Reactome | PSMC2 [cytosol]

PSMC2 [cytosol]

Stable Identifier

R-HSA-68771

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

26S protease regulatory subunit 7, MSS1 protein, 26S proteasome AAA-ATPase subunit RPT1

Locations in the PathwayBrowser for interactor UniProt:Q9UQE7 SMC3

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External Reference Information

External Reference

UniProt:P35998 PSMC2

Gene Names

PSMC2, MSS1

Chain

initiator methionine:, chain:2-433

Reference Genes

BioGPS Gene:5701 PSMC2

COSMIC (genes):PSMC2 PSMC2

CTD Gene:5701 PSMC2

dbSNP Gene:5701 PSMC2

ENSEMBL:ENSG00000161057 PSMC2

HGNC:9548 PSMC2

KEGG:hsa:5701 PSMC2

Monarch:5701 PSMC2

NCBI Gene:5701 PSMC2

OMIM:154365 PSMC2

UCSC:P35998 PSMC2

Reference Transcript

Other Identifiers

11715901_a_at

11758736_at

11760946_at

17049965

201067_PM_at

201067_at

201068_PM_s_at

201068_s_at

238020_PM_at

238020_at

2642700

2642708

2642709

3017189

3017207

3017208

3017209

3017213

3017214

3017216

3017217

3017218

3017219

3017223

3017224

3017225

3017226

3017227

3017228

3017230

3017231

3017233

3017234

3017235

3017236

3017237

3017238

3017239

35353_at

47823_r_at

51032_at

5701

8135250

A_21_P0000155

A_23_P304287

D11094_at

GE550496

GE61412

GO:0000502

GO:0000932

GO:0001649

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006511

GO:0008540

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030154

GO:0030163

GO:0034774

GO:0036402

GO:0036464

GO:0043161

GO:0043226

GO:0140657

GO:1901800

GO:1904813

HMNXSV003047590

Hs.68467.0.S1_3p_at

ILMN_1768784

PH_hs_0003882

PH_hs_0040205

TC07000673.hg

g4506208_3p_a_at

Participates

as an input of

PSMC2 binds PSMC1 (Homo sapiens)

as a component of

PSMC2:PSMC1 [cytosol] (Homo sapiens)

Other forms of this molecule

PSMC2 [nucleoplasm]

PSMC2 [secretory granule lumen]

PSMC2 [extracellular region]

PSMC2 [ficolin-1-rich granule lumen]

Inferred To

psmc2 [cytosol] (Danio rerio)

psmc2 [cytosol] (Xenopus tropicalis)

PSMC2 [cytosol] (Bos taurus)

PSMC2 [cytosol] (Caenorhabditis elegans)

PSMC2 [cytosol] (Canis familiaris)

PSMC2 [cytosol] (Dictyostelium discoideum)

PSMC2 [cytosol] (Gallus gallus)

PSMC2 [cytosol] (Mus musculus)

PSMC2 [cytosol] (Plasmodium falciparum)

PSMC2 [cytosol] (Rattus norvegicus)

PSMC2 [cytosol] (Saccharomyces cerevisiae)

PSMC2 [cytosol] (Schizosaccharomyces pombe)

PSMC2 [cytosol] (Sus scrofa)

Rpt1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001191382.1, NP_002794.1

OpenTargets

ENSG00000161057

ENSEMBL

ENST00000679250, ENST00000435765, ENST00000292644, ENSP00000502939, ENSP00000391211, ENSP00000504608, ENSP00000503179, ENST00000679205, ENSP00000292644, ENSP00000503663, ENST00000678493, ENST00000679341

HPA

ENSG00000161057-PSMC2

PRO

P35998

Pharos - Targets

P35998

GlyGen

P35998

PDB

5VHH, 5VFQ, 7QXU, 7W3G, 5VFP, 6MSK, 5VFS, 5L4G, 5VHI, 8CVT, 5GJQ, 6MSE, 7QXP, 7QXN, 5VHO, 7QYB, 5T0G, 7W38, 5LN3, 7W37, 7W3I, 6MSH, 7W3K, 5T0J, 7W3M, 6WJN, 7QXW, 5VHM, 6MSG, 5M32, 6WJD, 5VFR, 5VFU, 7W3B, 7W3H, 6MSJ, 5VHF, 7W3J, 5VFT, 5VHJ, 5VHR, 5VHQ, 5T0C, 6MSD, 7W3C, 7QXX, 7QY7, 7QYA, 5VHP, 5T0H, 5VGZ, 7W3A, 6MSB, 7W39, 5VHS, 7W3F, 5T0I, 5VHN, 5GJR

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.96	25
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.864	14
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.857	9
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.825	6
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.8	8
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	7
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.744	5
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.744	6
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.725	6
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.671	10
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.669	3
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.669	5
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	5
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.643	5
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.643	5
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	16
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.564	3
UniProt:P54727 RAD23B	2	RAD23B [cytosol] (R-HSA-8850589) RAD23B [nucleoplasm] (R-HSA-62590)	0.564	2
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q9BVL2 NUP58			0.556	3
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.527	2
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.527	2
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	2
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.527	2
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.527	3
UniProt:O60216 RAD21	14	RAD21 [nucleoplasm] (R-HSA-163042) RAD21 [chromosome, centromeric region] (R-HSA-2466012) RAD21 [chromosome] (R-HSA-1638775) p-S454-RAD21 [chromosome, centromeric region] (R-HSA-2485163) p-S454-RAD21 [cytosol] (R-HSA-2500310) p-S454-RAD21 [chromosome] (R-HSA-2485164) RAD21(1-172) [chromosome, centromeric region] (R-HSA-2467793) p-S454-RAD21(451-631) [chromosome, centromeric region] (R-HSA-2467790) RAD21(173-450) [chromosome, centromeric region] (R-HSA-2500296) RAD21(1-172) [cytosol] (R-HSA-2484901) RAD21(173-450) [cytosol] (R-HSA-2500308) p-S454-RAD21(451-631) [cytosol] (R-HSA-2500309) RAD21 [cytosol] (R-HSA-2484795) monoSUMO1-K-RAD21 [nucleoplasm] (R-HSA-3108183)	0.527	2
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.527	2
UniProt:Q9UQE7 SMC3	6	SMC3 [cytosol] (R-HSA-2545223) 2xAcK-SMC3 [cytosol] (R-HSA-2484792) 2xAcK-SMC3 [chromosome] (R-HSA-2468146) 2xAcK-SMC3 [chromosome, centromeric region] (R-HSA-2468148) 2xAcK-SMC3 [nucleoplasm] (R-HSA-2468050) SMC3 [nucleoplasm] (R-HSA-163009)	0.527	2
UniProt:Q14683 SMC1A	4	SMC1A [cytosol] (R-HSA-2484798) SMC1A [chromosome] (R-HSA-1638774) SMC1A [chromosome, centromeric region] (R-HSA-2466015) SMC1A [nucleoplasm] (R-HSA-64561)	0.527	2
UniProt:Q53HC0 CCD92			0.527	3
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.488	2

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