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MCM2 [nucleoplasm]
Stable Identifier
R-HSA-68557
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Mcm2, DNA replication licensing factor MCM2, Nuclear protein BM28
Locations in the PathwayBrowser for interactor UniProt:P25205 MCM3
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
MCM2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49736 MCM2
Gene Names
MCM2, BM28, CCNL1, CDCL1, KIAA0030
Chain
initiator methionine:1, chain:2-904
Reference Genes
BioGPS Gene:4171 MCM2
COSMIC (genes):MCM2 MCM2
CTD Gene:4171 MCM2
dbSNP Gene:4171 MCM2
ENSEMBL:ENSG00000073111 MCM2
HGNC:6944 MCM2
KEGG Gene (Homo sapiens):4171 MCM2
Monarch:4171 MCM2
NCBI Gene:4171 MCM2
OMIM:116945 MCM2
UCSC:P49736 MCM2
Reference Transcript
RefSeq:NM_004526.3 MCM2
Other Identifiers
0002120121
11715991_a_at
11715992_s_at
11746594_a_at
11756666_x_at
16945101
202107_PM_s_at
202107_s_at
2640859
2640862
2640863
2640864
2640865
2640866
2640867
2640868
2640869
2640870
2640873
2640874
2640875
2640877
2640878
2640879
2640881
2640882
2640883
2640884
2640885
35312_at
4171
8082350
A_32_P103633
D21063_at
GE57107
GO:0000166
GO:0000228
GO:0000278
GO:0000727
GO:0000781
GO:0000785
GO:0003674
GO:0003677
GO:0003678
GO:0003688
GO:0003697
GO:0004386
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005664
GO:0005694
GO:0005737
GO:0006259
GO:0006260
GO:0006268
GO:0006270
GO:0006334
GO:0006915
GO:0006950
GO:0007049
GO:0008150
GO:0008219
GO:0009058
GO:0016787
GO:0016887
GO:0017116
GO:0019899
GO:0022607
GO:0030174
GO:0032508
GO:0032991
GO:0034641
GO:0042393
GO:0042555
GO:0043138
GO:0043167
GO:0043226
GO:0046872
GO:0048856
GO:0051276
GO:0065003
GO:0071162
GO:0071353
GO:0090102
GO:0140657
GO:1902975
GO:1905775
HMNXSV003042467
ILMN_1681503
PH_hs_0003681
TC03000664.hg
g4758705_3p_s_at
Participates
as an output of
Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
as an input of
MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)
as a component of
MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)
Inferred To
mcm-2 [nucleoplasm]
(Caenorhabditis elegans)
Mcm2 [nucleoplasm]
(Drosophila melanogaster)
Mcm2 [nucleoplasm]
(Mus musculus)
Mcm2 [nucleoplasm]
(Rattus norvegicus)
mcm2 [nucleoplasm]
(Danio rerio)
mcm2 [nucleoplasm]
(Schizosaccharomyces pombe)
mcm2 [nucleoplasm]
(Xenopus tropicalis)
MCM2 [nucleoplasm]
(Bos taurus)
MCM2 [nucleoplasm]
(Canis familiaris)
MCM2 [nucleoplasm]
(Dictyostelium discoideum)
MCM2 [nucleoplasm]
(Gallus gallus)
MCM2 [nucleoplasm]
(Plasmodium falciparum)
MCM2 [nucleoplasm]
(Saccharomyces cerevisiae)
MCM2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_004517.2
OpenTargets
ENSG00000073111
GeneCards
P49736
HPA
ENSG00000073111-MCM2
Ensembl
ENSP00000265056
,
ENST00000265056
,
ENSG00000073111
PRO
P49736
Pharos - Targets
P49736
Orphanet
23776
HMDB Protein
HMDBP11816
PDB
6XTX
,
5JA4
,
7CJ0
,
5BO0
,
5BNV
,
6YA7
,
5BNX
,
6XTY
,
4UUZ
,
7CIZ
,
5C3I
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14566 MCM6
1
MCM6 [nucleoplasm]
(R-HSA-68553)
0.947
17
UniProt:P25205 MCM3
1
MCM3 [nucleoplasm]
(R-HSA-68546)
0.916
8
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.903
22
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.855
10
UniProt:P33992 MCM5
1
MCM5 [nucleoplasm]
(R-HSA-68551)
0.8
5
UniProt:P33991 MCM4
1
MCM4 [nucleoplasm]
(R-HSA-68549)
0.78
7
UniProt:P62805 H4C1
17
HIST1H4A [extracellular region]
(R-HSA-977569)
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
0.748
9
UniProt:Q9BTE3 MCMBP
0.723
4
UniProt:Q9NVP2 ASF1B
0.708
4
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.669
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.657
3
UniProt:Q96H20 SNF8
1
SNF8 [cytosol]
(R-HSA-917711)
0.633
8
UniProt:P68431 H3C1
20
HIST1H3A [extracellular region]
(R-HSA-977570)
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
AcK19-HIST1H3A [nucleoplasm]
(R-HSA-4568761)
AcK5-HIST1H3A [nucleoplasm]
(R-HSA-4568751)
AcK24-HIST1H3A [nucleoplasm]
(R-HSA-4568754)
Ack15-HIST1H3A [nucleoplasm]
(R-HSA-4549217)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
0.623
6
UniProt:O43823 AKAP8
0.581
7
UniProt:Q71DI3 H3C15
20
HIST2H3A [extracellular region]
(R-HSA-977578)
2xAcK-HIST2H3A [nucleoplasm]
(R-HSA-427525)
AcK24-HIST2H3A [nucleoplasm]
(R-HSA-4568747)
AcK19-HIST2H3A [nucleoplasm]
(R-HSA-4568750)
AcK5-HIST2H3A [nucleoplasm]
(R-HSA-4568752)
Ack15-HIST2H3A [nucleoplasm]
(R-HSA-4549224)
Me2aR27-HIST2H3A [nucleoplasm]
(R-HSA-5229057)
Me2aR18-HIST2H3A [nucleoplasm]
(R-HSA-5229063)
Me2sR9-HIST2H3A [nucleoplasm]
(R-HSA-5211327)
Me2sR3-HIST2H3A [nucleoplasm]
(R-HSA-5218930)
AcK9,14-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8870892)
AcK14,18,79-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8871273)
AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871304)
AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871292)
AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8865607)
AcK14,18-p-S10-HIST2H3A [nucleoplasm]
(R-HSA-8871296)
AcK14,18,79-p-T11-HIST2H3A [nucleoplasm]
(R-HSA-8871290)
AcK14,18-p-T11-HIST2H3A [nucleoplasm]
(R-HSA-8871302)
AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm]
(R-HSA-8871289)
Me2K28-HIST2H3A [nucleoplasm]
(R-HSA-4754197)
0.576
5
UniProt:P49450 CENPA
2
CENPA [nucleoplasm]
(R-HSA-606322)
CENPA [cytosol]
(R-HSA-375317)
0.576
3
UniProt:O75419 CDC45
1
CDC45 [nucleoplasm]
(R-HSA-68563)
0.574
2
UniProt:P84243 H3-3A
15
H3F3A [extracellular region]
(R-HSA-977567)
MeK-H3F3A [nucleoplasm]
(R-HSA-427369)
2xAcK-H3F3A [nucleoplasm]
(R-HSA-427504)
Me2K5,Me2aR2-H3F3A [nucleoplasm]
(R-HSA-8936573)
AcK10-H3F3A [nucleoplasm]
(R-HSA-5250654)
p-T12-H3F3A [nucleoplasm]
(R-HSA-5625878)
p-T12,MeK-H3F3A [nucleoplasm]
(R-HSA-5625858)
p-T12, Me2K-10-H3F3A [nucleoplasm]
(R-HSA-5625800)
p-T12,Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625758)
Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625747)
Me2K-10-H3F3A [nucleoplasm]
(R-HSA-427324)
Me3K5-H3F3A [nucleoplasm]
(R-HSA-1214216)
Me3K-28-H3F3A [nucleoplasm]
(R-HSA-212282)
H3F3A [nucleoplasm]
(R-HSA-212295)
Me2K5-H3F3A [nucleoplasm]
(R-HSA-1214206)
0.544
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9NYB0 TERF2IP
1
TERF2IP [nucleoplasm]
(R-HSA-174873)
0.508
2
UniProt:Q9Y468 L3MBTL1
1
L3MBTL1 [nucleoplasm]
(R-HSA-3222110)
0.499
2
UniProt:P03433 PA
4
PA [extracellular region]
(R-FLU-169243)
PA [endosome lumen]
(R-FLU-189131)
PA [nucleoplasm]
(R-FLU-188877)
PA [cytosol]
(R-FLU-195948)
0.462
2
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