Reactome | PSMA3 [cytosol]

PSMA3 [cytosol]

Stable Identifier

R-HSA-68728

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit alpha-7

Locations in the PathwayBrowser for interactor UniProt:Q9BTL3 RAMAC

Expand all

External Reference Information

External Reference

UniProt:P25788 PSMA3

Gene Names

PSMA3, HC8, PSC8

Chain

initiator methionine:, chain:2-255

Reference Genes

BioGPS Gene:5684 PSMA3

COSMIC (genes):PSMA3 PSMA3

CTD Gene:5684 PSMA3

dbSNP Gene:5684 PSMA3

ENSEMBL:ENSG00000100567 PSMA3

HGNC:9532 PSMA3

KEGG:hsa:5684 PSMA3

Monarch:5684 PSMA3

NCBI Gene:5684 PSMA3

OMIM:176843 PSMA3

OMIM:176845 PSMA3

UCSC:P25788 PSMA3

Reference Transcript

Participates

as an input of

as a component of

Other forms of this molecule

PSMA3 [nucleoplasm]

Inferred To

psma3 [cytosol] (Danio rerio)

psma3 [cytosol] (Xenopus tropicalis)

PRE10 [cytosol] (Saccharomyces cerevisiae)

Prosalpha7 [cytosol] (Drosophila melanogaster)

Ghost homologue of PSMA3 [cytosol] (Caenorhabditis elegans)

bPSMA3 [cytosol] (Bos taurus)

psmA3 [cytosol] (Dictyostelium discoideum)

pre10 [cytosol] (Schizosaccharomyces pombe)

PSMA3 [cytosol] (Canis familiaris)

PSMA3 [cytosol] (Gallus gallus)

PSMA3 [cytosol] (Plasmodium falciparum)

PSMA3 [cytosol] (Sus scrofa)

Psma3 [cytosol] (Mus musculus)

Psma3 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_687033.1, NP_002779.1

OpenTargets

ENSG00000100567

ENSEMBL

ENSP00000216455, ENST00000216455, ENSP00000390491, ENST00000412908, ENSG00000100567

GeneCards

PSMA3

HPA

ENSG00000100567-PSMA3

PRO

P25788

Pharos - Targets

P25788

GlyGen

P25788

PDB

7W37, 6MSG, 6WJN, 5T0G, 7W3K, 7QXP, 8QYM, 5GJQ, 7QYB, 5LF3, 7B12, 5LF7, 7NAQ, 8QYJ, 5VFO, 6WJD, 7V5M, 8QZ9, 5VFS, 6RGQ, 5VFP, 6MSK, 7W3G, 7W3I, 5GJR, 7NAN, 7W3F, 7QXX, 7V5G, 5T0C, 8QYL, 7PG9, 6KWY, 7NHT, 5LEZ, 5LF4, 4R67, 6R70, 7NAO, 8TM6, 8UD9, 5A0Q, 7W3H, 5VFR, 6MSJ, 6MSB, 7W3A, 5M32, 7QXW, 7W3M, 5T0J, 7QXN, 6MSE, 8QYS, 8QYO, 8CVT, 5L4G, 8CVR, 8TM5, 5DSV, 5LEX, 7E55, 5LF1, 7NAP, 7LXV, 6REY, 6AVO, 5VFQ, 5LN3, 7QXU, 6MSH, 4R3O, 7W38, 7W39, 5T0H, 8BZL, 5T0I, 6MSD, 7QY7, 7W3C, 8QYN, 7QYA, 5LE5, 5LEY, 8TM4, 5LF6, 5LF0, 8CXB, 8TM3, 7AWE, 6E5B, 5VFU, 5VFT, 7W3J, 7W3B, 6XMJ, 8CVS

Interactors (93)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.951	21
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.844	10
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.835	7
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.781	7
UniProt:Q8N895 ZN366			0.742	5
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.738	6
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.718	6
UniProt:Q6IPM2 IQCE	1	IQCE [cilium] (R-HSA-5633055)	0.666	4
UniProt:P23769 GATA2	1	GATA2 [nucleoplasm] (R-HSA-996735)	0.666	4
UniProt:Q66K41 Z385C			0.666	4
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.666	4
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.666	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.573	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.564	2
UniProt:Q7KZQ1 Q7KZQ1			0.556	3
UniProt:Q8N2R0 OSR2			0.556	3
UniProt:Q9HAA0 Q9HAA0			0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
IntAct:EBI-10202556 257000			0.556	3
IntAct:EBI-10202517 3845			0.556	3
UniProt:Q6RVD6 SPAT8			0.556	3
UniProt:Q7Z3D6 GLUCM			0.556	3
UniProt:Q96CW7 Q96CW7			0.556	3
UniProt:Q9BTL3 RAMAC			0.556	3
UniProt:Q6NUJ5 PWP2B			0.556	3
UniProt:O43251 RBFOX2	1	RBFOX2 [nucleoplasm] (R-HSA-6803504)	0.556	3
UniProt:P09228 CYTT			0.556	3
UniProt:Q7L9D0 Q7L9D0			0.556	3
UniProt:Q86UY5 FAM83A	1	FAM83A [cytosol] (R-HSA-9851391)	0.556	3
UniProt:Q8N779 Q8N779			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q86TB9 PATL1	1	PATL1 [cytosol] (R-HSA-2028617)	0.556	3
UniProt:Q9NRJ3 CCL28	1	CCL28 [extracellular region] (R-HSA-373300)	0.556	3
UniProt:Q8N7Y1 KIAS3			0.556	3
UniProt:Q9NQL9 DMRT3			0.556	3
IntAct:EBI-10202543 129807			0.556	3
UniProt:Q9Y4B4 ARIP4			0.556	3
UniProt:Q6UWL6 KIRREL2	1	KIRREL2 [plasma membrane] (R-HSA-936066)	0.556	3
UniProt:Q14D33 RTP5			0.556	3
IntAct:EBI-10202502 1535			0.556	3
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.556	3
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.556	3
UniProt:Q5JPT6 Q5JPT6			0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:Q96D16 Q96D16			0.556	3
UniProt:Q6PEX3 KRTAP26-1	1	KRTAP26-1 [cytosol] (R-HSA-6810244)	0.556	3
UniProt:Q9H6H2 Q9H6H2			0.556	3
UniProt:Q66K80 RUAS1			0.556	3
UniProt:Q96HZ7 URAS1			0.556	3
UniProt:P79522 PRR3			0.556	3
UniProt:Q5TAL4 Q5TAL4			0.556	3
UniProt:Q8IUC2 KRTAP8-1	1	KRTAP8-1 [cytosol] (R-HSA-6810288)	0.556	3
UniProt:A0A0S2Z5X4 A0A0S2Z5X4			0.556	3
UniProt:Q58A44 PCOTH			0.556	3
IntAct:EBI-10202530 284276			0.556	3
UniProt:P14678-2 SNRPB			0.556	3
UniProt:P16860 ANFB			0.556	3
UniProt:Q14CW7 Q14CW7			0.556	3
UniProt:O95561 CA105			0.556	3
UniProt:Q9BUF7 CRB3	1	CRB3 [plasma membrane] (R-HSA-420009)	0.556	3
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.556	3
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.556	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.556	3
UniProt:Q5W150 YT011			0.556	3
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.556	3
UniProt:Q8ND83 SLAI1			0.556	3
UniProt:Q96MZ4 F218A			0.556	3
UniProt:P48146 NPBWR2	1	NPBWR2 [plasma membrane] (R-HSA-374797)	0.556	3
UniProt:B2R550 B2R550			0.556	3
UniProt:Q8NAJ2 CI106			0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:Q8N0U1 Q8N0U1			0.556	3
UniProt:Q9H8E5 Q9H8E5			0.556	3
UniProt:Q9NWL9 Q9NWL9			0.556	3
UniProt:Q8TBN0 RAB3IL1	1	RAB3IL1 [cytosol] (R-HSA-8875296)	0.556	3
IntAct:EBI-10188417 1021			0.556	3
UniProt:Q14847 LASP1			0.556	3
UniProt:hCG_2003792 A0A024R5S0			0.556	3
UniProt:O95202 LETM1	2	LETM1 [endoplasmic reticulum membrane] (R-HSA-9714759) LETM1 [mitochondrial inner membrane] (R-HSA-8949702)	0.556	3
IntAct:EBI-10202577 83719			0.556	3
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.553	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	2
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	3
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [secretory granule lumen] (R-HSA-6803316)	0.527	4
UniProt:P29590 PML	5	PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.508	2
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.495	2
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.488	2

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