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What is Reactome ?
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Digital Preservation
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E2F1 [nucleoplasm]
Stable Identifier
R-HSA-68639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor E2F1, E2F-1, Retinoblastoma binding protein 3, RBBP-3, PRB-binding protein E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 (Homo sapiens)
CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
RB1:E2F1,E2F2,E2F3:TFDP1,TFDP2: [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
Inhibition of replication initiation of damaged DNA by RB1/E2F1 (Homo sapiens)
Replication initiation regulation by Rb1/E2F1 (Homo sapiens)
Aborted replication complex [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
G1/S-Specific Transcription (Homo sapiens)
CCNA1 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
CCNE1 gene transcription is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNE1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
CDC45 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC45 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
CDT1 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDT1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
DHFR gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the CCNA1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the CCNE1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CCNE1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDC25A gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDC45 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC45 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDC6 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDK1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the CDT1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDT1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the DHFR gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:DHFR gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the FBXO5 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:FBXO5 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the ORC1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the PCNA gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the POLA1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:POLA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the RRM2 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:RRM2 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the TK1 gene promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:TK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
FBXO5 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:FBXO5 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
ORC1 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:ORC1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
POLA1 gene transcription is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:POLA1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:RRM2 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
TK1 gene expression is stimulated by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:TK1 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
TYMS gene expression (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2 Phase (Homo sapiens)
Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3 (Homo sapiens)
CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160) (Homo sapiens)
CCNA:p-T160-CDK2:E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:CDC25A gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oncogene Induced Senescence (Homo sapiens)
E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter (Homo sapiens)
DP1/2: E2F1/2/3: SP1: CDKN2A Gene [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA (Homo sapiens)
DP1/2: E2F1/2/3: SP1: CDKN2A Gene [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
E2F1/2/3 stimulates EED transcription (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
EED Gene:E2F1/2/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
EZH2 Gene:E2F1/2/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/2/3 stimulates SUZ12 transcription (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
SUZ12 Gene:E2F1/2/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/2/3:DP1/2 binds EED gene promoter (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
EED Gene:E2F1/2/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/2/3:DP1/2 binds EZH2 gene promoter (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
EZH2 Gene:E2F1/2/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/2/3:DP1/2 binds SUZ12 gene promoter (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
SUZ12 Gene:E2F1/2/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
CEBPA binds MYC gene:E2F1 (Homo sapiens)
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds the promoter of the MYC gene (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
MYC gene expression is enhanced by E2F1, STAT3, and CEBPB and repressed by CEBPA (Homo sapiens)
MYC gene:CEBPA:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
MYC gene:E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of mitotic cell cycle (Homo sapiens)
Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects (Homo sapiens)
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) (Homo sapiens)
Defective RB1 does not bind E2F1,(E2F2,E2F3) (Homo sapiens)
E2F1,(E2F2,E2F3):TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1,(E2F2,E2F3) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
APAF1 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2):APAF1 gene [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds APAF1 gene promoter (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2):APAF1 gene [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 binds RAD51 gene promoter (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2):RAD51 gene [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2):RAD51 gene [nucleoplasm] (Homo sapiens)
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
RRM2 gene expression is stimulated by E2F1 and inhibited by E2F6 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2:RRM2 gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of NOXA and translocation to mitochondria (Homo sapiens)
E2F1 binds PMAIP1 (NOXA) promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:PMAIP1 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Transactivation of PMAIP1 (NOXA) by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:PMAIP1 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
E2F1 binds BBC3 (PUMA) promoter (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:BBC3 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Transactivation of BBC3 (PUMA) by E2F1 (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1:TFDP1:BBC3 Gene [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
E2F1/3:DP1/2 binds NOTCH1 promoter (Homo sapiens)
E2F1/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/3:DP1/2:NOTCH1 Gene [nucleoplasm] (Homo sapiens)
E2F1/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
NOTCH1 gene transcription (Homo sapiens)
E2F1/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
E2F1/3:DP1/2:NOTCH1 Gene [nucleoplasm] (Homo sapiens)
E2F1/3:DP1/2 [nucleoplasm] (Homo sapiens)
E2F1/E2F3 [nucleoplasm] (Homo sapiens)
E2F1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01094 E2F1
Gene Names
E2F1, RBBP3
Chain
chain:1-437
Reference Genes
BioGPS Gene:1869 E2F1
COSMIC (genes):E2F1 E2F1
CTD Gene:1869 E2F1
dbSNP Gene:1869 E2F1
ENSEMBL:ENSG00000101412 E2F1
HGNC:3113 E2F1
KEGG:hsa:1869 E2F1
Monarch:1869 E2F1
NCBI Gene:1869 E2F1
OMIM:189971 E2F1
UCSC:Q01094 E2F1
Reference Transcript
RefSeq:NM_005225.2 E2F1
Other Identifiers
11723713_at
1322_at
16918445
1869
2028_PM_s_at
2028_s_at
204947_PM_at
204947_at
3903124
3903125
3903126
3903147
3903148
3903149
3903150
3903151
3903153
3903154
3903155
3903157
3903158
3903159
3903161
3903162
3903163
3903164
8065710
A_23_P80032
GE60538
GO:0000077
GO:0000122
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0000987
GO:0001216
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005813
GO:0005815
GO:0006351
GO:0006355
GO:0006357
GO:0006915
GO:0008630
GO:0010628
GO:0012501
GO:0030900
GO:0032496
GO:0032991
GO:0035189
GO:0043065
GO:0043226
GO:0043276
GO:0043392
GO:0043565
GO:0045599
GO:0045892
GO:0045893
GO:0045944
GO:0046983
GO:0048146
GO:0048255
GO:0048856
GO:0051726
GO:0060090
GO:0070345
GO:0071466
GO:0072332
GO:0090575
GO:0140110
GO:0140297
GO:1990086
GO:1990837
GO:2000045
HMNXSV003055600
ILMN_2051469
PH_hs_0005226
S49592_s_at
TC20000773.hg
U47677_at
g12669910_3p_s_at
Participates
as a member of
E2F1,(E2F2,E2F3) [nucleoplasm] (Homo sapiens)
E2F1/2/3 [nucleoplasm] (Homo sapiens)
E2F1/E2F3 [nucleoplasm] (Homo sapiens)
as an output of
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression (Homo sapiens)
E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2 (Homo sapiens)
as a component of
E2F1:(TFDP1,TFDP2) [nucleoplasm] (Homo sapiens)
E2F1:TFDP1,TFDP2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-E2F1 [nucleoplasm]
Inferred To
PXMP4 [nucleoplasm]
(Canis familiaris)
e2f1 [nucleoplasm]
(Xenopus tropicalis)
E2F [nucleoplasm]
(Dictyostelium discoideum)
E2f1 [nucleoplasm]
(Drosophila melanogaster)
E2f1 [nucleoplasm]
(Mus musculus)
E2f1 [nucleoplasm]
(Rattus norvegicus)
E2F1 [nucleoplasm]
(Bos taurus)
E2F1 [nucleoplasm]
(Gallus gallus)
E2F1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_005216.1
OpenTargets
ENSG00000101412
ENSEMBL
ENSP00000345571
,
ENST00000343380
HPA
ENSG00000101412-E2F1
PRO
Q01094
Pharos - Targets
Q01094
PDB
6ULS
,
5M9N
,
1H24
,
2AZE
,
6G0P
,
1O9K
,
5M9O
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.97
30
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.95
17
UniProt:P03129 VE7
0.77
6
UniProt:Q14188 TFDP2
1
TFDP2 [nucleoplasm]
(R-HSA-1362225)
0.725
6
UniProt:Q92547 TOPBP1
1
TOPBP1 [nucleoplasm]
(R-HSA-5684878)
0.704
4
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.656
3
UniProt:Q92830 KAT2A
1
KAT2A [nucleoplasm]
(R-HSA-3006516)
0.65
3
UniProt:Q14684 RRP1B
0.649
10
UniProt:O14744 PRMT5
3
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
0.646
8
UniProt:Q8NEM0 MCPH1
1
MCPH1 [nucleoplasm]
(R-HSA-2429638)
0.633
6
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.615
3
UniProt:P09874 PARP1
4
PARP1 [nucleoplasm]
(R-HSA-201568)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
0.609
3
UniProt:Q14201 BTG3
0.602
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.589
2
UniProt:Q96JM7 LMBL3
0.589
2
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.564
2
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q92466 DDB2
3
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
0.544
2
IntAct:EBI-2549087 CASP7
0.527
2
IntAct:EBI-5279495 E2F1
0.527
2
IntAct:EBI-2549104 CCNA2
0.527
3
IntAct:EBI-2549096 TP73
0.527
3
IntAct:EBI-20620429 DIABLO
0.524
2
UniProt:Q96IZ0 PAWR
0.524
2
UniProt:Q9Y618 NCOR2
2
NCOR2 [nucleoplasm]
(R-HSA-442469)
monoSUMO1-K672-NCOR2 [nucleoplasm]
(R-HSA-3927904)
0.524
2
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.524
2
UniProt:Q923E4 Sirt1
2
Sirt1 [nucleoplasm]
(R-MMU-5211238)
SIRT1 [nucleoplasm]
(R-MMU-427531)
0.524
3
UniProt:Q9UPP1 PHF8
1
PHF8 [nucleoplasm]
(R-HSA-5423096)
0.499
2
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.462
2
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