TNFAIP3 (A20) deubiquitinates RIP2

Stable Identifier
R-HSA-688136
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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TNFAIP3 (A20) deubiquitinates RIP2
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The deubiquitinase A20 is a negative feedback regulator of inflammatory responses, induced by NFkappaB activation (Krikos et al. 1992) and NOD stimulation (Masumoto et al. 2006). A20 can deubiquitinate RIP2 and restricts NOD2 induced signals (Hitosumatsu et al. 2008).

Literature References
PubMed ID Title Journal Year
18079694 A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

Hasegawa, M, Nakano, H, Lucas, PC, Nunez, G, Fujimoto, Y, Inohara, N, Fukase, K

EMBO J 2008
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Catalyst Activity

Lys63-specific deubiquitinase activity of TNFAIP3 [cytosol]

Physical Entity
TNFAIP3 [cytosol] (Homo sapiens)
Activity
Lys63-specific deubiquitinase activity (GO:0061578)
Orthologous Events
TNFAIP3 (A20) deubiquitinates RIP2 (Bos taurus)
TNFAIP3 (A20) deubiquitinates RIP2 (Canis familiaris)
TNFAIP3 (A20) deubiquitinates RIP2 (Danio rerio)
TNFAIP3 (A20) deubiquitinates RIP2 (Mus musculus)
TNFAIP3 (A20) deubiquitinates RIP2 (Rattus norvegicus)
Authored
Jupe, S  (2010-04-22)
Reviewed
Kufer, TA  (2011-04-28)
Rittinger, K  (2011-06-06)
Wong, E  (2011-06-06)
Created
Jupe, S  (2010-05-06)
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