleoplasm]
(Rattus norvegicus)
mcm-3 [nucleoplasm]
(Caenorhabditis elegans)
mcm3 [nucleoplasm]
(Dictyostelium discoideum)
mcm3l [nucleoplasm]
(Danio rerio)
MCM3 [nucleoplasm]
(Bos taurus)
MCM3 [nucleoplasm]
(Canis familiaris)
MCM3 [nucleoplasm]
(Drosophila melanogaster)
MCM3 [nucleoplasm]
(Gallus gallus)
MCM3 [nucleoplasm]
(Mus musculus)
MCM3 [nucleoplasm]
(Plasmodium falciparum)
MCM3 [nucleoplasm]
(Saccharomyces cerevisiae)
MCM3 [nucleoplasm]
(Schizosaccharomyces pombe)
MCM3 [nucleoplasm]
(Sus scrofa)
MCM3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001257401.1
,
NP_002379.3
OpenTargets
ENSG00000112118
ENSEMBL
ENSG00000112118
,
ENST00000616552
,
ENST00000596288
,
ENSP00000472940
,
ENSP00000480987
IntEnz
3.6.4.12
HPA
ENSG00000112118-MCM3
GeneCards
MCM3
PRO
P25205
Pharos - Targets
P25205
GlyGen
P25205
HMDB Protein
HMDBP11817
PDB
6XTY
,
8S09
,
6XTX
,
7W1Y
,
8S0A
,
7PFO
,
7W68
,
8B9D
,
7PLO
,
8S0E
,
8S0B
,
8S0F
,
8S0D
,
8W0E
,
8W0G
,
8W0I
,
8W0F
,
9CAQ
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.924
9
UniProt:Q9BTE3 MCMBP
0.886
13
UniProt:P33992 MCM5
1
MCM5 [nucleoplasm]
(R-HSA-68551)
0.845
8
UniProt:Q14566 MCM6
1
MCM6 [nucleoplasm]
(R-HSA-68553)
0.813
5
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.758
13
UniProt:Q99598 TSNAX
1
TSNAX [cytosol]
(R-HSA-5216130)
0.527
2
UniProt:P33991 MCM4
1
MCM4 [nucleoplasm]
(R-HSA-68549)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9GZM5 YIPF3
0.527
2
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.499
2
UniProt:Q13416 ORC2
1
ORC2 [nucleoplasm]
(R-HSA-68405)
0.499
2
UniProt:O75164 KDM4A
2
KDM4A [nucleoplasm]
(R-HSA-351646)
K48PolyUb-KDM4A [nucleoplasm]
(R-HSA-5683049)
0.462
3
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