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PSMA6 [cytosol]
Stable Identifier
R-HSA-68734
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proteasome subunit alpha-1
Locations in the PathwayBrowser for interactor UniProt:P62875 POLR2L
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Proteasome assembly (Homo sapiens)
Formation of the outer ring of the 20S core particle (Homo sapiens)
PSMA6 [cytosol] (Homo sapiens)
Formation of the outer ring of the 20S core particle of the spermatoproteasome (Homo sapiens)
PSMA6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60900 PSMA6
Gene Names
PSMA6, PROS27
Chain
chain:1-246
Reference Genes
BioGPS Gene:5687 PSMA6
COSMIC (genes):PSMA6 PSMA6
CTD Gene:5687 PSMA6
dbSNP Gene:5687 PSMA6
ENSEMBL:ENSG00000100902 PSMA6
HGNC:9535 PSMA6
KEGG:hsa:5687 PSMA6
Monarch:5687 PSMA6
NCBI Gene:5687 PSMA6
OMIM:602855 PSMA6
UCSC:P60900 PSMA6
Reference Transcript
RefSeq:NM_001282233.1 PSMA6
RefSeq:XM_017021468.1 PSMA6
RefSeq:NM_001282232.1 PSMA6
RefSeq:NM_001282234.1 PSMA6
RefSeq:NM_002791.2 PSMA6
Other Identifiers
11757295_x_at
208805_3p_at
208805_PM_at
208805_at
3085572
3532457
3532459
3532460
3532461
3532462
3532465
3532466
3532467
3532468
3532469
3532470
3532471
3532472
3532473
3532474
3532475
3532476
3532477
3532478
3532479
3532480
3532481
3532482
3532483
3532484
36122_at
4030209
4030210
4030212
4030213
5687
71040_at
7973936
A_14_P113003
A_23_P25735
A_24_P922120
GE596642
GE59844
GO:0000502
GO:0000932
GO:0003723
GO:0003824
GO:0004175
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0005840
GO:0006355
GO:0006511
GO:0010498
GO:0016363
GO:0016787
GO:0019773
GO:0030016
GO:0030017
GO:0030163
GO:0035639
GO:0043161
GO:0043226
GO:0050727
GO:0051059
GO:0051092
GO:0051603
GO:0070062
GO:0140096
HMNXSV003043053
ILMN_1704094
ILMN_2151818
TC14002294.hg
X59417_at
g12804240_3p_at
g12804240_3p_s_at
Participates
as an input of
Formation of the outer ring of the 20S core particle of the spermatoproteasome (Homo sapiens)
Formation of the outer ring of the 20S core particle (Homo sapiens)
as a component of
20S sCP outer ring [cytosol] (Homo sapiens)
20S CP outer ring [cytosol] (Homo sapiens)
Other forms of this molecule
PSMA6 [nucleoplasm]
Inferred To
Homologues of PSMA6 [cytosol]
(Canis familiaris)
psmA6 [cytosol]
(Dictyostelium discoideum)
bPSMA6 [cytosol]
(Bos taurus)
psma6 [cytosol]
(Xenopus tropicalis)
psma6b [cytosol]
(Danio rerio)
SCL1 [cytosol]
(Saccharomyces cerevisiae)
LOC100686569 [cytosol]
(Canis familiaris)
Psma6 [cytosol]
(Mus musculus)
Psma6 [cytosol]
(Rattus norvegicus)
PSMA6 [cytosol]
(Canis familiaris)
PSMA6 [cytosol]
(Gallus gallus)
PSMA6 [cytosol]
(Plasmodium falciparum)
PSMA6 [cytosol]
(Schizosaccharomyces pombe)
PSMA6 [cytosol]
(Sus scrofa)
Prosalpha1 [cytosol]
(Drosophila melanogaster)
pas-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_016876957.1
,
NP_002782.1
,
NP_001269162.1
,
NP_001269161.1
,
NP_001269163.1
OpenTargets
ENSG00000100902
ENSEMBL
ENST00000261479
,
ENSP00000479620
,
ENSP00000444844
,
ENSP00000261479
,
ENST00000622405
,
ENSP00000452566
,
ENST00000555764
,
ENST00000540871
HPA
ENSG00000100902-PSMA6
PRO
P60900
Pharos - Targets
P60900
GlyGen
P60900
PDB
5T0H
,
5T0C
,
5T0I
,
7PG9
,
8CVR
,
5L4G
,
7QYA
,
7V5G
,
7W3M
,
7W3K
,
7QXN
,
7W3F
,
5GJQ
,
5LN3
,
7W38
,
5LF1
,
6MSB
,
8QYO
,
7W3H
,
8QYL
,
6KWY
,
7V5M
,
7W39
,
5VFS
,
7NAN
,
5VFR
,
6WJN
,
7B12
,
5VFU
,
6MSH
,
7W3A
,
7W3I
,
5VFO
,
7QXW
,
6AVO
,
6E5B
,
8CXB
,
7LXV
,
5LEY
,
5LEZ
,
4R67
,
5LF3
,
4R3O
,
5M32
,
5T0G
,
5LE5
,
5T0J
,
6REY
,
8CVT
,
8CVS
,
8BZL
,
7QYB
,
8QYS
,
6MSD
,
8QZ9
,
7W3C
,
7QXX
,
7QXP
,
7QY7
,
5LF0
,
6WJD
,
8QYM
,
6MSK
,
7NAO
,
7W3B
,
7NAQ
,
7W37
,
7W3G
,
7NAP
,
5VFT
,
7W3J
,
8QYN
,
6RGQ
,
5VFQ
,
6XMJ
,
7QXU
,
5A0Q
,
8UD9
,
5VFP
,
6MSG
,
5GJR
,
7NHT
,
8QYJ
,
6R70
,
7AWE
,
5LEX
,
5LF6
,
5LF7
,
5LF4
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.89
12
UniProt:O14818 PSMA7
2
PSMA7 [nucleoplasm]
(R-HSA-174351)
PSMA7 [cytosol]
(R-HSA-68736)
0.85
13
UniProt:P25787 PSMA2
5
PSMA2 [cytosol]
(R-HSA-68726)
PSMA2 [nucleoplasm]
(R-HSA-174345)
PSMA2 [secretory granule lumen]
(R-HSA-6803329)
PSMA2 [extracellular region]
(R-HSA-6806506)
PSMA2 [ficolin-1-rich granule lumen]
(R-HSA-6803285)
0.845
10
UniProt:P25788 PSMA3
2
PSMA3 [cytosol]
(R-HSA-68728)
PSMA3 [nucleoplasm]
(R-HSA-174323)
0.844
10
UniProt:P49721 PSMB2
2
PSMB2 [cytosol]
(R-HSA-68744)
PSMB2 [nucleoplasm]
(R-HSA-174335)
0.788
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.744
5
UniProt:P20618 PSMB1
7
PSMB1 [cytosol]
(R-HSA-68738)
PSMB1 [nucleoplasm]
(R-HSA-174347)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
0.725
5
UniProt:P25789 PSMA4
2
PSMA4 [cytosol]
(R-HSA-68730)
PSMA4 [nucleoplasm]
(R-HSA-174324)
0.669
5
UniProt:O43242 PSMD3
5
PSMD3 [cytosol]
(R-HSA-68798)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q99436 PSMB7
7
PSMB7 [cytosol]
(R-HSA-68759)
PSMB7 [nucleoplasm]
(R-HSA-174331)
PSMB7 [secretory granule lumen]
(R-HSA-6803279)
PSMB7 [extracellular region]
(R-HSA-6806449)
PSMB7 [ficolin-1-rich granule lumen]
(R-HSA-6803312)
pro-PSMB7 [cytosol]
(R-HSA-9908145)
PSMB7(1-43) [cytosol]
(R-HSA-9908129)
0.643
4
UniProt:P28066 PSMA5
5
PSMA5 [cytosol]
(R-HSA-68732)
PSMA5 [nucleoplasm]
(R-HSA-174340)
PSMA5 [secretory granule lumen]
(R-HSA-6803316)
PSMA5 [extracellular region]
(R-HSA-6806459)
PSMA5 [ficolin-1-rich granule lumen]
(R-HSA-6803328)
0.643
6
UniProt:P28065 PSMB9
3
pro-PSMB9 [cytosol]
(R-HSA-9908136)
PSMB9 [cytosol]
(R-HSA-68765)
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
0.643
5
UniProt:P49720 PSMB3
2
PSMB3 [cytosol]
(R-HSA-68747)
PSMB3 [nucleoplasm]
(R-HSA-174341)
0.643
5
UniProt:P28070 PSMB4
4
PSMB4 [cytosol]
(R-HSA-68750)
PSMB4 [nucleoplasm]
(R-HSA-174343)
pro-PSMB4 [cytosol]
(R-HSA-9908138)
PSMB4(1-45) [cytosol]
(R-HSA-9908122)
0.643
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
16
UniProt:Q15008 PSMD6
5
PSMD6 [cytosol]
(R-HSA-68804)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
0.564
2
UniProt:Q9UNM6 PSMD13
5
PSMD13 [cytosol]
(R-HSA-68794)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
0.564
2
UniProt:Q0VDD7 BRME1
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:Q969J2 ZKSCAN4
1
ZKSCAN4 [nucleoplasm]
(R-HSA-1027423)
0.556
3
UniProt:P84090 ERH
0.556
3
UniProt:Q8TC21 ZNF596
1
ZNF596 [nucleoplasm]
(R-HSA-2127570)
0.556
3
UniProt:Q8N9M1-2 C19ORF47
0.556
3
UniProt:A2RU48 SMCO3
0.556
3
UniProt:Q9BY67 CADM1
1
CADM1 [plasma membrane]
(R-HSA-420589)
0.556
3
UniProt:Q96N21 AP4AT
0.556
3
UniProt:Q8NCP5 ZBT44
0.556
3
UniProt:Q14D33 RTP5
0.556
3
UniProt:P62875 POLR2L
2
POLR2L [cytosol]
(R-HSA-1964467)
POLR2L [nucleoplasm]
(R-HSA-83715)
0.556
3
UniProt:Q9HCM9-2 TRIM39
0.556
5
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:Q9BT23 LIMD2
0.556
3
UniProt:Q6FI91 Q6FI91
0.556
3
UniProt:Q9HCM9 TRIM39
1
TRIM39 [cytosol]
(R-HSA-5688971)
0.556
3
UniProt:Q96K19 RN170
0.556
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q9Y244 POMP
1
POMP [cytosol]
(R-HSA-9908067)
0.527
4
UniProt:P62333 PSMC6
2
PSMC6 [cytosol]
(R-HSA-68783)
PSMC6 [nucleoplasm]
(R-HSA-174319)
0.495
2
IntAct:EBI-4399559 UBIQ
0.462
2
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