Reactome | PSMA6 [cytosol]

PSMA6 [cytosol]

Stable Identifier

R-HSA-68734

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit alpha type 6 , Proteasome iota chain, Macropain iota chain, Multicatalytic endopeptidase complex iota chain, 27 kDa prosomal protein, PROS-27, p27K

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60900 PSMA6

Gene Names

PSMA6, PROS27

Chain

chain:1-246

Reference Genes

BioGPS Gene:5687 PSMA6

COSMIC (genes):PSMA6 PSMA6

CTD Gene:5687 PSMA6

dbSNP Gene:5687 PSMA6

ENSEMBL:ENSG00000100902.11 PSMA6

HGNC:9535 PSMA6

KEGG Gene (Homo sapiens):5687 PSMA6

Monarch:5687 PSMA6

NCBI Gene:5687 PSMA6

OMIM:602855 PSMA6

UCSC:P60900 PSMA6

Reference Transcript

Other Identifiers

0003990368

11757295_x_at

208805_3p_at

208805_PM_at

208805_at

3532457

3532459

3532460

3532461

3532462

3532465

3532468

3532469

3532472

3532473

3532475

3532479

3532480

3532481

3532482

36122_at

4030209

4030210

4030212

4030213

5687

7973936

A_23_P25735

GE59844

GO:0000502

GO:0000932

GO:0003723

GO:0004175

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0005844

GO:0006351

GO:0006355

GO:0006511

GO:0006954

GO:0010498

GO:0016363

GO:0016787

GO:0019773

GO:0030016

GO:0030017

GO:0030163

GO:0032991

GO:0035639

GO:0043161

GO:0043226

GO:0050727

GO:0051059

GO:0051092

GO:0051603

GO:0070062

GO:0140096

HMNXSV003043053

ILMN_1704094

ILMN_2151818

TC14002294.hg

X59417_at

g12804240_3p_at

g12804240_3p_s_at

Participates

as a component of

26S proteasome [cytosol] (Homo sapiens)

Other forms of this molecule

PSMA6 [nucleoplasm]

Inferred To

Homologues of PSMA6 [cytosol] (Canis familiaris)

psmA6 [cytosol] (Dictyostelium discoideum)

Ghost homologue of PSMA6 [cytosol] (Sus scrofa)

Proteasome subunit alpha type-6 [cytosol] (Mus musculus)

SCL1 [cytosol] (Saccharomyces cerevisiae)

Psma6 [cytosol] (Rattus norvegicus)

PSMA6 [cytosol] (Bos taurus)

PSMA6 [cytosol] (Canis familiaris)

PSMA6 [cytosol] (Danio rerio)

PSMA6 [cytosol] (Plasmodium falciparum)

PSMA6 [cytosol] (Schizosaccharomyces pombe)

Prosalpha1 [cytosol] (Drosophila melanogaster)

pas-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002782.1, NP_001269161.1, NP_001269163.1, XP_016876957.1, NP_001269162.1

OpenTargets

ENSG00000100902

HPA

ENSG00000100902-PSMA6

GeneCards

P60900

Ensembl

ENST00000622405, ENST00000540871, ENSP00000261479, ENST00000261479, ENSG00000100902, ENSP00000479620, ENSP00000444844, ENST00000555764, ENSP00000452566

PRO

P60900

Pharos - Targets

P60900

PDB

6MSD, 5LF1, 5VFS, 5VFO, 5LF4, 4R67, 5T0G, 6XMJ, 6WJD, 6R70, 5VFT, 7AWE, 5LF6, 5T0H, 5VFQ, 7V5G, 6KWY, 5LF7, 6REY, 5T0C, 5LEY, 5T0I, 5GJQ, 5LE5, 4R3O, 5M32, 5LF0, 7NHT, 5T0J, 6MSK, 6RGQ, 5LF3, 5VFP, 5A0Q, 5GJR, 7PG9, 6MSH, 6E5B, 7LXV, 6MSG, 5VFU, 6AVO, 7V5M, 5L4G, 6MSB, 5LEZ, 5VFR, 7B12, 5LEX, 6WJN, 5LN3

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:Q9BY67 CADM1	1	CADM1 [plasma membrane] (R-HSA-420589)	0.556	3
UniProt:P62875 POLR2L	2	POLR2L [nucleoplasm] (R-HSA-83715) POLR2L [cytosol] (R-HSA-1964467)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.495	2

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