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MCM7 [nucleoplasm]
Stable Identifier
R-HSA-68555
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mcm7, DNA replication licensing factor MCM7, CDC47 homolog, P1.1-MCM3
Locations in the PathwayBrowser for interactor UniProt:Q96QK1 VPS35
Expand all
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)
MCM7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P33993 MCM7
Gene Names
MCM7, CDC47, MCM2
Chain
initiator methionine:, chain:2-719
Reference Genes
BioGPS Gene:4176 MCM7
COSMIC (genes):MCM7 MCM7
CTD Gene:4176 MCM7
dbSNP Gene:4176 MCM7
ENSEMBL:ENSG00000166508 MCM7
ENSEMBL_homo_sapiens_GENE:ENSG00000166508.19 MCM7
HGNC:6950 MCM7
KEGG Gene (Homo sapiens):4176 MCM7
Monarch:4176 MCM7
NCBI Gene:4176 MCM7
OMIM:600592 MCM7
UCSC:P33993 MCM7
Reference Transcript
RefSeq:NM_182776.2 MCM7
RefSeq:NM_005916.4 MCM7
RefSeq:NM_001278595.1 MCM7
Other Identifiers
11729603_a_at
11752905_a_at
11753558_x_at
11755469_x_at
17060412
208795_PM_s_at
208795_s_at
210983_PM_s_at
210983_s_at
3063686
3063687
3063688
3063689
3063690
3063696
3063697
3063699
3063700
3063701
3063702
3063703
3063704
3063705
3063708
3063709
3063710
3063711
3063712
3063714
3063715
3063717
3063718
3063719
3063721
3063725
3063726
4176
8141395
947_at
A_23_P93690
A_33_P3258223
D55716_at
GE57265
GO:0000166
GO:0000228
GO:0000727
GO:0000781
GO:0000785
GO:0003677
GO:0003678
GO:0003697
GO:0003824
GO:0004386
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006259
GO:0006260
GO:0006268
GO:0006270
GO:0006271
GO:0006281
GO:0006310
GO:0006974
GO:0007049
GO:0008283
GO:0016020
GO:0016787
GO:0016887
GO:0017116
GO:0030174
GO:0032508
GO:0042325
GO:0042555
GO:0043226
GO:0043229
GO:0071162
GO:0071466
GO:0140097
GO:0140657
HMNXSV003041394
ILMN_1663195
ILMN_1704702
PH_hs_0020775
TC07001654.hg
g1255616_3p_a_at
g12751125_3p_a_at
Participates
as an input of
MCM4, MCM6 and MCM7 form a heterotrimer (Homo sapiens)
as a component of
MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Inferred To
mcm7 [nucleoplasm]
(Danio rerio)
mcm-7 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of MCM7 [nucleoplasm]
(Gallus gallus)
MCM7 [nucleoplasm]
(Bos taurus)
MCM7 [nucleoplasm]
(Canis familiaris)
MCM7 [nucleoplasm]
(Dictyostelium discoideum)
MCM7 [nucleoplasm]
(Drosophila melanogaster)
MCM7 [nucleoplasm]
(Mus musculus)
MCM7 [nucleoplasm]
(Plasmodium falciparum)
MCM7 [nucleoplasm]
(Rattus norvegicus)
MCM7 [nucleoplasm]
(Saccharomyces cerevisiae)
MCM7 [nucleoplasm]
(Schizosaccharomyces pombe)
MCM7 [nucleoplasm]
(Sus scrofa)
MCM7 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001265524.1
,
NP_877577.1
,
NP_005907.3
OpenTargets
ENSG00000166508
GeneCards
P33993
HPA
ENSG00000166508-MCM7
Ensembl
ENST00000303887
,
ENSP00000307288
,
ENSG00000166508
,
ENSP00000344006
,
ENST00000343023
PRO
P33993
Pharos - Targets
P33993
HMDB Protein
HMDBP10786
PDB
6XTX
,
8B9D
,
7PFO
,
7W1Y
,
7PLO
,
6XTY
,
7W68
Interactors (55)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.931
24
UniProt:P33991 MCM4
1
MCM4 [nucleoplasm]
(R-HSA-68549)
0.924
15
UniProt:Q9BTE3 MCMBP
0.9
21
UniProt:Q14566 MCM6
1
MCM6 [nucleoplasm]
(R-HSA-68553)
0.823
7
UniProt:P25205 MCM3
1
MCM3 [nucleoplasm]
(R-HSA-68546)
0.758
13
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.731
7
UniProt:Q9BTE3-2 MCMBP
0.718
6
UniProt:P33992 MCM5
1
MCM5 [nucleoplasm]
(R-HSA-68551)
0.688
10
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.669
3
UniProt:P03126 VE6
0.667
3
UniProt:Q96MA6 AK8
1
AK8 [cytosol]
(R-HSA-6788788)
0.666
4
UniProt:Q14683 SMC1A
4
SMC1A [cytosol]
(R-HSA-2484798)
SMC1A [chromosome]
(R-HSA-1638774)
SMC1A [chromosome, centromeric region]
(R-HSA-2466015)
SMC1A [nucleoplasm]
(R-HSA-64561)
0.645
8
UniProt:Q9UL03 INTS6
1
INTS6 [nucleoplasm]
(R-HSA-6807440)
0.625
10
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
20
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.609
2
UniProt:P04019 VE6
0.592
2
UniProt:P07948-1 LYN
0.591
5
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.564
2
UniProt:Q8ND90 PNMA1
0.556
3
UniProt:Q68D86 C102B
0.556
3
UniProt:Q9UMX0-2 UBQLN1
0.556
3
UniProt:Q8TD10 MIPO1
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:Q9NS73-5 MBIP
0.556
3
UniProt:Q9BVG8 KIFC3
0.556
3
UniProt:Q9BYV2 TRI54
0.556
3
UniProt:Q02086 SP2
0.556
3
IntAct:EBI-10206361 116328
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.527
3
UniProt:Q9BRT9 GINS4
1
GINS4 [nucleoplasm]
(R-HSA-176963)
0.527
3
UniProt:Q9Y248 GINS2
1
GINS2 [nucleoplasm]
(R-HSA-176975)
0.527
3
UniProt:Q96QK1 VPS35
1
VPS35 [cytosol]
(R-HSA-3247740)
0.527
3
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.527
3
UniProt:P06462 VE6
0.527
2
UniProt:Q14691 GINS1
1
GINS1 [nucleoplasm]
(R-HSA-176955)
0.527
3
UniProt:P06463 VE6
0.527
2
UniProt:O75436 VPS26A
1
VPS26A [cytosol]
(R-HSA-3247739)
0.527
3
UniProt:Q9BVW5 TIPIN
1
TIPIN [nucleoplasm]
(R-HSA-5684983)
0.527
2
UniProt:Q96A08 H2BC1
9
HIST1H2BA [nucleoplasm]
(R-HSA-181916)
Ub-122-HIST1H2BA [nucleoplasm]
(R-HSA-3364020)
AcK22-HIST1H2BA [nucleoplasm]
(R-HSA-4568647)
AcK17-HIST1H2BA [nucleoplasm]
(R-HSA-4568631)
AcK14-HIST1H2BA [nucleoplasm]
(R-HSA-4568615)
AcK7-HIST1H2BA [nucleoplasm]
(R-HSA-4568624)
HIST1H2BA [extracellular region]
(R-HSA-977582)
AcK-HIST1H2BA [nucleoplasm]
(R-HSA-4549263)
Ub-HIST1H2BA [nucleoplasm]
(R-HSA-6782561)
0.527
4
UniProt:Q9Y468 L3MBTL1
1
L3MBTL1 [nucleoplasm]
(R-HSA-3222110)
0.527
2
UniProt:Q9BRX5 GINS3
1
GINS3 [nucleoplasm]
(R-HSA-5688046)
0.527
3
UniProt:Q9NVP2 ASF1B
0.527
3
UniProt:O15078 CEP290
3
CEP290 [extracellular region]
(R-HSA-6806291)
CEP290 [specific granule lumen]
(R-HSA-6799524)
CEP290 [cytosol]
(R-HSA-380275)
0.527
2
UniProt:P49918 CDKN1C
3
p-Y91-CDKN1C [cytosol]
(R-HSA-8942606)
CDKN1C [cytosol]
(R-HSA-8941913)
CDKN1C [nucleoplasm]
(R-HSA-8948130)
0.527
2
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.527
2
UniProt:Q9UBN7 HDAC6
4
HDAC6 [nucleoplasm]
(R-HSA-351589)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
0.527
3
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.527
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.524
4
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
LYN [cytosol]
(R-HSA-354251)
0.499
4
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
UniProt:P03366 POL
0.462
2
UniProt:O75164 KDM4A
2
K48PolyUb-KDM4A [nucleoplasm]
(R-HSA-5683049)
KDM4A [nucleoplasm]
(R-HSA-351646)
0.462
3
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