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MCM4 [nucleoplasm]
Stable Identifier
R-HSA-68549
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mcm4, DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
p-MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
MCM2-7 mediated fork unwinding (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Multiple proteins are localized at replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Mcm2-7 is phosphorylated by DDK (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
p-MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
ATP-dependent release of CDT1 from the OCCM complex (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
CDT1 binds MCM2-7 (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
CDT1-mediated formation of MCM2-7 double hexamer at the replication origin (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin or replication:MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
MCM2-7 double hexamer [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
CDT1-mediated loading of MCM2-7 to replication origins (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
ORC(1-6):CDC6:origin of replication:CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
CDT1:MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Formation of MCM2-7 complex (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Unwinding of DNA (Homo sapiens)
MCM2-7 mediated fork unwinding (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Multiple proteins are localized at replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM2-7 [nucleoplasm] (Homo sapiens)
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
MCM4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33991 MCM4
Gene Names
MCM4, CDC21
Chain
initiator methionine:, chain:2-863
Reference Genes
BioGPS Gene:4173 MCM4
COSMIC (genes):MCM4 MCM4
CTD Gene:4173 MCM4
dbSNP Gene:4173 MCM4
ENSEMBL:ENSG00000104738 MCM4
HGNC:6947 MCM4
KEGG:hsa:4173 MCM4
Monarch:4173 MCM4
NCBI Gene:4173 MCM4
OMIM:602638 MCM4
UCSC:P33991 MCM4
Reference Transcript
RefSeq:NM_182746.2 MCM4
RefSeq:NM_005914.3 MCM4
Other Identifiers
11736670_a_at
11743692_a_at
11743693_a_at
11759509_s_at
11759510_x_at
17068782
17068812
212141_PM_at
212141_at
212142_PM_at
212142_at
222036_PM_s_at
222036_s_at
222037_PM_at
222037_at
242479_PM_s_at
242479_s_at
3097154
3097155
3097156
3097157
3097158
3097159
3097160
3097161
3097162
3097163
3097164
3097165
3097166
3097167
3097168
3097169
3097170
3097171
3097172
3097173
3097175
3097176
3097177
3097178
3097179
3097180
3097181
3097182
3097183
3097184
3097185
3097186
3097187
3097188
3097189
3097190
3097191
3097192
3097193
3097194
3097195
3097196
3097197
3097198
3097199
3097200
3097201
3097202
3097203
3097205
4173
42875_r_at
52597_at
63855_r_at
8146357
8146377
981_at
A_14_P102189
A_14_P118280
A_14_P118623
A_14_P134350
A_23_P370989
GO:0000727
GO:0000781
GO:0003677
GO:0003678
GO:0003697
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0006139
GO:0006259
GO:0006260
GO:0006268
GO:0006270
GO:0006271
GO:0006281
GO:0006310
GO:0016020
GO:0016787
GO:0016887
GO:0017116
GO:0030174
GO:0032508
GO:0042555
GO:0043226
GO:0071162
GO:0140097
GO:0140657
GO:1902975
HMNXSV003008366
Hs.154443.0.S1_3p_at
Hs.154443.0.S2_3p_at
Hs.154443.1.S1_3p_a_at
Hs.154443.1.S1_3p_x_at
Hs.296277.0.S1_3p_s_at
ILMN_1737205
ILMN_2412860
PH_hs_0026403
TC08000346.hg
TC08000347.hg
X74794_at
Participates
as an input of
MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)
as a component of
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Inferred To
mcm4 [nucleoplasm]
(Danio rerio)
mcm4 [nucleoplasm]
(Dictyostelium discoideum)
Mcm4 [nucleoplasm]
(Rattus norvegicus)
MCM4 [nucleoplasm]
(Bos taurus)
MCM4 [nucleoplasm]
(Caenorhabditis elegans)
MCM4 [nucleoplasm]
(Canis familiaris)
MCM4 [nucleoplasm]
(Drosophila melanogaster)
MCM4 [nucleoplasm]
(Gallus gallus)
MCM4 [nucleoplasm]
(Mus musculus)
MCM4 [nucleoplasm]
(Plasmodium falciparum)
MCM4 [nucleoplasm]
(Saccharomyces cerevisiae)
MCM4 [nucleoplasm]
(Schizosaccharomyces pombe)
MCM4 [nucleoplasm]
(Sus scrofa)
MCM4 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005905.2
,
NP_877423.1
OpenTargets
ENSG00000104738
ENSEMBL
ENSP00000262105
,
ENST00000649973
,
ENST00000262105
,
ENSP00000496964
HPA
ENSG00000104738-MCM4
PRO
P33991
Pharos - Targets
P33991
Orphanet
MCM4
GlyGen
P33991
PDB
6XTX
,
6XTY
,
8B9D
,
7PLO
,
7W1Y
,
7PFO
,
7W68
HMDB Protein
HMDBP11818
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.924
15
UniProt:Q9BTE3 MCMBP
0.851
14
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.83
9
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.816
8
UniProt:Q14566 MCM6
1
MCM6 [nucleoplasm]
(R-HSA-68553)
0.771
6
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.602
3
UniProt:Q9Q2G4 Q9Q2G4
0.558
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.527
4
UniProt:Q93009 USP7
2
USP7 [nucleoplasm]
(R-HSA-3215278)
USP7 [cytosol]
(R-HSA-8853511)
0.527
2
UniProt:P62805 H4C1
17
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
HIST1H4A [extracellular region]
(R-HSA-977569)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
0.527
3
UniProt:Q13451 FKBP5
2
FKBP5 [nucleoplasm]
(R-HSA-8939165)
FKBP5 [cytosol]
(R-HSA-5618096)
0.527
2
UniProt:P25205 MCM3
1
MCM3 [nucleoplasm]
(R-HSA-68546)
0.527
2
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
4
UniProt:Q9NVP2 ASF1B
0.527
3
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.527
3
UniProt:P53350 PLK1
4
PLK1 [cytosol]
(R-HSA-164603)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [nucleoplasm]
(R-HSA-156720)
0.508
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
9
UniProt:P03366 POL
0.462
2
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