Reactome | PSMB3 [cytosol]

PSMB3 [cytosol]

Stable Identifier

R-HSA-68747

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome subunit beta-3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49720 PSMB3

Gene Names

PSMB3

Chain

initiator methionine:, chain:2-205

Reference Genes

BioGPS Gene:5691 PSMB3

CTD Gene:5691 PSMB3

dbSNP Gene:5691 PSMB3

ENSEMBL:ENSG00000275903 PSMB3

ENSEMBL:ENSG00000277791 PSMB3

ENSEMBL_homo_sapiens_GENE:ENSG00000275903.2 PSMB3

ENSEMBL_homo_sapiens_GENE:ENSG00000277791.5 PSMB3

HGNC:9540 PSMB3

KEGG Gene (Homo sapiens):5691 PSMB3

Monarch:5691 PSMB3

NCBI Gene:5691 PSMB3

OMIM:602176 PSMB3

UCSC:P49720 PSMB3

Reference Transcript

RefSeq:NM_002795.3 PSMB3

Other Identifiers

11715732_at

1309_at

16833698

201400_PM_at

201400_at

3719963

3719964

3719965

3719967

3719968

3719971

3719972

3719973

3719974

5691

8006812

A_23_P100576

A_33_P3234899

D26598_at

GE57141

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0010498

GO:0019774

GO:0030163

GO:0043161

GO:0043226

GO:0051603

GO:0070062

HMNXSV003043158

ILMN_1748651

TC17000466.hg

g4506196_3p_at

Participates

as a component of

as an input of

Other forms of this molecule

PSMB3 [nucleoplasm]

Inferred To

Ghost homologue of PSMB3 [cytosol] (Xenopus tropicalis)

bPSMB3 [cytosol] (Bos taurus)

psmb3 [cytosol] (Danio rerio)

psmB3 [cytosol] (Dictyostelium discoideum)

pbs-3 [cytosol] (Caenorhabditis elegans)

Prosbeta3 [cytosol] (Drosophila melanogaster)

Psmb3 [cytosol] (Mus musculus)

Psmb3 [cytosol] (Rattus norvegicus)

PUP3 [cytosol] (Saccharomyces cerevisiae)

PSMB3 [cytosol] (Canis familiaris)

PSMB3 [cytosol] (Gallus gallus)

PSMB3 [cytosol] (Plasmodium falciparum)

PSMB3 [cytosol] (Sus scrofa)

pup3 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002786.2

OpenTargets

ENSG00000277791

GeneCards

P49720

HPA

ENSG00000277791-PSMB3

Ensembl

ENSP00000483688, ENSG00000277791, ENSP00000483956, ENSG00000275903, ENST00000619951, ENST00000619426

PRO

P49720

Pharos - Targets

P49720

PDB

5VFR, 7W37, 5LEZ, 8CVS, 8QYN, 5LF1, 5VFS, 5VFQ, 8QYO, 7W3G, 5LEY, 6R70, 5LF0, 7W3J, 7W39, 6AVO, 7NHT, 5VFU, 8QYL, 8CVT, 8QYM, 7W38, 5VFT, 6E5B, 6MSH, 7W3M, 7NAN, 5T0H, 6XMJ, 7W3K, 7W3F, 7NAQ, 6MSK, 5T0J, 8QYS, 6MSJ, 7W3C, 7NAP, 5T0I, 7NAO, 7W3H, 6MSB, 8UD9, 5A0Q, 6WJN, 5LF3, 8CVR, 7QXX, 7B12, 4R67, 7QY7, 5LF4, 6MSE, 7V5M, 7QXN, 5LF6, 5LN3, 7QYB, 8CXB, 7QYA, 5L4G, 7W3I, 6KWY, 5LE5, 7V5G, 6MSD, 7AWE, 7PG9, 5T0G, 7QXU, 5T0C, 6MSG, 7W3A, 6RGQ, 5M32, 6REY, 7QXP, 5LF7, 6WJD, 5VFP, 5LEX, 5GJQ, 7QXW, 4R3O, 5VFO, 5GJR, 8BZL, 7W3B, 8QZ9, 7LXV

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.862	14
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.85	9
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.804	7
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.804	6
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.793	7
UniProt:P25787 PSMA2	5	PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.788	9
UniProt:O14818 PSMA7	2	PSMA7 [nucleoplasm] (R-HSA-174351) PSMA7 [cytosol] (R-HSA-68736)	0.768	7
UniProt:P28074 PSMB5	4	PSMB5(1-59) [cytosol] (R-HSA-9908134) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5 [nucleoplasm] (R-HSA-174344) PSMB5 [cytosol] (R-HSA-68753)	0.745	6
UniProt:Q15008 PSMD6	5	PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [cytosol] (R-HSA-68804)	0.744	5
UniProt:Q99436 PSMB7	7	PSMB7(1-43) [cytosol] (R-HSA-9908129) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.738	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.725	4
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.718	6
UniProt:P40306 PSMB10	3	pro-PSMB10 [cytosol] (R-HSA-9908123) PSMB10 [cytosol] (R-HSA-68741) PSMB10(1-39) [cytosol] (R-HSA-9908142)	0.659	5
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.643	5
UniProt:Q9GZU8 PIP30			0.643	4
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.643	4
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.643	5
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.643	4
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.643	5
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.643	4
UniProt:O43242 PSMD3	5	PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.643	4
UniProt:P28065 PSMB9	3	PSMB9(1-20) [cytosol] (R-HSA-9908132) PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136)	0.643	6
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.643	4
UniProt:Q9NW38 FANCL	2	FANCL [nucleoplasm] (R-HSA-419520) FANCL [cytosol] (R-HSA-420789)	0.556	3
UniProt:Q8N4Y2-3 CRACR2B			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P28070 PSMB4	4	PSMB4(1-45) [cytosol] (R-HSA-9908122) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4 [nucleoplasm] (R-HSA-174343) PSMB4 [cytosol] (R-HSA-68750)	0.527	4
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	4
UniProt:Q53H80 AKIR2			0.527	2
UniProt:O95456 PSMG1	1	PSMG1 [cytosol] (R-HSA-9908050)	0.527	4
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.527	3
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.527	3
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	4
UniProt:Q969U7 PSMG2	1	PSMG2 [cytosol] (R-HSA-9908053)	0.527	4
UniProt:Q9BT73 PSMG3	1	PSMG3 [cytosol] (R-HSA-9908033)	0.527	3
UniProt:Q9NX31 OSER1			0.527	3
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.527	4
UniProt:P28066 PSMA5	5	PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [cytosol] (R-HSA-68732)	0.527	4
UniProt:Q9P0P0 RNF181	1	RNF181 [cytoplasm] (R-HSA-8939317)	0.527	3
UniProt:P25789 PSMA4	2	PSMA4 [nucleoplasm] (R-HSA-174324) PSMA4 [cytosol] (R-HSA-68730)	0.527	4
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.527	2
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.527	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.527	2
UniProt:P28072 PSMB6	4	PSMB6(1-34) [cytosol] (R-HSA-9908141) pro-PSMB6 [cytosol] (R-HSA-9908130) PSMB6 [nucleoplasm] (R-HSA-174342) PSMB6 [cytosol] (R-HSA-68756)	0.527	4
UniProt:Q9UNM6 PSMD13	5	PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.527	3
UniProt:P48556 PSMD8	2	PSMD8 [nucleoplasm] (R-HSA-174318) PSMD8 [cytosol] (R-HSA-68808)	0.527	3
UniProt:Q5JS54 PSMG4	1	PSMG4 [cytosol] (R-HSA-9908036)	0.527	3
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.527	3

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