Reactome | E2F1 [nucleoplasm]

E2F1 [nucleoplasm]

Stable Identifier

R-HSA-68639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor E2F1, E2F-1, Retinoblastoma binding protein 3, RBBP-3, PRB-binding protein E2F-1, PBR3, Retinoblastoma-associated protein 1, RBAP-1

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Locations in the PathwayBrowser for interactor UniProt:Q92547 TOPBP1

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External Reference Information

External Reference

UniProt:Q01094 E2F1

Gene Names

E2F1, RBBP3

Chain

chain:1-437

Reference Genes

BioGPS Gene:1869 E2F1

COSMIC (genes):E2F1 E2F1

CTD Gene:1869 E2F1

dbSNP Gene:1869 E2F1

ENSEMBL:ENSG00000101412 E2F1

ENSEMBL_homo_sapiens_GENE:ENSG00000101412.13 E2F1

HGNC:3113 E2F1

KEGG Gene (Homo sapiens):1869 E2F1

Monarch:1869 E2F1

NCBI Gene:1869 E2F1

OMIM:189971 E2F1

UCSC:Q01094 E2F1

Reference Transcript

RefSeq:NM_005225.2 E2F1

Other Identifiers

11723713_at

1322_at

16918445

1869

2028_PM_s_at

2028_s_at

204947_PM_at

204947_at

3903124

3903125

3903126

3903147

3903148

3903149

3903150

3903151

3903153

3903154

3903155

3903157

3903158

3903159

3903161

3903162

3903163

3903164

8065710

A_23_P80032

GE60538

GO:0000077

GO:0000082

GO:0000122

GO:0000278

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0000987

GO:0001216

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0006351

GO:0006355

GO:0006357

GO:0006915

GO:0007049

GO:0008630

GO:0010628

GO:0012501

GO:0016071

GO:0023052

GO:0030154

GO:0030900

GO:0032991

GO:0035189

GO:0043065

GO:0043226

GO:0043276

GO:0043392

GO:0043565

GO:0045599

GO:0045892

GO:0045893

GO:0045944

GO:0046983

GO:0048146

GO:0048255

GO:0048856

GO:0051726

GO:0060090

GO:0070345

GO:0071466

GO:0072332

GO:0090575

GO:0140110

GO:0140297

GO:1990086

GO:1990837

GO:2000045

HMNXSV003055600

ILMN_2051469

PH_hs_0005226

S49592_s_at

TC20000773.hg

U47677_at

g12669910_3p_s_at

Participates

as a member of

as an output of

as a component of

Other forms of this molecule

p-E2F1 [nucleoplasm]

Inferred To

PXMP4 [nucleoplasm] (Canis familiaris)

e2f1 [nucleoplasm] (Xenopus tropicalis)

E2F [nucleoplasm] (Dictyostelium discoideum)

E2f1 [nucleoplasm] (Drosophila melanogaster)

E2f1 [nucleoplasm] (Mus musculus)

E2f1 [nucleoplasm] (Rattus norvegicus)

E2F1 [nucleoplasm] (Bos taurus)

E2F1 [nucleoplasm] (Gallus gallus)

E2F1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005216.1

OpenTargets

ENSG00000101412

GeneCards

Q01094

HPA

ENSG00000101412-E2F1

Ensembl

ENSG00000101412, ENST00000343380, ENSP00000345571

PRO

Q01094

Pharos - Targets

Q01094

Orphanet

28512

PDB

1O9K, 5M9O, 6ULS, 6G0P, 1H24, 5M9N, 2AZE

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.97	30
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.95	17
UniProt:P03129 VE7			0.77	6
UniProt:Q14188 TFDP2	1	TFDP2 [nucleoplasm] (R-HSA-1362225)	0.725	6
UniProt:Q92547 TOPBP1	1	TOPBP1 [nucleoplasm] (R-HSA-5684878)	0.704	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.656	3
UniProt:Q92830 KAT2A	1	KAT2A [nucleoplasm] (R-HSA-3006516)	0.65	3
UniProt:Q14684 RRP1B			0.649	10
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.646	8
UniProt:Q8NEM0 MCPH1	1	MCPH1 [nucleoplasm] (R-HSA-2429638)	0.633	6
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.615	3
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.609	3
UniProt:Q14201 BTG3			0.602	3
UniProt:Q96JM7 LMBL3			0.589	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.589	2
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.564	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) PAR-DDB2 [nucleoplasm] (R-HSA-5696654) DDB2 [nucleoplasm] (R-HSA-53491)	0.544	2
IntAct:EBI-2549096 TP73			0.527	3
IntAct:EBI-2549104 CCNA2			0.527	3
IntAct:EBI-5279495 E2F1			0.527	2
IntAct:EBI-2549087 CASP7			0.527	2
UniProt:Q96IZ0 PAWR			0.524	2
IntAct:EBI-20620429 DIABLO			0.524	2
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) STAT1 [cytosol] (R-HSA-629622)	0.524	2
UniProt:Q9Y618 NCOR2	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.524	2
UniProt:Q923E4 Sirt1	2	Sirt1 [nucleoplasm] (R-MMU-5211238) SIRT1 [nucleoplasm] (R-MMU-427531)	0.524	3
UniProt:Q9UPP1 PHF8	1	PHF8 [nucleoplasm] (R-HSA-5423096)	0.499	2
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.462	2

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