The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin

Stable Identifier
R-HSA-68913
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
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At the beginning of this reaction, 1 molecule of 'DNA polymerase alpha:primase:DNA polymerase alpha:origin complex', and 1 molecule of 'NTP' are present. At the end of this reaction, 1 molecule of 'DNA polymerase epsilon', and 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed RNA polymerase activity' of 'DNA polymerase alpha:primase'.
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Output
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Catalyst Activity

DNA-directed RNA polymerase activity of DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm]

Physical Entity
DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm] (Homo sapiens)
Activity
DNA-directed RNA polymerase activity (GO:0003899)
Orthologous Events
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Bos taurus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Caenorhabditis elegans)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Canis familiaris)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Danio rerio)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Dictyostelium discoideum)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Drosophila melanogaster)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Gallus gallus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Mus musculus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Plasmodium falciparum)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Rattus norvegicus)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Saccharomyces cerevisiae)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Schizosaccharomyces pombe)
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin (Sus scrofa)
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