Reactome | MCM4 [nucleoplasm]

MCM4 [nucleoplasm]

Stable Identifier

R-HSA-68549

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mcm4, DNA replication licensing factor MCM4, CDC21 homolog, P1-CDC21

Locations in the PathwayBrowser for interactor UniProt:Q9Q2G4 Q9Q2G4

Expand all

External Reference Information

External Reference

UniProt:P33991 MCM4

Gene Names

MCM4, CDC21

Chain

initiator methionine:, chain:2-863

Reference Genes

BioGPS Gene:4173 MCM4

COSMIC (genes):MCM4 MCM4

CTD Gene:4173 MCM4

dbSNP Gene:4173 MCM4

ENSEMBL:ENSG00000104738 MCM4

HGNC:6947 MCM4

KEGG:hsa:4173 MCM4

Monarch:4173 MCM4

NCBI Gene:4173 MCM4

OMIM:602638 MCM4

UCSC:P33991 MCM4

Reference Transcript

Other Identifiers

11736670_a_at

11743692_a_at

11743693_a_at

11759509_s_at

11759510_x_at

17068782

17068812

212141_PM_at

212141_at

212142_PM_at

212142_at

222036_PM_s_at

222036_s_at

222037_PM_at

222037_at

242479_PM_s_at

242479_s_at

3097154

3097155

3097156

3097157

3097158

3097159

3097160

3097161

3097162

3097163

3097164

3097165

3097166

3097167

3097168

3097169

3097170

3097171

3097172

3097173

3097175

3097176

3097177

3097178

3097179

3097180

3097181

3097182

3097183

3097184

3097185

3097186

3097187

3097188

3097189

3097190

3097191

3097192

3097193

3097194

3097195

3097196

3097197

3097198

3097199

3097200

3097201

3097202

3097203

3097205

4173

42875_r_at

52597_at

63855_r_at

8146357

8146377

981_at

A_14_P102189

A_14_P118280

A_14_P118623

A_14_P134350

A_23_P370989

GO:0000727

GO:0000781

GO:0003677

GO:0003678

GO:0003697

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0006139

GO:0006259

GO:0006260

GO:0006268

GO:0006270

GO:0006271

GO:0006281

GO:0006310

GO:0016020

GO:0016787

GO:0016887

GO:0017116

GO:0030174

GO:0032508

GO:0042555

GO:0043226

GO:0071162

GO:0140097

GO:0140657

GO:1902975

HMNXSV003008366

Hs.154443.0.S1_3p_at

Hs.154443.0.S2_3p_at

Hs.154443.1.S1_3p_a_at

Hs.154443.1.S1_3p_x_at

Hs.296277.0.S1_3p_s_at

ILMN_1737205

ILMN_2412860

PH_hs_0026403

TC08000346.hg

TC08000347.hg

X74794_at

Participates

as an input of

MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)

as a component of

MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)

Inferred To

mcm4 [nucleoplasm] (Danio rerio)

mcm4 [nucleoplasm] (Dictyostelium discoideum)

Mcm4 [nucleoplasm] (Rattus norvegicus)

MCM4 [nucleoplasm] (Bos taurus)

MCM4 [nucleoplasm] (Caenorhabditis elegans)

MCM4 [nucleoplasm] (Canis familiaris)

MCM4 [nucleoplasm] (Drosophila melanogaster)

MCM4 [nucleoplasm] (Gallus gallus)

MCM4 [nucleoplasm] (Mus musculus)

MCM4 [nucleoplasm] (Plasmodium falciparum)

MCM4 [nucleoplasm] (Saccharomyces cerevisiae)

MCM4 [nucleoplasm] (Schizosaccharomyces pombe)

MCM4 [nucleoplasm] (Sus scrofa)

MCM4 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_005905.2, NP_877423.1

OpenTargets

ENSG00000104738

ENSEMBL

ENSP00000262105, ENST00000649973, ENST00000262105, ENSP00000496964

HPA

ENSG00000104738-MCM4

PRO

P33991

Pharos - Targets

P33991

Orphanet

MCM4

GlyGen

P33991

PDB

6XTX, 6XTY, 8B9D, 7PLO, 7W1Y, 7PFO, 7W68

HMDB Protein

HMDBP11818

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.924	15
UniProt:Q9BTE3 MCMBP			0.851	14
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.83	9
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.816	8
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.771	6
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.602	3
UniProt:Q9Q2G4 Q9Q2G4			0.558	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	4
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.527	2
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.527	3
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.527	2
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	4
UniProt:Q9NVP2 ASF1B			0.527	3
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.527	3
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9
UniProt:P03366 POL			0.462	2

Cite Us!