Reactome | PSMA3 [cytosol]

PSMA3 [cytosol]

Stable Identifier

R-HSA-68728

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit alpha-7

Locations in the PathwayBrowser for interactor UniProt:Q9H3S7 PTPN23

Expand all

External Reference Information

External Reference

UniProt:P25788 PSMA3

Gene Names

PSMA3, HC8, PSC8

Chain

initiator methionine:, chain:2-255

Reference Genes

COSMIC (genes):PSMA3 PSMA3

dbSNP Gene:5684 PSMA3

ENSEMBL:ENSG00000100567 PSMA3

Participates

as an input of

Formation of the outer ring of the 20S core particle of the spermatoproteasome (Homo sapiens)
Formation of the outer ring of the 20S core particle (Homo sapiens)

as a component of

Other forms of this molecule

PSMA3 [nucleoplasm]

Inferred To

psma3 [cytosol] (Danio rerio)

psma3 [cytosol] (Xenopus tropicalis)

PRE10 [cytosol] (Saccharomyces cerevisiae)

Prosalpha7 [cytosol] (Drosophila melanogaster)

Ghost homologue of PSMA3 [cytosol] (Caenorhabditis elegans)

bPSMA3 [cytosol] (Bos taurus)

psmA3 [cytosol] (Dictyostelium discoideum)

pre10 [cytosol] (Schizosaccharomyces pombe)

PSMA3 [cytosol] (Canis familiaris)

PSMA3 [cytosol] (Gallus gallus)

PSMA3 [cytosol] (Plasmodium falciparum)

PSMA3 [cytosol] (Sus scrofa)

Psma3 [cytosol] (Mus musculus)

Psma3 [cytosol] (Rattus norvegicus)

Interactors (93)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.951	21
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.844	10
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.835	7
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.781	7
UniProt:Q8N895 ZN366			0.742	5
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.738	6
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.718	6
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.666	4
UniProt:Q6IPM2 IQCE	1	IQCE [cilium] (R-HSA-5633055)	0.666	4
UniProt:P23769 GATA2	1	GATA2 [nucleoplasm] (R-HSA-996735)	0.666	4
UniProt:Q66K41 Z385C			0.666	4
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.666	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.573	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.564	2
UniProt:Q7KZQ1 Q7KZQ1			0.556	3
UniProt:Q8N2R0 OSR2			0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:Q9HAA0 Q9HAA0			0.556	3
UniProt:Q9NZ81 PRR13			0.556	3
IntAct:EBI-10202556 257000			0.556	3
IntAct:EBI-10202517 3845			0.556	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.556	3
UniProt:Q6RVD6 SPAT8			0.556	3
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.556	3
UniProt:Q7Z3D6 GLUCM			0.556	3
UniProt:Q96CW7 Q96CW7			0.556	3
UniProt:Q9BTL3 RAMAC			0.556	3
UniProt:Q6NUJ5 PWP2B			0.556	3
UniProt:O43251 RBFOX2	1	RBFOX2 [nucleoplasm] (R-HSA-6803504)	0.556	3
UniProt:P09228 CYTT			0.556	3
UniProt:Q7L9D0 Q7L9D0			0.556	3
UniProt:Q86UY5 FAM83A	1	FAM83A [cytosol] (R-HSA-9851391)	0.556	3
UniProt:Q8N779 Q8N779			0.556	3
UniProt:Q9BUF7 CRB3	1	CRB3 [plasma membrane] (R-HSA-420009)	0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q86TB9 PATL1	1	PATL1 [cytosol] (R-HSA-2028617)	0.556	3
UniProt:Q9NRJ3 CCL28	1	CCL28 [extracellular region] (R-HSA-373300)	0.556	3
UniProt:Q8N7Y1 KIAS3			0.556	3
UniProt:Q9NQL9 DMRT3			0.556	3
IntAct:EBI-10202543 129807			0.556	3
UniProt:Q9Y4B4 ARIP4			0.556	3
UniProt:Q6UWL6 KIRREL2	1	KIRREL2 [plasma membrane] (R-HSA-936066)	0.556	3
UniProt:Q14D33 RTP5			0.556	3
IntAct:EBI-10202502 1535			0.556	3
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.556	3
UniProt:Q9H8Y8 GORASP2	2	p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965) GORASP2 [Golgi membrane] (R-HSA-2422385)	0.556	3
UniProt:Q5JPT6 Q5JPT6			0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:Q96D16 Q96D16			0.556	3
UniProt:Q6PEX3 KRTAP26-1	1	KRTAP26-1 [cytosol] (R-HSA-6810244)	0.556	3
UniProt:Q9H6H2 Q9H6H2			0.556	3
UniProt:Q66K80 RUAS1			0.556	3
UniProt:Q96HZ7 URAS1			0.556	3
UniProt:P79522 PRR3			0.556	3
UniProt:Q5TAL4 Q5TAL4			0.556	3
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.556	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.556	3
UniProt:Q5W150 YT011			0.556	3
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.556	3
UniProt:Q8ND83 SLAI1			0.556	3
UniProt:Q96MZ4 F218A			0.556	3
UniProt:P48146 NPBWR2	1	NPBWR2 [plasma membrane] (R-HSA-374797)	0.556	3
UniProt:B2R550 B2R550			0.556	3
UniProt:Q8NAJ2 CI106			0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:Q8N0U1 Q8N0U1			0.556	3
UniProt:Q9H8E5 Q9H8E5			0.556	3
UniProt:Q9NWL9 Q9NWL9			0.556	3
UniProt:Q8TBN0 RAB3IL1	1	RAB3IL1 [cytosol] (R-HSA-8875296)	0.556	3
IntAct:EBI-10188417 1021			0.556	3
UniProt:Q14847 LASP1			0.556	3
UniProt:hCG_2003792 A0A024R5S0			0.556	3
UniProt:O95202 LETM1	2	LETM1 [endoplasmic reticulum membrane] (R-HSA-9714759) LETM1 [mitochondrial inner membrane] (R-HSA-8949702)	0.556	3
IntAct:EBI-10202577 83719			0.556	3
UniProt:O95561 CA105			0.556	3
UniProt:Q14CW7 Q14CW7			0.556	3
UniProt:P16860 ANFB			0.556	3
UniProt:P14678-2 SNRPB			0.556	3
IntAct:EBI-10202530 284276			0.556	3
UniProt:Q58A44 PCOTH			0.556	3
UniProt:A0A0S2Z5X4 A0A0S2Z5X4			0.556	3
UniProt:Q8IUC2 KRTAP8-1	1	KRTAP8-1 [cytosol] (R-HSA-6810288)	0.556	3
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.553	2
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	2
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.527	3
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.527	4
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.508	2
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.495	2
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.488	2