Reactome | PSMB2 [cytosol]

PSMB2 [cytosol]

Stable Identifier

R-HSA-68744

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit beta-4

Locations in the PathwayBrowser for interactor UniProt:A1A4E9 A1A4E9

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External Reference Information

External Reference

UniProt:P49721 PSMB2

Gene Names

PSMB2

Chain

chain:1-201

Reference Genes

BioGPS Gene:5690 PSMB2

COSMIC (genes):PSMB2 PSMB2

CTD Gene:5690 PSMB2

dbSNP Gene:5690 PSMB2

ENSEMBL:ENSG00000126067 PSMB2

HGNC:9539 PSMB2

KEGG:hsa:5690 PSMB2

Monarch:5690 PSMB2

NCBI Gene:5690 PSMB2

OMIM:602175 PSMB2

UCSC:P49721 PSMB2

Reference Transcript

RefSeq:NM_002794.4 PSMB2

Other Identifiers

11728193_a_at

11760100_x_at

1310_at

16685144

18670642

18670643

18670644

18670645

18670646

18670647

18670648

18670649

200039_PM_s_at

200039_s_at

201404_PM_x_at

201404_x_at

238425_PM_at

238425_at

2406243

2406244

2406246

2406247

2406248

2406249

2406250

2406251

2406252

2406253

2406254

2406255

2406256

2406258

2406261

2406264

2406265

2406361

44267_at

52297_at

5690

63021_at

66197_at

7892894

7893061

7893333

7893730

7893853

7894501

7894926

7895180

7895602

7896651

7914834

A_24_P284893

A_32_P212333

D26599_at

GE57142

GO:0000502

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0010498

GO:0014070

GO:0016020

GO:0019774

GO:0030163

GO:0043161

GO:0043226

GO:0051603

GO:0070062

HMNXSV003002055

Hs.285520.0.A1_3p_at

ILMN_1764794

PH_hs_0020020

TC01002498.hg

g4506194_3p_a_at

Participates

as an input of

as a component of

Other forms of this molecule

PSMB2 [nucleoplasm]

Inferred To

psmb2 [cytosol] (Danio rerio)

psmb2 [cytosol] (Xenopus tropicalis)

PSMB2 [cytosol] (Canis familiaris)

PSMB2 [cytosol] (Gallus gallus)

PSMB2 [cytosol] (Plasmodium falciparum)

PSMB2 [cytosol] (Schizosaccharomyces pombe)

PSMB2 [cytosol] (Sus scrofa)

Prosbeta4 [cytosol] (Drosophila melanogaster)

Psmb2 [cytosol] (Mus musculus)

Psmb2 [cytosol] (Rattus norvegicus)

PRE1 [cytosol] (Saccharomyces cerevisiae)

bPSMB2 [cytosol] (Bos taurus)

pbs-4 [cytosol] (Caenorhabditis elegans)

psmB2 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002785.1

ZINC - World Drugs

PSB2_HUMAN

Guide to Pharmacology - Targets

2405

OpenTargets

ENSG00000126067

ENSEMBL

ENST00000373237, ENSP00000362334

ZINC - FDA approved

PSB2_HUMAN

ZINC - Substances

PSB2_HUMAN

ZINC target

P49721

PRO

P49721

GlyGen

P49721

PDB

5T0J, 5LE5, 7QXX, 7QY7, 7QXP, 8QZ9, 7W3C, 8QYS, 6MSD, 5VFO, 5LF6, 7QXW, 6AVO, 5LEX, 5LF4, 7W3I, 5VFU, 5VFR, 6MSH, 7B12, 7W3A, 6WJN, 5LF7, 7NAN, 7W39, 7V5M, 5LF0, 6KWY, 5VFS, 7W3H, 6MSJ, 6MSB, 8QYO, 7W38, 5A0Q, 7LXV, 8CXB, 6E5B, 7QYA, 7PG9, 8CVR, 5LN3, 5T0H, 5T0I, 5T0C, 5L4G, 5GJQ, 7W3F, 7W3M, 7QXN, 7W3K, 7V5G, 6MSE, 5GJR, 5LEZ, 5VFP, 7NHT, 6MSG, 5LEY, 5LF3, 8UD9, 6RGQ, 5VFQ, 7QXU, 4R67, 6XMJ, 7W3J, 5LF1, 7NAP, 7W3G, 5VFT, 8QYN, 7W3B, 7NAQ, 7W37, 7NAO, 6MSK, 6WJD, 8QYM, 7AWE, 6R70, 8BZL, 7QYB, 8CVS, 6REY, 8CVT, 5T0G, 5M32, 4R3O

ZINC - Investigational

PSB2_HUMAN

HPA

ENSG00000126067-PSMB2

Pharos - Targets

P49721

ZINC - Predictions - Purchasable

PSB2_HUMAN

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.911	15
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.85	9
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.837	9
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.798	8
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.788	6
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.788	6
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.738	5
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.738	5
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.728	4
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.725	9
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.725	5
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.725	4
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.725	6
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.725	5
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.725	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.643	4
UniProt:P25789 PSMA4	2	PSMA4 [cytosol] (R-HSA-68730) PSMA4 [nucleoplasm] (R-HSA-174324)	0.643	4
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	5
UniProt:P28072 PSMB6	4	PSMB6 [cytosol] (R-HSA-68756) PSMB6 [nucleoplasm] (R-HSA-174342) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6(1-34) [cytosol] (R-HSA-9908141)	0.643	4
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) ub-AXIN2 [cytosol] (R-HSA-4641131) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859)	0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q7L273 KCTD9			0.556	3
UniProt:Q8IUB9 KRTAP19-1	1	KRTAP19-1 [cytosol] (R-HSA-6810285)	0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q3SYF9 KRTAP19-7	1	KRTAP19-7 [cytosol] (R-HSA-6810305)	0.556	3
UniProt:Q3LI70 KRTAP19-6	1	KRTAP19-6 [cytosol] (R-HSA-6810286)	0.556	3
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.527	3
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	3
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.527	3
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.527	3
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	3
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.527	3
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.527	2
UniProt:P62979 RPS27A	20	RPS27A(1-76) [endocytic vesicle membrane] (R-HSA-939208) RPS27A(77-156) [nucleoplasm] (R-HSA-6798734) Ub-33-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783024) Ub-63-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783200) Ub-6-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783040) Ub-11-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783085) Ub-48-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783075) Ub-29-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-6783146) Ub-63-RPS27A(1-76) [cytosol] (R-HSA-939248) RPS27A(1-76) [lysosomal lumen] (R-HSA-9660001) RPS27A(1-76) [cytosol] (R-HSA-939205) p-S65-RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834951) Ub-48-RPS27A(1-76) [cytosol] (R-HSA-939202) RPS27A(1-76) [mitochondrial outer membrane] (R-HSA-9834993) RPS27A(1-76) [late endosome lumen] (R-HSA-9660022) Ub-6-RPS27A(1-76) [nucleoplasm] (R-HSA-6782608) Ub-63-RPS27A(1-76) [nucleoplasm] (R-HSA-6782503) Ub-48-RPS27A(1-76) [nucleoplasm] (R-HSA-5683037) RPS27A(1-76) [nucleoplasm] (R-HSA-939849) Ub-11-RPS27A(1-76) [cytosol] (R-HSA-3095933)	0.527	2
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.527	2
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.527	2
UniProt:O95456 PSMG1	1	PSMG1 [cytosol] (R-HSA-9908050)	0.527	3
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.527	2
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.527	2
UniProt:Q53H80 AKIR2			0.527	2
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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