The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin

Stable Identifier
R-HSA-68913
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the beginning of this reaction, 1 molecule of 'DNA polymerase alpha:primase:DNA polymerase alpha:origin complex', and 1 molecule of 'NTP' are present. At the end of this reaction, 1 molecule of 'DNA polymerase epsilon', and 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed RNA polymerase activity' of 'DNA polymerase alpha:primase'.

Literature References
Participants
Participates
Catalyst Activity

DNA-directed 5'-3' RNA polymerase activity of DNA polymerase alpha:primase:DNA polymerase alpha:origin complex [nucleoplasm]

Orthologous Events
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