Reactome | MCM2 [nucleoplasm]

MCM2 [nucleoplasm]

Stable Identifier

R-HSA-68557

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mcm2, DNA replication licensing factor MCM2, Nuclear protein BM28

Locations in the PathwayBrowser for interactor UniProt:P25205 MCM3

Expand all

External Reference Information

External Reference

UniProt:P49736 MCM2

Gene Names

MCM2, BM28, CCNL1, CDCL1, KIAA0030

Chain

initiator methionine:1, chain:2-904

Reference Genes

BioGPS Gene:4171 MCM2

COSMIC (genes):MCM2 MCM2

CTD Gene:4171 MCM2

dbSNP Gene:4171 MCM2

ENSEMBL:ENSG00000073111 MCM2

HGNC:6944 MCM2

KEGG Gene (Homo sapiens):4171 MCM2

Monarch:4171 MCM2

NCBI Gene:4171 MCM2

OMIM:116945 MCM2

UCSC:P49736 MCM2

Reference Transcript

RefSeq:NM_004526.3 MCM2

Other Identifiers

0002120121

11715991_a_at

11715992_s_at

11746594_a_at

11756666_x_at

16945101

202107_PM_s_at

202107_s_at

2640859

2640862

2640863

2640864

2640865

2640866

2640867

2640868

2640869

2640870

2640873

2640874

2640875

2640877

2640878

2640879

2640881

2640882

2640883

2640884

2640885

35312_at

4171

8082350

A_32_P103633

D21063_at

GE57107

GO:0000166

GO:0000228

GO:0000278

GO:0000727

GO:0000781

GO:0000785

GO:0003674

GO:0003677

GO:0003678

GO:0003688

GO:0003697

GO:0004386

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005664

GO:0005694

GO:0005737

GO:0006259

GO:0006260

GO:0006268

GO:0006270

GO:0006334

GO:0006915

GO:0006950

GO:0007049

GO:0008150

GO:0008219

GO:0009058

GO:0016787

GO:0016887

GO:0017116

GO:0019899

GO:0022607

GO:0030174

GO:0032508

GO:0032991

GO:0034641

GO:0042393

GO:0042555

GO:0043138

GO:0043167

GO:0043226

GO:0046872

GO:0048856

GO:0051276

GO:0065003

GO:0071162

GO:0071353

GO:0090102

GO:0140657

GO:1902975

GO:1905775

HMNXSV003042467

ILMN_1681503

PH_hs_0003681

TC03000664.hg

g4758705_3p_s_at

Participates

as an output of

Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)

as an input of

MCM2 binds MCM4:MCM6:MCM7 heterotrimer (Homo sapiens)

as a component of

MCM2:MCM4:MCM6:MCM7 [nucleoplasm] (Homo sapiens)

Inferred To

mcm-2 [nucleoplasm] (Caenorhabditis elegans)

Mcm2 [nucleoplasm] (Drosophila melanogaster)

Mcm2 [nucleoplasm] (Mus musculus)

Mcm2 [nucleoplasm] (Rattus norvegicus)

mcm2 [nucleoplasm] (Danio rerio)

mcm2 [nucleoplasm] (Schizosaccharomyces pombe)

mcm2 [nucleoplasm] (Xenopus tropicalis)

MCM2 [nucleoplasm] (Bos taurus)

MCM2 [nucleoplasm] (Canis familiaris)

MCM2 [nucleoplasm] (Dictyostelium discoideum)

MCM2 [nucleoplasm] (Gallus gallus)

MCM2 [nucleoplasm] (Plasmodium falciparum)

MCM2 [nucleoplasm] (Saccharomyces cerevisiae)

MCM2 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_004517.2

OpenTargets

ENSG00000073111

GeneCards

P49736

HPA

ENSG00000073111-MCM2

Ensembl

ENSP00000265056, ENST00000265056, ENSG00000073111

PRO

P49736

Pharos - Targets

P49736

Orphanet

23776

HMDB Protein

HMDBP11816

PDB

6XTX, 5JA4, 7CJ0, 5BO0, 5BNV, 6YA7, 5BNX, 6XTY, 4UUZ, 7CIZ, 5C3I

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14566 MCM6	1	MCM6 [nucleoplasm] (R-HSA-68553)	0.947	17
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.916	8
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.903	22
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.855	10
UniProt:P33992 MCM5	1	MCM5 [nucleoplasm] (R-HSA-68551)	0.8	5
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.78	7
UniProt:P62805 H4C1	17	HIST1H4A [extracellular region] (R-HSA-977569) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.748	9
UniProt:Q9BTE3 MCMBP			0.723	4
UniProt:Q9NVP2 ASF1B			0.708	4
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.669	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.657	3
UniProt:Q96H20 SNF8	1	SNF8 [cytosol] (R-HSA-917711)	0.633	8
UniProt:P68431 H3C1	20	HIST1H3A [extracellular region] (R-HSA-977570) 2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288)	0.623	6
UniProt:O43823 AKAP8			0.581	7
UniProt:Q71DI3 H3C15	20	HIST2H3A [extracellular region] (R-HSA-977578) 2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) AcK24-HIST2H3A [nucleoplasm] (R-HSA-4568747) AcK19-HIST2H3A [nucleoplasm] (R-HSA-4568750) AcK5-HIST2H3A [nucleoplasm] (R-HSA-4568752) Ack15-HIST2H3A [nucleoplasm] (R-HSA-4549224) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197)	0.576	5
UniProt:P49450 CENPA	2	CENPA [nucleoplasm] (R-HSA-606322) CENPA [cytosol] (R-HSA-375317)	0.576	3
UniProt:O75419 CDC45	1	CDC45 [nucleoplasm] (R-HSA-68563)	0.574	2
UniProt:P84243 H3-3A	15	H3F3A [extracellular region] (R-HSA-977567) MeK-H3F3A [nucleoplasm] (R-HSA-427369) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.544	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.499	2
UniProt:P03433 PA	4	PA [extracellular region] (R-FLU-169243) PA [endosome lumen] (R-FLU-189131) PA [nucleoplasm] (R-FLU-188877) PA [cytosol] (R-FLU-195948)	0.462	2

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