Reactome | CCNA2 [nucleoplasm]

CCNA2 [nucleoplasm]

Stable Identifier

R-HSA-68905

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclin A2, Cyclin A

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        CDK2 phosphorylates RBBP8 (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)
        
        MRN complex binds CDK2 and RBBP8 (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:CCNA:p-T160-CDK2:RBBP8 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CDK2 phosphorylates TP53 (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 (Homo sapiens)
        
        CCNA:p-CDK1/2 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T160-CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)
        
        CCNA:p-T161-CDK1 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)
        
        CCNA:CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)
        
        Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] (Homo sapiens)
        
        CCNA:CDK2 [nucleoplasm] (Homo sapiens)
        
        CCNA [nucleoplasm] (Homo sapiens)
        
        CCNA2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P20248 CCNA2

Gene Names

CCNA2, CCN1, CCNA

Chain

chain:1-432

Reference Genes

BioGPS Gene:890 CCNA2

COSMIC (genes):CCNA2 CCNA2

CTD Gene:890 CCNA2

dbSNP Gene:890 CCNA2

ENSEMBL:ENSG00000145386 CCNA2

ENSEMBL_homo_sapiens_GENE:ENSG00000145386.11 CCNA2

HGNC:1578 CCNA2

KEGG Gene (Homo sapiens):890 CCNA2

Monarch:890 CCNA2

NCBI Gene:890 CCNA2

OMIM:123835 CCNA2

UCSC:P20248 CCNA2

Reference Transcript

RefSeq:NM_001237.4 CCNA2

Other Identifiers

11722571_at

11722572_at

16979515

1943_at

203418_PM_at

203418_at

213226_PM_at

213226_at

2784114

2784115

2784116

2784117

2784119

2784120

2784121

2784122

2784123

2784125

2784128

2784129

2784130

40697_at

8102643

890

A_23_P58321

GE59759

GO:0000082

GO:0000086

GO:0000278

GO:0000307

GO:0001939

GO:0001940

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006260

GO:0006275

GO:0006351

GO:0006355

GO:0007049

GO:0007265

GO:0016538

GO:0019901

GO:0019904

GO:0023052

GO:0031100

GO:0032355

GO:0033762

GO:0036120

GO:0036211

GO:0043226

GO:0043687

GO:0044320

GO:0044772

GO:0044843

GO:0045893

GO:0048146

GO:0048856

GO:0051301

GO:0071314

GO:0071373

GO:0071392

GO:0071407

GO:0071456

GO:0071732

GO:0090102

GO:0097122

GO:0097124

GO:0098772

GO:1990314

GO:2000573

HMNXSV003001266

Hs.91728.1.A1_3p_at

ILMN_1786125

PH_hs_0004815

TC04001516.hg

X51688_at

g4502612_3p_at

Participates

as a member of

CCNA1,CCNA2 [nucleoplasm] (Homo sapiens)

as a component of

CCNA2:p-T161-CDK1 [nucleoplasm] (Homo sapiens)

as an output of

CCNA2 gene expression is inhibited by RBL1 and RBL2 (Homo sapiens)

as a candidate of

CCNA [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PolyUb-CCNA2 [nucleoplasm]

CCNA2 [cytosol]

Inferred To

CCNA2 [nucleoplasm] (Bos taurus)

CCNA2 [nucleoplasm] (Canis familiaris)

CCNA2 [nucleoplasm] (Gallus gallus)

CCNA2 [nucleoplasm] (Sus scrofa)

ccna2 [nucleoplasm] (Danio rerio)

ccna2 [nucleoplasm] (Xenopus tropicalis)

Ccna2 [nucleoplasm] (Mus musculus)

Ccna2 [nucleoplasm] (Rattus norvegicus)

CycA [nucleoplasm] (Drosophila melanogaster)

crs1 [nucleoplasm] (Schizosaccharomyces pombe)

cya-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001228.1

OpenTargets

ENSG00000145386

GeneCards

P20248

HPA

ENSG00000145386-CCNA2

ZINC - Substances

CCNA2_HUMAN

Ensembl

ENST00000274026, ENSP00000274026, ENSG00000145386

ZINC target

P20248

PRO

P20248

Pharos - Targets

P20248

ZINC - Predictions - Purchasable

CCNA2_HUMAN

PDB

2WFY, 6ATH, 4EOP, 2UZL, 2WMA, 2UUE, 1H26, 1H28, 1GY3, 1FVV, 1H27, 1H1P, 1OIU, 7B7S, 2CCH, 1OGU, 2I40, 6Q6H, 1H1R, 4CFW, 7B5L, 1H1Q, 1H1S, 4EON, 2C4G, 4EOM, 6Q6G, 1JST, 2WPA, 1OKW, 4EOQ, 1OL1, 1JSU, 1OL2, 4EOO, 7QHL, 1P5E, 7MKX, 2CJM, 3EOC, 4CFN, 2BPM, 4CFM, 2IW6, 4BCN, 2C5O, 2WEV, 2V22, 2WIH, 2C5N, 1OKV, 7LUO, 1URC, 2WHB, 2CCI, 2WIP, 4BCP, 4EOR, 5LMK, 1PKD, 2UZD, 4FX3, 4EOJ, 4EOI, 3F5X, 4CFU, 2WMB, 5CYI, 2C6T, 2X1N, 1QMZ, 2WXV, 1VYW, 6SG4, 2C5V, 2UZB, 2C5X, 1E9H, 4CFV, 7B5R, 1OIY, 1OI9, 2UZE, 6GVA, 1H24, 8B54, 7ACK, 5IF1, 1H25, 4CFX, 2BKZ, 6P3W, 8BYA, 3EID, 4BCK, 4EOS, 6RIJ, 3EJ1, 5NEV, 4EOL, 8BZO, 4BCM, 4EOK, 2IW9, 2IW8, 1FIN

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.977	33
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.967	21
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.837	9
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.802	8
UniProt:Q9BY12 SCAPE			0.744	6
UniProt:Q13415 ORC1	5	ORC1 [nucleoplasm] (R-HSA-68522) ORC1 [cytosol] (R-HSA-113840) p-S,T-ORC1 [nucleoplasm] (R-HSA-68943) PolyUb,p-S,T-ORC1 [nucleoplasm] (R-HSA-9032189) PolyUb,p-S,T-ORC1 [cytosol] (R-HSA-9032195)	0.725	5
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.725	6
UniProt:Q99640 PKMYT1	3	PKMYT1 [cytosol] (R-HSA-157457) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [nucleoplasm] (R-HSA-74386)	0.725	6
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.725	6
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.725	7
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.69	7
UniProt:Q00526 CDK3			0.643	5
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.643	5
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.643	3
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.643	4
UniProt:Q9H147 TDIF1			0.643	4
UniProt:Q6PJG2 MDEAS			0.643	5
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.643	6
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.643	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	4
UniProt:P03129 VE7			0.564	2
UniProt:Q8NG08 HELB			0.527	3
UniProt:Q9Y3Z3 SAMHD1	1	SAMHD1 [nucleoplasm] (R-HSA-5624198)	0.527	2
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.527	3
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.527	2
UniProt:P49918-2 CDKN1C			0.527	2
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.527	4
UniProt:Q9Y463 DYR1B			0.527	2
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.527	3
UniProt:P09681 GIP	6	GIP(22-153) [endoplasmic reticulum lumen] (R-HSA-400512) GIP(22-153) [secretory granule lumen] (R-HSA-400526) GIP(52-93) [secretory granule lumen] (R-HSA-400483) GIP(54-93) [extracellular region] (R-HSA-400542) GIP(1-153) [endoplasmic reticulum lumen] (R-HSA-400470) GIP(52-93) [extracellular region] (R-HSA-400540)	0.527	2
UniProt:P33552 CKS2			0.527	4
UniProt:P19525 EIF2AK2	5	p-EIF2AK2 [nucleoplasm] (R-HSA-9836332) SUMO-EIF2AK2 [cytosol] (R-HSA-9834829) ISG15-EIF2AK2 [cytosol] (R-HSA-9833968) p-EIF2AK2 [cytosol] (R-HSA-9833834) EIF2AK2 [cytosol] (R-HSA-168699)	0.527	2
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.527	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.524	2

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