Reactome | TNFAIP3 [cytosol]

TNFAIP3 [cytosol]

Stable Identifier

R-HSA-688989

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tumor necrosis factor alpha-induced protein 3, TNAP3_HUMAN, Zinc-finger protein A20, A20

Locations in the PathwayBrowser for interactor UniProt:Q8NFZ5 TNIP2

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External Reference Information

External Reference

UniProt:P21580 TNFAIP3

Gene Names

TNFAIP3, OTUD7C

Chain

initiator methionine:, chain:2-790, chain:2-439, chain:440-790

Reference Genes

BioGPS Gene:7128 TNFAIP3

COSMIC (genes):TNFAIP3 TNFAIP3

CTD Gene:7128 TNFAIP3

dbSNP Gene:7128 TNFAIP3

ENSEMBL:ENSG00000118503 TNFAIP3

HGNC:11896 TNFAIP3

KEGG:hsa:7128 TNFAIP3

Monarch:7128 TNFAIP3

NCBI Gene:7128 TNFAIP3

OMIM:191163 TNFAIP3

UCSC:P21580 TNFAIP3

Reference Transcript

Other Identifiers

11718939_s_at

11718940_a_at

17012946

202643_PM_s_at

202643_s_at

202644_PM_s_at

202644_s_at

2885055

2927508

2927509

2927510

2927511

2927513

2927514

2927515

2927516

2927517

2927518

2927519

2927520

2927521

2927522

2927523

2927524

2927526

2927527

2927528

2927529

2927530

2927531

2927532

2927533

595_at

7128

8122265

A_14_P201749

A_24_P157926

A_24_P166527

GE61999

GO:0001922

GO:0002020

GO:0002237

GO:0002376

GO:0002634

GO:0002677

GO:0003677

GO:0003824

GO:0004842

GO:0004843

GO:0005515

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005829

GO:0006355

GO:0006508

GO:0006915

GO:0006954

GO:0007010

GO:0008234

GO:0008270

GO:0010803

GO:0012501

GO:0016477

GO:0016579

GO:0016740

GO:0016787

GO:0019900

GO:0030177

GO:0031397

GO:0032088

GO:0032495

GO:0032691

GO:0032703

GO:0032715

GO:0032720

GO:0034136

GO:0034140

GO:0034144

GO:0034148

GO:0035523

GO:0035871

GO:0035872

GO:0042802

GO:0043124

GO:0043130

GO:0043226

GO:0045732

GO:0045779

GO:0045824

GO:0046872

GO:0048662

GO:0048870

GO:0050691

GO:0050728

GO:0050869

GO:0061043

GO:0061578

GO:0070062

GO:0070301

GO:0070429

GO:0070433

GO:0070530

GO:0070536

GO:0070936

GO:0071108

GO:0071222

GO:0071947

GO:0072573

GO:0072666

GO:0090291

GO:0140096

GO:1902042

GO:1990168

GO:2000347

GO:2000349

GO:2000352

GO:2001237

HMNXSV003009318

Hs.211600.0.S1_3p_a_at

ILMN_1702691

M59465_at

PH_hs_0012275

TC06001027.hg

TC06003084.hg

g5454131_3p_a_at

Participates

as a component of

as an input of

TNIPs bind TNFAIP3 (A20) (Homo sapiens)

as a member of

Inferred To

Tnfaip3 [cytosol] (Rattus norvegicus)

trbd [cytosol] (Drosophila melanogaster)

TNFAIP3 [cytosol] (Bos taurus)

TNFAIP3 [cytosol] (Canis familiaris)

TNFAIP3 [cytosol] (Gallus gallus)

TNFAIP3 [cytosol] (Mus musculus)

TNFAIP3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006281.1, NP_001257436.1, NP_001257437.1, XP_005267176.1, XP_011534397.1

OpenTargets

ENSG00000118503

ENSEMBL

ENST00000420009, ENST00000237289, ENSP00000401562, ENSP00000237289, ENST00000421450, ENST00000612899, ENSP00000409845, ENSP00000393577, ENSP00000481570, ENST00000433680

HPA

ENSG00000118503-TNFAIP3

PRO

P21580

Pharos - Targets

P21580

GlyGen

P21580

Orphanet

TNFAIP3

PDB

3OJ3, 5V3B, 3DKB, 3VUX, 3ZJG, 3OJ4, 3VUW, 2EQF, 2EQG, 3VUY, 5LRX, 5V3P, 3ZJE, 3ZJF, 2VFJ, 3ZJD, 2EQE

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15025 TNIP1	1	TNIP1 [cytosol] (R-HSA-5690853)	0.906	12
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.888	9
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.831	10
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.813	6
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.806	7
UniProt:P36406 TRI23			0.718	6
UniProt:Q96B67 ARRD3			0.718	6
UniProt:Q8NFZ5 TNIP2	1	TNIP2 [cytosol] (R-HSA-451661)	0.688	5
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.621	4
IntAct:EBI-4399559 UBIQ			0.618	3
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.597	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.573	3
UniProt:Q9Y3C5 RNF11			0.573	2
UniProt:Q9NWF9 RNF216	1	RNF216 [cytosol] (R-HSA-936043)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q96KP6 TNIP3	1	TNIP3 [cytosol] (R-HSA-561192)	0.556	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	2
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.527	2
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.527	2
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.527	2
UniProt:Q96A37 RN166			0.527	2
UniProt:Q6ZTN6 AN13D			0.527	2
UniProt:Q96BJ3 AIDA			0.527	2
UniProt:Q9Y5E4 PCDB5			0.527	2
UniProt:Q8TBC3 SHKBP1	1	SHKBP1 [cytosol] (R-HSA-9714849)	0.527	2
UniProt:P68510 Ywhah	1	14-3-3 eta [cytosol] (R-MMU-1445091)	0.508	3
UniProt:Q14790 CASP8	8	CASP8(1-374) [cytosol] (R-HSA-3465404) CASP8(217-374) [mitochondrial outer membrane] (R-HSA-351869) CASP8(385-479) [mitochondrial outer membrane] (R-HSA-351828) CASP8(385-479) [cytosol] (R-HSA-76158) CASP8(375-384) [cytosol] (R-HSA-933460) CASP8(217-374) [cytosol] (R-HSA-75975) CASP8(1-216) [cytosol] (R-HSA-933456) CASP8(1-479) [cytosol] (R-HSA-57031)	0.499	3

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