Reactome | PSMD8 [cytosol]

PSMD8 [cytosol]

Stable Identifier

R-HSA-68808

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

26S proteasome non-ATPase regulatory subunit 8, 26S proteasome regulatory subunit S14, p31, Rpn12

Locations in the PathwayBrowser for interactor UniProt:P30041 PRDX6

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External Reference Information

External Reference

UniProt:P48556 PSMD8

Gene Names

PSMD8

Chain

chain:1-350

Reference Genes

BioGPS Gene:5714 PSMD8

COSMIC (genes):PSMD8 PSMD8

CTD Gene:5714 PSMD8

dbSNP Gene:5714 PSMD8

ENSEMBL:ENSG00000099341 PSMD8

HGNC:9566 PSMD8

KEGG:hsa:5714 PSMD8

Monarch:5714 PSMD8

NCBI Gene:5714 PSMD8

OMIM:617844 PSMD8

UCSC:P48556 PSMD8

Reference Transcript

RefSeq:NM_002812.4 PSMD8

Other Identifiers

11732145_a_at

11732146_x_at

11761486_a_at

1312_at

16861704

200820_PM_at

200820_at

2436669

32584_at

3832384

3832385

3832386

3832387

3832388

3832389

3832390

3832391

3832392

3832393

3832394

3832395

3832396

3832397

3832398

3832399

3832400

3832401

5714

8028380

A_14_P131224

A_23_P67466

D38047_at

GE57181

GO:0000502

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0006508

GO:0008541

GO:0022624

GO:0030163

GO:0043161

GO:0043226

HMNXSV003019807

ILMN_1733256

PH_hs_0004526

PH_hs_0031341

TC19000527.hg

g4506232_3p_at

Participates

as an input of

Formation of the 19S regulatory particle lid (Homo sapiens)

as a component of

19S RP lid [cytosol] (Homo sapiens)

Other forms of this molecule

PSMD8 [nucleoplasm]

Inferred To

RPN12 [cytosol] (Saccharomyces cerevisiae)

PSMD8 [cytosol] (Bos taurus)

PSMD8 [cytosol] (Canis familiaris)

PSMD8 [cytosol] (Plasmodium falciparum)

PSMD8 [cytosol] (Sus scrofa)

Psmd8 [cytosol] (Mus musculus)

Psmd8 [cytosol] (Rattus norvegicus)

psmD8-2 [cytosol] (Dictyostelium discoideum)

psmd8 [cytosol] (Danio rerio)

psmd8 [cytosol] (Xenopus tropicalis)

rpn-12 [cytosol] (Caenorhabditis elegans)

rpn12 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of PSMD8 [cytosol] (Gallus gallus)

Rpn12 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_002803.2

OpenTargets

ENSG00000099341

ENSEMBL

ENSP00000215071, ENST00000215071

HPA

ENSG00000099341-PSMD8

PRO

P48556

Pharos - Targets

P48556

GlyGen

P48556

PDB

7QXX, 7QY7, 7W37, 7QYB, 7W38, 5VHH, 5T0J, 6MSH, 5VGZ, 5VHS, 5GJR, 6MSG, 6WJN, 7W3C, 7W3F, 5VFR, 5LN3, 5VFU, 5T0G, 6MSK, 5VHF, 5M32, 7W3J, 7W3H, 5VFT, 7W3K, 7W3M, 8CVT, 6MSD, 7QXN, 7QXP, 5GJQ, 7W39, 5VHI, 7QYA, 7W3I, 7W3A, 7W3G, 5T0I, 6MSB, 5L4K, 7QXW, 5T0C, 5VFQ, 5T0H, 6MSJ, 5VFP, 7W3B, 6WJD, 7QXU, 5VFS

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.725	5
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	4
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.643	4
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.643	4
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.564	2
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.564	3
UniProt:Q92529 SHC3	2	SHC3 [cytosol] (R-HSA-3006448) p-Y-SHC3 [cytosol] (R-HSA-3009043)	0.556	3
UniProt:P30041 PRDX6	3	PRDX6 [cytosol] (R-HSA-3343670) PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [azurophil granule lumen] (R-HSA-6798744)	0.556	3
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:Q53HC0 CCD92			0.527	3
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.527	2
UniProt:O14641 DVL2	5	DVL2 [cytosol] (R-HSA-201694) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.527	2
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.527	3
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	2
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.527	2
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416)	0.527	3
UniProt:Q8N3I7 BBS5	1	BBS5 [cytosol] (R-HSA-5617633)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4

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