Reactome | p-S,T-ORC1 [nucleoplasm]

p-S,T-ORC1 [nucleoplasm]

Stable Identifier

R-HSA-68943

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phosphorylated Orc1, Origin recognition complex subunit 1, Replication control protein 1

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External Reference Information

External Reference

UniProt:Q13415 ORC1

Gene Names

ORC1, ORC1L, PARC1

Chain

chain:1-861

Reference Genes

BioGPS Gene:4998 ORC1

COSMIC (genes):ORC1 ORC1

CTD Gene:4998 ORC1

dbSNP Gene:4998 ORC1

ENSEMBL:ENSG00000085840 ORC1

HGNC:8487 ORC1

KEGG:hsa:4998 ORC1

Monarch:4998 ORC1

NCBI Gene:4998 ORC1

OMIM:601902 ORC1

UCSC:Q13415 ORC1

Reference Transcript

Other Identifiers

11727839_x_at

16687188

205085_PM_at

205085_at

2412800

2412801

2412802

2412803

2412804

2412805

2412807

2412809

2412810

2412811

2412812

2412813

2412814

2412815

2412818

2412819

2412820

2412822

2412823

2412824

2412825

2412826

2412827

2412829

2412830

2412831

2412833

38564_at

4998

7916167

A_23_P45799

GE59132

GO:0000781

GO:0000808

GO:0003677

GO:0003682

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005664

GO:0005829

GO:0006260

GO:0006270

GO:0016787

GO:0016887

GO:0033314

GO:0043226

GO:0046872

HMNXSV003053435

ILMN_1727459

PH_hs_0001609

TC01002658.hg

U40152_s_at

g4758849_3p_at

g4758849_3p_x_at

Participates

as an input of

Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)

as an output of

Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)

Other forms of this molecule

ORC1 [nucleoplasm]

ORC1 [cytosol]

PolyUb,p-S,T-ORC1 [nucleoplasm]

PolyUb,p-S,T-ORC1 [cytosol]

Inferred To

phospho-orc1 [nucleoplasm] (Xenopus tropicalis)

phospho-p-S,T-ORC1 [nucleoplasm] (Dictyostelium discoideum)

phospho-p-S,T-ORC1 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S,T-ORC1 [nucleoplasm] (Gallus gallus)

phospho-p-S,T-ORC1 [nucleoplasm] (Mus musculus)

phospho-p-S,T-ORC1 [nucleoplasm] (Plasmodium falciparum)

phospho-p-S,T-ORC1 [nucleoplasm] (Rattus norvegicus)

phospho-p-S,T-ORC1 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-p-S,T-ORC1 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-orc-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-ORC1 [nucleoplasm] (Bos taurus)

phospho-ORC1 [nucleoplasm] (Canis familiaris)

phospho-ORC1 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_004144.2, NP_001177747.1, NP_001177748.1

OpenTargets

ENSG00000085840

ENSEMBL

ENST00000371566, ENST00000371568, ENSP00000360623, ENSP00000360621

HPA

ENSG00000085840-ORC1

PRO

Q13415

Pharos - Targets

Q13415

Orphanet

ORC1

GlyGen

Q13415

PDB

7JPS, 7JPR, 5UJ7, 7JPP, 5UJM, 7JPO, 6P3W, 7CTG, 7CTF

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13416 ORC2	1	ORC2 [nucleoplasm] (R-HSA-68405)	0.888	14
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.868	11
UniProt:Q9UBD5 ORC3	1	ORC3 [nucleoplasm] (R-HSA-68513)	0.824	16
UniProt:O43929 ORC4	1	ORC4 [nucleoplasm] (R-HSA-68519)	0.737	8
UniProt:P20248 CCNA2	3	CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.725	5
IntAct:EBI-15973242 H4(1129)			0.618	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q15554 TERF2	2	p-S365-TERF2 [nucleoplasm] (R-HSA-9686530) TERF2 [nucleoplasm] (R-HSA-174895)	0.544	2
UniProt:P03211 EBNA1			0.544	2
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.524	2

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