Reactome | CDC45 [nucleoplasm]

CDC45 [nucleoplasm]

Stable Identifier

R-HSA-68563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cdc45, CDC45-related protein, PORC-PI-1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75419 CDC45

Gene Names

CDC45, CDC45L, CDC45L2, UNQ374/PRO710

Chain

chain:1-566

Reference Genes

BioGPS Gene:8318 CDC45

COSMIC (genes):CDC45 CDC45

CTD Gene:8318 CDC45

dbSNP Gene:8318 CDC45

ENSEMBL:ENSG00000093009 CDC45

ENSEMBL_homo_sapiens_GENE:ENSG00000093009.11 CDC45

HGNC:1739 CDC45

KEGG Gene (Homo sapiens):8318 CDC45

Monarch:8318 CDC45

NCBI Gene:8318 CDC45

OMIM:603465 CDC45

UCSC:O75419 CDC45

Reference Transcript

Other Identifiers

11719699_a_at

11745049_a_at

11751123_a_at

16927052

204126_PM_s_at

204126_s_at

37458_at

3936918

3936919

3936920

3936921

3936922

3936923

3936925

3936928

3936929

3936930

3936931

3936933

3936936

3936937

3936938

3936939

3936940

3936941

3936942

3936943

3936944

3936946

8071212

8318

GE54724

GO:0000076

GO:0000228

GO:0000278

GO:0000727

GO:0003677

GO:0003682

GO:0003688

GO:0003697

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005813

GO:0005815

GO:0005856

GO:0005929

GO:0006260

GO:0006268

GO:0006270

GO:0006281

GO:0006310

GO:0007049

GO:0023052

GO:0031261

GO:0036064

GO:0043226

GO:0065003

GO:0071162

GO:1902977

ILMN_1670238

PH_hs_0006287

PH_hs_0040528

TC22000046.hg

g4502712_3p_s_at

Participates

as a component of

as an input of

as an output of

CDC45 gene expression is stimulated by E2F1 (Homo sapiens)

Inferred To

cdc45 [nucleoplasm] (Danio rerio)

cdc45 [nucleoplasm] (Dictyostelium discoideum)

CDC45 [nucleoplasm] (Bos taurus)

CDC45 [nucleoplasm] (Canis familiaris)

CDC45 [nucleoplasm] (Gallus gallus)

CDC45 [nucleoplasm] (Saccharomyces cerevisiae)

CDC45 [nucleoplasm] (Sus scrofa)

evl-18 [nucleoplasm] (Caenorhabditis elegans)

sna41 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of CDC45 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of CDC45 [nucleoplasm] (Xenopus tropicalis)

Cdc45 [nucleoplasm] (Drosophila melanogaster)

Cdc45 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_001171482.1, XP_005261342.1, NP_001171481.1, NP_003495.1, XP_011528720.1, XP_011528717.1

OpenTargets

ENSG00000093009

GeneCards

O75419

ZINC - Substances

CDC45_HUMAN

HPA

ENSG00000093009-CDC45

ZINC target

O75419

Ensembl

ENSP00000384978, ENST00000437685, ENST00000404724, ENSP00000405726, ENST00000263201, ENSP00000263201, ENSG00000093009

PRO

O75419

Pharos - Targets

O75419

ZINC - Predictions - Purchasable

CDC45_HUMAN

Orphanet

23944

PDB

7PLO, 7PFO, 6XTY, 5DGO, 6XTX

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q53EZ4 CEP55			0.781	7
UniProt:Q9HAW4 CLSPN	5	PolyUb-CLSPN [nucleoplasm] (R-HSA-6783087) CLSPN(1-1072) [nucleoplasm] (R-HSA-351929) CLSPN(1073-1332) [nucleoplasm] (R-HSA-351935) CLSPN [nucleoplasm] (R-HSA-176282) p-T916,S945-CLSPN [nucleoplasm] (R-HSA-176296)	0.677	5
UniProt:Q14691 GINS1	1	GINS1 [nucleoplasm] (R-HSA-176955)	0.623	4
UniProt:P15927 RPA2	2	RPA2 [nucleoplasm] (R-HSA-68457) p-S33-RPA2 [nucleoplasm] (R-HSA-5685148)	0.576	4
UniProt:Q9BRT9 GINS4	1	GINS4 [nucleoplasm] (R-HSA-176963)	0.574	3
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.574	2
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.571	2
UniProt:P61018 RAB4B	5	GGC-RAB4B [cytosol] (R-HSA-8874049) RAB4B [cytosol] (R-HSA-8873680) RAB4B [plasma membrane] (R-HSA-6804989) RAB4B [secretory granule membrane] (R-HSA-6804976) GGC-RAB4B [recycling endosome membrane] (R-HSA-8875675)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
IntAct:EBI-15634422 H3K9-2			0.544	2
UniProt:Q92547 TOPBP1	1	TOPBP1 [nucleoplasm] (R-HSA-5684878)	0.544	6
UniProt:Q9NYP3 DONS			0.504	5