Reactome | PSME2 [cytosol]

PSME2 [cytosol]

Stable Identifier

R-HSA-68814

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proteasome activator complex subunit 2, Proteasome activator 28-beta subunit, PA28beta, PA28b, Activator of multicatalytic protease subunit 2, 11S regulator complex beta subunit, REG-beta

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UL46 PSME2

Gene Names

PSME2

Chain

initiator methionine:, chain:2-239

Reference Genes

BioGPS Gene:5721 PSME2

COSMIC (genes):PSME2 PSME2

CTD Gene:5721 PSME2

dbSNP Gene:5721 PSME2

ENSEMBL:ENSG00000100911 PSME2

ENSEMBL_homo_sapiens_GENE:ENSG00000100911.16 PSME2

ENSEMBL_homo_sapiens_GENE:ENSG00000284889.2 PSME2

HGNC:9569 PSME2

KEGG Gene (Homo sapiens):5721 PSME2

Monarch:5721 PSME2

NCBI Gene:5721 PSME2

OMIM:602161 PSME2

UCSC:Q9UL46 PSME2

Reference Transcript

RefSeq:NM_002818.2 PSME2

Other Identifiers

1184_at

16791059

201762_PM_s_at

201762_s_at

2749686

2749687

2821648

3238435

3489180

3489181

3489182

3557812

3557813

3557815

3557817

3557819

3557820

3557823

3557825

3557827

3557829

3557832

3557834

41171_at

5721

7978123

A_23_P65427

D45248_at

GE81197

GO:0000278

GO:0000502

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0008537

GO:0016020

GO:0030163

GO:0042802

GO:0043226

GO:0061133

GO:0061136

GO:0070062

GO:0098772

GO:2000045

HMNXSV003006858

HMNXSV003016126

TC14000968.hg

g4506236_3p_a_at

Participates

as an input of

Formation of the PA28-alpha-beta regulatory particle (Homo sapiens)

as a component of

PA28-alpha-beta heteroheptamer [cytosol] (Homo sapiens)

Other forms of this molecule

PSME2 [nucleoplasm]

Inferred To

psme-3 [cytosol] (Caenorhabditis elegans)

psmE3 [cytosol] (Dictyostelium discoideum)

psme2 [cytosol] (Danio rerio)

psme2 [cytosol] (Xenopus tropicalis)

Psme2 [cytosol] (Mus musculus)

Psme2 [cytosol] (Rattus norvegicus)

PSME2 [cytosol] (Bos taurus)

PSME2 [cytosol] (Canis familiaris)

PSME2 [cytosol] (Plasmodium falciparum)

PSME2 [cytosol] (Sus scrofa)

REG [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_002809.2

OpenTargets

ENSG00000100911

GeneCards

Q9UL46

HPA

ENSG00000100911-PSME2

Ensembl

ENST00000216802, ENST00000645325, ENSP00000216802, ENSP00000495790, ENSG00000284889, ENSG00000100911

PRO

Q9UL46

Pharos - Targets

Q9UL46

PDB

8CXB, 7NAP, 7NAO, 7DRW, 7DR6

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06323 PSME1	1	PSME1 [cytosol] (R-HSA-68812)	0.801	10
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.718	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	13
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.666	5
UniProt:P28065 PSMB9	3	PSMB9(1-20) [cytosol] (R-HSA-9908132) PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136)	0.643	5
UniProt:P20618 PSMB1	7	PSMB1(1-28) [cytosol] (R-HSA-9908143) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [cytosol] (R-HSA-68738)	0.643	5
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.643	4
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.629	8
UniProt:Q9BVJ7 DUS23			0.556	3
UniProt:Q9BZL1 UBL5	1	UBL5 [nucleoplasm] (R-HSA-9770255)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:P28070 PSMB4	4	PSMB4(1-45) [cytosol] (R-HSA-9908122) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4 [nucleoplasm] (R-HSA-174343) PSMB4 [cytosol] (R-HSA-68750)	0.527	3
UniProt:P40313 CTRL			0.527	2
UniProt:Q99436 PSMB7	7	PSMB7(1-43) [cytosol] (R-HSA-9908129) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.527	3
UniProt:Q8TCT7 SPPL2B	1	SPPL2B [plasma membrane] (R-HSA-8863116)	0.527	2
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.527	4
UniProt:Q9BY78 RNF26			0.527	2
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.527	2
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:P25787 PSMA2	5	PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.527	4
UniProt:P28066 PSMA5	5	PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [cytosol] (R-HSA-68732)	0.527	4

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