Reactome | PSMC3 [cytosol]

PSMC3 [cytosol]

Stable Identifier

R-HSA-68774

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

26S protease regulatory subunit 6A, TAT-binding protein 1, TBP-1, Proteasome subunit P50, 26S proteasome AAA-ATPase subunit RPT5

Locations in the PathwayBrowser for interactor UniProt:P03255-1

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External Reference Information

External Reference

UniProt:P17980 PSMC3

Gene Names

PSMC3, TBP1

Chain

chain:1-439

Reference Genes

BioGPS Gene:5702 PSMC3

COSMIC (genes):PSMC3 PSMC3

CTD Gene:5702 PSMC3

dbSNP Gene:5702 PSMC3

ENSEMBL:ENSG00000165916 PSMC3

HGNC:9549 PSMC3

KEGG:hsa:5702 PSMC3

Monarch:5702 PSMC3

NCBI Gene:5702 PSMC3

OMIM:186852 PSMC3

UCSC:P17980 PSMC3

Reference Transcript

RefSeq:NM_002804.4 PSMC3

Other Identifiers

11715815_a_at

16738023

201267_PM_s_at

201267_s_at

3164161

3164167

3164172

3164173

3372212

3372213

3372215

3372216

3372217

3372218

3372219

3372220

3372221

3372222

3372223

3372224

3372225

3372226

3372227

3372228

3372229

3372230

3372234

5702

592_at

7947867

A_23_P104607

GE61288

GO:0000502

GO:0000932

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0008540

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0034774

GO:0036402

GO:0042802

GO:0043161

GO:0043226

GO:0043921

GO:0045944

GO:0140657

GO:1901800

GO:1904813

HMNXSV003034992

Hs.250758.0.S1_3p_s_at

ILMN_1809010

M34079_at

PH_hs_0028031

TC11001738.hg

Participates

as an input of

PSMC3 binds PSMC6 (Homo sapiens)

as a component of

PSMC3:PSMC6 [cytosol] (Homo sapiens)

Other forms of this molecule

PSMC3 [nucleoplasm]

PSMC3 [ficolin-1-rich granule lumen]

PSMC3 [extracellular region]

PSMC3 [secretory granule lumen]

Inferred To

psmC3 [cytosol] (Dictyostelium discoideum)

Ghost homologue of PSMC3 [cytosol] (Danio rerio)

RPT5 [cytosol] (Saccharomyces cerevisiae)

Psmc3 [cytosol] (Mus musculus)

Psmc3 [cytosol] (Rattus norvegicus)

Rpt5 [cytosol] (Drosophila melanogaster)

tbp1 [cytosol] (Schizosaccharomyces pombe)

psmc3 [cytosol] (Xenopus tropicalis)

rpt-5 [cytosol] (Caenorhabditis elegans)

PSMC3 [cytosol] (Bos taurus)

PSMC3 [cytosol] (Canis familiaris)

PSMC3 [cytosol] (Gallus gallus)

PSMC3 [cytosol] (Plasmodium falciparum)

PSMC3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_002795.2

OpenTargets

ENSG00000165916

ENSEMBL

ENSP00000298852, ENSP00000481029, ENST00000619920, ENST00000298852, ENSG00000165916

GeneCards

PSMC3

HPA

ENSG00000165916-PSMC3

PRO

P17980

Pharos - Targets

P17980

GlyGen

P17980

PDB

9E8G, 5VHP, 9E8I, 9E8K, 8USC, 5VHQ, 5T0C, 5VHJ, 5VHR, 7QYA, 5VFQ, 7QXU, 7W3G, 7W3I, 6MSH, 8JRI, 7QXW, 6MSG, 6WJN, 6WJD, 9E8O, 7W37, 5VFS, 7W38, 8JRT, 9E8Q, 6MSK, 5LN3, 5VHN, 5M32, 5T0G, 5T0J, 7W3M, 7W3K, 6MSE, 5GJQ, 7QXN, 7QXP, 5VHH, 5VHO, 9E8H, 9E8J, 8CVT, 5L4G, 5VHI, 7QYB, 8USB, 7W3H, 5VFR, 7W3J, 7W3B, 5VHF, 7W3A, 5VFU, 6MSB, 5VFP, 5VGZ, 5GJR, 7W39, 5VFT, 6MSJ, 5VHM, 5T0H, 8JTI, 5VHS, 5T0I, 9E8N, 9E8L, 7W3F, 7W3C, 7QXX, 6MSD, 7QY7

Interactors (68)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.953	21
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.942	22
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.837	7
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.802	7
UniProt:Q9BUZ4 TRAF4			0.8	7
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.788	7
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.758	10
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.744	4
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.744	4
UniProt:Q9NVF7 FBX28			0.742	6
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.725	6
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [secretory granule lumen] (R-HSA-6800994)	0.725	6
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.725	5
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.725	5
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.669	5
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [secretory granule lumen] (R-HSA-6800983)	0.669	4
UniProt:P54253 ATX1			0.666	7
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.666	5
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [secretory granule lumen] (R-HSA-6800917)	0.666	4
UniProt:Q9UPU7 TBD2B			0.643	3
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.643	4
UniProt:Q9ULM3 YEATS2	1	YEATS2 [nucleoplasm] (R-HSA-3321976)	0.643	4
UniProt:Q6MZP7 LIN54	1	LIN54 [nucleoplasm] (R-HSA-389103)	0.643	4
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [secretory granule lumen] (R-HSA-6801008)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	15
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.564	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:A8K2R3 A8K2R3			0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	6
UniProt:P12532 CKMT1A	1	CKMT1A [mitochondrial inner membrane] (R-HSA-200361)	0.556	3
UniProt:Q9Y2J4-4 AMOTL2			0.556	5
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	6
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.556	3
UniProt:P00441 SOD1	5	2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [extracellular region] (R-HSA-350705)	0.556	3
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.556	3
UniProt:O14561 NDUFAB1	3	NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925) octanoyl-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-9857608) Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586)	0.556	6
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.547	2
UniProt:Q8NE28 STKL1			0.527	3
UniProt:Q8IWI9 MGA	1	MGA [nucleoplasm] (R-HSA-8953093)	0.527	3
UniProt:Q8TDP1 RNH2C			0.527	2
UniProt:Q53HC0 CCD92			0.527	3
UniProt:P62829 RPL23	1	RPL23 [cytosol] (R-HSA-72430)	0.527	3
UniProt:P41214 EIF2D			0.527	2
UniProt:Q8WW01 TSEN15	1	TSEN15 [nucleoplasm] (R-HSA-5696772)	0.527	2
UniProt:Q9BU70 TRMO			0.527	2
UniProt:Q5JXX7 TMM31			0.527	3
UniProt:P41250 GARS1	2	GARS [mitochondrial matrix] (R-HSA-379650) GARS(55-739) [cytosol] (R-HSA-379574)	0.527	3
UniProt:Q96CP2 FWCH2			0.527	2
UniProt:Q9BVQ7 AFG2B			0.527	2
UniProt:Q86XZ4 SPAS2			0.527	2
UniProt:Q6P1L5 F117B			0.527	2
UniProt:P35269 GTF2F1	1	GTF2F1 [nucleoplasm] (R-HSA-65565)	0.527	2
UniProt:Q9BQD3 KXDL1			0.527	2
UniProt:Q5T3J3 LRIF1			0.527	3
UniProt:Q9P0K7 RAI14			0.527	4
UniProt:Q13608 PEX6	1	PEX6 [cytosol] (R-HSA-9033104)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.527	2
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.527	2
UniProt:Q04323 UBXN1	2	UBXN1 [cytosol] (R-HSA-8850588) UBXN1 [nucleoplasm] (R-HSA-9707052)	0.527	3
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943)	0.527	2
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873)	0.527	3
UniProt:P28065 PSMB9	3	PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [secretory granule lumen] (R-HSA-6800926)	0.527	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.527	3
UniProt:P03255-1			0.524	2

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