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CCNB2 [cytosol]
Stable Identifier
R-HSA-68897
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
G2/mitotic-specific cyclin B2
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA replication checkpoint (Homo sapiens)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)
CCNB:CDK1 [cytosol] (Homo sapiens)
CCNB [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
CCNB:p-T14-CDK1 [cytosol] (Homo sapiens)
CCNB [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
CDK1 phosphorylates LBR (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Condensation of Prometaphase Chromosomes (Homo sapiens)
CDK1 phosphorylates condensin I (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Golgi Cisternae Pericentriolar Stack Reorganization (Homo sapiens)
Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Homo sapiens)
CDK1:CCNB phosphorylates NEK9 (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)
CDK1 phosphorylates NUP98 (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B (Homo sapiens)
CCNB1,CCNB2:p-T14,Y15,T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T14,Y15,T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Formation of Cyclin B:Cdc2 complexes (Homo sapiens)
CCNB [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
CCNB:CDK1 [cytosol] (Homo sapiens)
CCNB [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)
CCNB:CDK1 [cytosol] (Homo sapiens)
CCNB [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
CCNB:p-T14-CDK1 [cytosol] (Homo sapiens)
CCNB [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
FOXM1 stimulates CCNB2 transcription (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
CDK1 phosphorylates BORA (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
The role of GTSE1 in G2/M progression after G2 checkpoint (Homo sapiens)
Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends (Homo sapiens)
Mitotic kinase [cytosol] (Homo sapiens)
CCNB1,CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95067 CCNB2
Gene Names
CCNB2
Chain
chain:1-398
Reference Genes
BioGPS Gene:9133 CCNB2
COSMIC (genes):CCNB2 CCNB2
CTD Gene:9133 CCNB2
dbSNP Gene:9133 CCNB2
ENSEMBL:ENSG00000157456 CCNB2
HGNC:1580 CCNB2
KEGG:hsa:9133 CCNB2
Monarch:9133 CCNB2
NCBI Gene:9133 CCNB2
OMIM:602755 CCNB2
UCSC:O95067 CCNB2
Reference Transcript
RefSeq:NM_004701.3 CCNB2
Other Identifiers
11716793_a_at
16801557
202705_PM_at
202705_at
32263_at
3595980
3595981
3595983
3595984
3595985
3595986
3595988
3595989
3595990
3595991
3595992
3595994
3595995
3595996
3595997
3595998
3596003
3596004
3596005
7983969
9133
A_14_P100596
A_23_P65757
GE78964
GO:0000307
GO:0001701
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0007010
GO:0007057
GO:0008315
GO:0015630
GO:0016020
GO:0016538
GO:0022414
GO:0040008
GO:0043029
GO:0043226
GO:0044772
GO:0045296
GO:0048538
GO:0048856
GO:0051301
GO:0098772
HMNXSV003019319
ILMN_1801939
PH_hs_0011508
TC15000449.hg
g10938017_3p_at
Participates
as an output of
FOXM1 stimulates CCNB2 transcription (Homo sapiens)
as a member of
CCNB [cytosol] (Homo sapiens)
as a component of
CCNB2:p-T161-CDK1 [cytosol] (Homo sapiens)
CCNB2:p-T14,Y15,T161-CDK1 [cytosol] (Homo sapiens)
Inferred To
Ccnb2 [cytosol]
(Mus musculus)
Ccnb2 [cytosol]
(Rattus norvegicus)
Homologues of CCNB2 [cytosol]
(Rattus norvegicus)
CycB [cytosol]
(Drosophila melanogaster)
ccnb2 [cytosol]
(Danio rerio)
ccnb2 [cytosol]
(Xenopus tropicalis)
cyb-1 [cytosol]
(Caenorhabditis elegans)
Ccnb2-ps2 [cytosol]
(Rattus norvegicus)
CCNB2 [cytosol]
(Bos taurus)
CCNB2 [cytosol]
(Canis familiaris)
CCNB2 [cytosol]
(Gallus gallus)
CCNB2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_004692.1
ENSEMBL
ENSP00000288207
,
ENST00000288207
OpenTargets
ENSG00000157456
HPA
ENSG00000157456-CCNB2
PRO
O95067
Pharos - Targets
O95067
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06493 CDK1
11
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
CDK1 [cytosol]
(R-HSA-170075)
CDK1 [nucleoplasm]
(R-HSA-68889)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
0.837
10
UniProt:P24941 CDK2
5
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
CDK2 [nucleoplasm]
(R-HSA-68365)
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
0.822
6
UniProt:Q99640 PKMYT1
3
PKMYT1 [cytosol]
(R-HSA-157457)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [nucleoplasm]
(R-HSA-74386)
0.725
5
UniProt:P21333 FLNA
3
FLNA [extracellular region]
(R-HSA-350712)
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [cytosol]
(R-HSA-210019)
0.679
8
UniProt:P46527 CDKN1B
8
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
CDKN1B [cytosol]
(R-HSA-198622)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.669
4
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.623
4
UniProt:P38936 CDKN1A
5
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
CDKN1A [cytosol]
(R-HSA-182512)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.59
2
UniProt:Q15154 PCM1
1
PCM1 [cytosol]
(R-HSA-380308)
0.569
4
UniProt:O95292 VAPB
2
VAPB [Golgi membrane]
(R-HSA-9715115)
VAPB [endoplasmic reticulum membrane]
(R-HSA-429718)
0.527
3
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.527
2
UniProt:P33552 CKS2
0.527
3
UniProt:Q9H3K2 GHITM
0.527
2
UniProt:Q8IWB7 WDFY1
0.527
2
UniProt:A2RU67 F234B
0.527
3
UniProt:P24387 CRHBP
1
CRHBP [extracellular region]
(R-HSA-8937598)
0.527
2
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