Reactome | CCNB1 [nucleoplasm]

CCNB1 [nucleoplasm]

Stable Identifier

R-HSA-68901

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

G2/mitotic-specific cyclin B1

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - CDK1 phosphorylates RUNX2 (Homo sapiens)
        
        CCNB1:p-T161-CDK1 [nucleoplasm] (Homo sapiens)
        
        CCNB1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14635 CCNB1

Gene Names

CCNB1, CCNB

Chain

chain:1-433

Reference Genes

BioGPS Gene:891 CCNB1

COSMIC (genes):CCNB1 CCNB1

CTD Gene:891 CCNB1

dbSNP Gene:891 CCNB1

ENSEMBL:ENSG00000134057 CCNB1

ENSEMBL:ENSG00000134057.15 CCNB1

HGNC:1579 CCNB1

KEGG Gene (Homo sapiens):891 CCNB1

Monarch:891 CCNB1

NCBI Gene:891 CCNB1

OMIM:123836 CCNB1

UCSC:P14635 CCNB1

Reference Transcript

RefSeq:NM_031966.3 CCNB1

Other Identifiers

11723939_a_at

16985599

1945_at

214710_PM_s_at

214710_s_at

228729_PM_at

228729_at

2813416

2813417

2813418

2813419

2813421

2813422

2813423

2813424

2813425

2813427

2813429

2813432

2813434

2813435

2813436

2813437

34736_at

63638_at

8105828

891

A_33_P3401621

GE57886

GO:0000079

GO:0000086

GO:0000278

GO:0000922

GO:0000940

GO:0001701

GO:0005113

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006091

GO:0006468

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007080

GO:0010971

GO:0016020

GO:0016538

GO:0019901

GO:0023052

GO:0036211

GO:0043226

GO:0044389

GO:0044772

GO:0045787

GO:0045931

GO:0048146

GO:0048856

GO:0051301

GO:0051987

GO:0060090

GO:0061575

GO:0090266

GO:0097125

GO:0098772

GO:0140014

GO:1905448

HMNXSV003039343

Hs.23960.0.S1_3p_at

Hs.23960.2.S1_3p_a_at

ILMN_1712803

M25753_at

PH_hs_0002110

TC05000298.hg

TC05002418.hg

Participates

as an output of

FOXM1 stimulates CCNB1 transcription (Homo sapiens)

as a component of

Other forms of this molecule

p-4S-CCNB1 [cytosol]

p-4S-CCNB1 [nucleoplasm]

CCNB1 [cytosol]

Inferred To

CycB [nucleoplasm] (Drosophila melanogaster)

ccnb1.2 [nucleoplasm] (Xenopus tropicalis)

cyb-1 [nucleoplasm] (Caenorhabditis elegans)

CCNB1 [nucleoplasm] (Bos taurus)

CCNB1 [nucleoplasm] (Canis familiaris)

CCNB1 [nucleoplasm] (Danio rerio)

CCNB1 [nucleoplasm] (Sus scrofa)

Ccnb1 [nucleoplasm] (Mus musculus)

Ccnb1 [nucleoplasm] (Rattus norvegicus)

cyb-2.1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of CCNB1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of CCNB1 [nucleoplasm] (Canis familiaris)

cyb-2.2 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_114172.1

OpenTargets

ENSG00000134057

HPA

ENSG00000134057-CCNB1

GeneCards

P14635

ZINC - Substances

CCNB1_HUMAN

ZINC target

P14635

Ensembl

ENST00000256442, ENST00000505500, ENSG00000134057, ENSP00000424588, ENSP00000256442

PRO

P14635

Pharos - Targets

P14635

ZINC - Predictions - Purchasable

CCNB1_HUMAN

PDB

6GU2, 6GU4, 4Y72, 7NJ0, 2JGZ, 5HQ0, 6GU3, 2B9R, 4YC3, 5LQF

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.972	24
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064)	0.788	5
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.788	7
UniProt:Q99640 PKMYT1	3	PKMYT1 [cytosol] (R-HSA-157457) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [nucleoplasm] (R-HSA-74386)	0.776	6
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438)	0.669	4
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.65	3
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	4
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.59	2
UniProt:O75618-1 DEDD			0.576	3
UniProt:Q12778 FOXO1	5	p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942)	0.571	2
UniProt:Q9NPC3 CIP1			0.527	2
UniProt:P33552 CKS2			0.527	2
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.527	2
UniProt:Q13635 PTCH1	4	PTCH1 [plasma membrane] (R-HSA-445133) PTCH1 [ciliary membrane] (R-HSA-5610415) ub-PTCH1 [endocytic vesicle membrane] (R-HSA-5632520) ub-PTCH1 [ciliary membrane] (R-HSA-5632517)	0.499	2
UniProt:Q14674 ESPL1	4	ESPL1(1-1506) [cytosol] (R-HSA-2467768) ESPL1(1507-1535) [cytosol] (R-HSA-2500272) ESPL1(1536-2120) [cytosol] (R-HSA-2467767) ESPL1 [cytosol] (R-HSA-1638167)	0.462	2

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